Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study

{ 'indexed': {'date-parts': [[2023, 5, 12]], 'date-time': '2023-05-12T04:38:50Z', 'timestamp': 1683866330491}, 'reference-count': 30, 'publisher': 'MDPI AG', 'issue': '5', 'license': [ { 'start': { 'date-parts': [[2023, 5, 10]], 'date-time': '2023-05-10T00:00:00Z', 'timestamp': 1683676800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [{'name': 'Consellería de Sanitat Universal i Salut Pública', 'award': ['UGP-21-410']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Introduction. There is negligible evidence on the efficacy of ivermectin for treating ' 'COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively ' 'treating Strongyloides stercoralis hyperinfection syndrome in order to reduce mortality and ' 'the need for respiratory support in patients hospitalized for COVID-19. Methods. This ' 'single-center, observational, retrospective study included patients admitted with COVID-19 ' 'pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because ' 'strongyloidiasis is endemic to our area, medical criteria support empiric administration of a ' 'single, 200 μg/kg dose of ivermectin to prevent Strongyloides hyperinfection syndrome. The ' 'outcome was a composite of all-cause in-hospital mortality and the need for respiratory ' 'support. Results. Of 1167 patients in the cohort, 96 received ivermectin. After propensity ' 'score matching, we included 192 patients. The composite outcome of in-hospital mortality or ' 'need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) ' 'of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted ' 'odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69; p = 0.52). The factors ' 'independently associated with this endpoint were oxygen saturation (aOR 0.78, 95% CI 0.68, ' '0.89, p &lt; 0.001) and C-reactive protein at admission (aOR: 1.09, 95% CI 1.03, 1.16, p &lt; ' '0.001). Conclusions. In hospitalized patients with COVID-19 pneumonia, ivermectin at a single ' 'dose for pre-emptively treating Strongyloides stercoralis is not effective in reducing ' 'mortality or the need for respiratory support measures.</jats:p>', 'DOI': '10.3390/v15051138', 'type': 'journal-article', 'created': {'date-parts': [[2023, 5, 11]], 'date-time': '2023-05-11T05:37:09Z', 'timestamp': 1683783429000}, 'page': '1138', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 ' 'Pneumonia: Propensity Score-Matched Retrospective Study', 'prefix': '10.3390', 'volume': '15', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-9125-7706', 'authenticated-orcid': False, 'given': 'Jara', 'family': 'Llenas-García', 'sequence': 'first', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}, { 'name': 'Clinical Medicine Department, Miguel Hernández University, 03202 ' 'Elche, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6991-923X', 'authenticated-orcid': False, 'given': 'Alfonso', 'family': 'del Pozo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5594-8083', 'authenticated-orcid': False, 'given': 'Alberto', 'family': 'Talaya', 'sequence': 'additional', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}]}, { 'given': 'Nuria', 'family': 'Roig-Sánchez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6217-6077', 'authenticated-orcid': False, 'given': 'Noemí', 'family': 'Poveda Ruiz', 'sequence': 'additional', 'affiliation': [ { 'name': 'Infectious Diseases Unit, Hospital Reina Sofía, 30003 Murcia, ' 'Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-8350-5124', 'authenticated-orcid': False, 'given': 'Carlos', 'family': 'Devesa García', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hospital Pharmacy Department, Hospital Vega Baja, 03314 ' 'Orihuela, Spain'}]}, { 'given': 'Emilio', 'family': 'Borrajo Brunete', 'sequence': 'additional', 'affiliation': [ { 'name': 'Microbiology Department, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-8519-7823', 'authenticated-orcid': False, 'given': 'Inmaculada', 'family': 'González Cuello', 'sequence': 'additional', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}]}, { 'given': 'Ana', 'family': 'Lucas Dato', 'sequence': 'additional', 'affiliation': [ { 'name': 'Internal Medicine Service, Hospital Vega Baja, 03314 Orihuela, ' 'Spain'}, { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0001-7727-1587', 'authenticated-orcid': False, 'given': 'Miriam', 'family': 'Navarro', 'sequence': 'additional', 'affiliation': [ { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}, {'name': 'Epidemiology Unit, Public Health Centre, 03202 Elche, Spain'}]}, { 'given': 'Philip', 'family': 'Wikman-Jorgensen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Foundation for the Promotion of Health and Biomedical Research ' 'of the Valencia Region (FISABIO), 46020 Valencia, Spain'}, { 'name': 'Internal Medicine Service, Elda General University Hospital, ' '03600 Elda, Spain'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 5, 10]]}, 'reference': [ { 'key': 'ref_1', 'unstructured': 'WHO Coronavirus (COVID-19) Dashboard (2022, November 02). 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Health'}], 'container-title': 'Viruses', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/1999-4915/15/5/1138/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 5, 11]], 'date-time': '2023-05-11T05:39:51Z', 'timestamp': 1683783591000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/1999-4915/15/5/1138'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 5, 10]]}, 'references-count': 30, 'journal-issue': {'issue': '5', 'published-online': {'date-parts': [[2023, 5]]}}, 'alternative-id': ['v15051138'], 'URL': 'http://dx.doi.org/10.3390/v15051138', 'relation': {}, 'ISSN': ['1999-4915'], 'subject': ['Virology', 'Infectious Diseases'], 'container-title-short': 'Viruses', 'published': {'date-parts': [[2023, 5, 10]]}}