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All Studies   Meta Analysis    Recent:   

Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study

Llenas-García et al., Viruses, doi:10.3390/v15051138
May 2023  
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Mortality 17% Improvement Relative Risk Oxygen therapy 18% Progression 23% primary ICU admission -4% Ivermectin  Llenas-García et al.  LATE TREATMENT Is late treatment with ivermectin beneficial for COVID-19? Retrospective 192 patients in Spain (February 2020 - March 2021) Lower need for oxygen therapy (p=0.37) and lower progression (p=0.52), not sig. c19ivm.org Llenas-García et al., Viruses, May 2023 Favorsivermectin Favorscontrol 0 0.5 1 1.5 2+
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 95 treatments. c19ivm.org
Retrospective 96 late stage patients receiving a single dose of 200 μg/kg ivermectin for strongyloides and 96 matched controls, showing no significant difference in outcomes. Authors note that this may be due to the low dose used.
This is the 98th of 105 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 774 quintillion).
52 studies are RCTs, which show efficacy with p=0.00000021.
risk of death, 16.7% lower, RR 0.83, p = 0.82, treatment 10 of 96 (10.4%), control 12 of 96 (12.5%), NNT 48.
risk of oxygen therapy, 18.4% lower, RR 0.82, p = 0.37, treatment 31 of 96 (32.3%), control 38 of 96 (39.6%), NNT 14.
risk of progression, 23.0% lower, OR 0.77, p = 0.52, treatment 96, control 96, adjusted per study, in-hospital mortality or respiratory support, multivariable, primary outcome, RR approximated with OR.
risk of ICU admission, 4.0% higher, OR 1.04, p = 0.92, treatment 96, control 96, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Llenas-García et al., 10 May 2023, retrospective, Spain, peer-reviewed, 11 authors, study period 23 February, 2020 - 14 March, 2021, average treatment delay 6.0 days, dosage 200μg/kg single dose. Contact: jllenas@umh.es (corresponding author), alfonsodelpozo@gmail.com, igcuello@hotmail.com.
This PaperIvermectinAll
Ivermectin Effect on In-Hospital Mortality and Need for Respiratory Support in COVID-19 Pneumonia: Propensity Score-Matched Retrospective Study
Jara Llenas-García, Alfonso Del Pozo, Alberto Talaya, Nuria Roig-Sánchez, Noemí Poveda Ruiz, Carlos Devesa García, Emilio Borrajo Brunete, Inmaculada González Cuello, Ana Lucas Dato, Miriam Navarro, Philip Wikman-Jorgensen
Viruses, doi:10.3390/v15051138
Introduction. There is negligible evidence on the efficacy of ivermectin for treating COVID-19 pneumonia. This study aimed to assess the efficacy of ivermectin for pre-emptively treating Strongyloides stercoralis hyperinfection syndrome in order to reduce mortality and the need for respiratory support in patients hospitalized for COVID-19. Methods. This single-center, observational, retrospective study included patients admitted with COVID-19 pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because strongyloidiasis is endemic to our area, medical criteria support empiric administration of a single, 200 µg/kg dose of ivermectin to prevent Strongyloides hyperinfection syndrome. The outcome was a composite of all-cause in-hospital mortality and the need for respiratory support. Results. Of 1167 patients in the cohort, 96 received ivermectin. After propensity score matching, we included 192 patients. The composite outcome of in-hospital mortality or need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69; p = 0.52). The factors independently associated with this endpoint were oxygen saturation (aOR 0.78, 95% CI 0.68, 0.89, p < 0.001) and C-reactive protein at admission (aOR: 1.09, 95% CI 1.03, 1.16, p < 0.001). Conclusions. In hospitalized patients with COVID-19 pneumonia, ivermectin at a single dose for pre-emptively treating Strongyloides stercoralis is not effective in reducing mortality or the need for respiratory support measures.
Conflicts of Interest: The authors declare no conflict of interest.
References
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This ' 'single-center, observational, retrospective study included patients admitted with COVID-19 ' 'pneumonia at Hospital Vega Baja from 23 February 2020 to 14 March 2021. Because ' 'strongyloidiasis is endemic to our area, medical criteria support empiric administration of a ' 'single, 200 μg/kg dose of ivermectin to prevent Strongyloides hyperinfection syndrome. The ' 'outcome was a composite of all-cause in-hospital mortality and the need for respiratory ' 'support. Results. Of 1167 patients in the cohort, 96 received ivermectin. After propensity ' 'score matching, we included 192 patients. The composite outcome of in-hospital mortality or ' 'need for respiratory support occurred in 41.7% of the control group (40/96) and 34.4% (33/96) ' 'of the ivermectin group. Ivermectin was not associated with the outcome of interest (adjusted ' 'odds ratio [aOR] 0.77, 95% confidence interval [CI] 0.35, 1.69; p = 0.52). The factors ' 'independently associated with this endpoint were oxygen saturation (aOR 0.78, 95% CI 0.68, ' '0.89, p &lt; 0.001) and C-reactive protein at admission (aOR: 1.09, 95% CI 1.03, 1.16, p &lt; ' '0.001). Conclusions. 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Health'}, { 'key': 'ref_29', 'doi-asserted-by': 'crossref', 'first-page': '623', 'DOI': '10.1001/jama.2020.13170', 'article-title': 'COVID-19 and Dexamethasone: A Potential Strategy to Avoid ' 'Steroid-Related Strongyloides Hyperinfection', 'volume': '324', 'author': 'Stauffer', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': 'ref_30', 'doi-asserted-by': 'crossref', 'first-page': 'e002321', 'DOI': '10.1136/bmjgh-2020-002321', 'article-title': 'Cost-Effectiveness of Different Strategies for Screening and Treatment ' 'of Strongyloides Stercoralis in Migrants from Endemic Countries to the ' 'European Union', 'volume': '5', 'author': 'Shedrawy', 'year': '2020', 'journal-title': 'BMJ Glob. Health'}], 'container-title': 'Viruses', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/1999-4915/15/5/1138/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 5, 11]], 'date-time': '2023-05-11T05:39:51Z', 'timestamp': 1683783591000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/1999-4915/15/5/1138'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 5, 10]]}, 'references-count': 30, 'journal-issue': {'issue': '5', 'published-online': {'date-parts': [[2023, 5]]}}, 'alternative-id': ['v15051138'], 'URL': 'http://dx.doi.org/10.3390/v15051138', 'relation': {}, 'ISSN': ['1999-4915'], 'subject': ['Virology', 'Infectious Diseases'], 'container-title-short': 'Viruses', 'published': {'date-parts': [[2023, 5, 10]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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