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0 0.5 1 1.5 2+ Mortality 17% Improvement Relative Risk Oxygen therapy 18% Progression 23% primary ICU admission -4% Ivermectin  Llenas-García et al.  LATE TREATMENT Is late treatment with ivermectin beneficial for COVID-19? Retrospective 192 patients in Spain (February 2020 - March 2021) Lower need for oxygen therapy (p=0.37) and lower progression (p=0.52), not sig. c19ivm.org Llenas-García et al., Viruses, May 2023 Favors ivermectin Favors control

Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study

Llenas-García et al., Viruses, doi:10.3390/v15051138
May 2023  
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Retrospective 96 late stage patients receiving a single dose of 200 μg/kg ivermectin for strongyloides and 96 matched controls, showing no significant difference in outcomes. Authors note that this may be due to the low dose used.
This is the 97th of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion). 46 studies are RCTs, which show efficacy with p=0.00000014.
risk of death, 16.7% lower, RR 0.83, p = 0.82, treatment 10 of 96 (10.4%), control 12 of 96 (12.5%), NNT 48.
risk of oxygen therapy, 18.4% lower, RR 0.82, p = 0.37, treatment 31 of 96 (32.3%), control 38 of 96 (39.6%), NNT 14.
risk of progression, 23.0% lower, OR 0.77, p = 0.52, treatment 96, control 96, adjusted per study, in-hospital mortality or respiratory support, multivariable, primary outcome, RR approximated with OR.
risk of ICU admission, 4.0% higher, OR 1.04, p = 0.92, treatment 96, control 96, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Llenas-García et al., 10 May 2023, retrospective, Spain, peer-reviewed, 11 authors, study period 23 February, 2020 - 14 March, 2021, average treatment delay 6.0 days, dosage 200μg/kg single dose.
Contact: jllenas@umh.es (corresponding author), alfonsodelpozo@gmail.com, igcuello@hotmail.com.
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Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study
Jara Llenas-García, Alfonso Del Pozo, Alberto Talaya, Nuria Roig-Sánchez, Noemí Poveda Ruiz, Carlos Devesa García, Emilio Borrajo Brunete, Inmaculada González Cuello, Ana Lucas Dato, Miriam Navarro, Philip Wikman-Jorgensen
Viruses, doi:10.3390/v15051138
Introduction. There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating Strongyloides stercoralis hyperinfection syndrome in order to reduce mortality and the need for respiratory support in patients hospitalized for COVID-19. Methods. This single-center, observational, retrospective study included patients admitted with COVID-19 pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because strongyloidiasis is endemic to our area, medical criteria support empiric administration of a single, 200 µg/kg dose of ivermectin to prevent Strongyloides hyperinfection syndrome. The outcome was a composite of all-cause in-hospital mortality and the need for respiratory support. Results. Of 1167 patients in the cohort, 96 received ivermectin. After propensity score matching, we included 192 patients. The composite outcome of in-hospital mortality or need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69; p = 0.52). The factors independently associated with this endpoint were oxygen saturation (aOR 0.78, 95% CI 0.68, 0.89, p < 0.001) and C-reactive protein at admission (aOR: 1.09, 95% CI 1.03, 1.16, p < 0.001). Conclusions. In hospitalized patients with COVID-19 pneumonia, ivermectin at a single dose for pre-emptively treating Strongyloides stercoralis is not effective in reducing mortality or the need for respiratory support measures.
Conflicts of Interest: The authors declare no conflict of interest.
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Late treatment
is less effective
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