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Clinical Experience With Ivermectin and Nitazoxanide in the Management of COVID-19 Among Mexican Out- and Inpatients

García-Méndez et al., Cureus, doi:10.7759/cureus.74513, Nov 2024
https://c19ivm.org/garciamendez.html
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 24 countries.
No treatment is 100% effective. Protocols combine treatments.
5,900+ studies for 173 treatments. c19ivm.org
Prospective study of 228 outpatients and 179 inpatients in Mexico showing potential benefits with ivermectin and nitazoxanide treatment for COVID-19. Ivermectin improved viral clearance compared to nitazoxanide, and the combination of both was more effective with early treatment. Mortality and mechanical ventilation were lower than expected rates. There was no control group.
Study covers ivermectin and nitazoxanide.
García-Méndez et al., 26 Nov 2024, retrospective, Mexico, peer-reviewed, mean age 52.2, 10 authors, study period September 2020 - November 2021. Contact: habarrera@gmail.com.
Clinical Experience With Ivermectin and Nitazoxanide in the Management of COVID-19 Among Mexican Out- and Inpatients
Jorge O García-Méndez, Luis E Fernández-Garza, Karen Vallejo-Oviedo, Diana I Gómez-Curiel, Silvia A Barrera-Barrera, Rosario Ordaz-Cuellar, Jesús O Sosa-García, Rogelio A García-Torrentera, Eduardo Cervera, Hugo A Barrera-Saldaña
Cureus, doi:10.7759/cureus.74513
Background and objective The use of ivermectin and nitazoxanide in the treatment of coronavirus disease 2019 (COVID-19) has been a subject of controversy. In this study, we aimed to describe our clinical experience in treating COVID-19 patients with these drugs in Mexico. Material and methods The study involved out-and inpatient clinical assessments of COVID-19 patients conducted in Mexico City from September 2020 to November 2021. Outpatients were treated with either ivermectin, nitazoxanide, or both drugs, while all inpatients received both. Clinical and laboratory analyses were used to assess the results. Results Of the 228 subjects in the outpatient group, 26.8% received ivermectin, 25.4% nitazoxanide, and 47.8% both. The proportion of negative polymerase chain reaction (PCR) was highest in patients treated late with ivermectin (≥5 days after symptom onset; p=0.004), followed by those receiving late treatment with nitazoxanide, and those with the combination at any time. The inpatient group had 179 subjects. A significant increase was seen in neutrophil, lymphocyte, monocyte, ferritin, and D-dimer levels, while an opposite trend was observed for C-reactive protein (CRP) and fibrinogen levels. Mechanical ventilation requirement was 15.5%, and 5% died during hospitalization. Conclusions Despite the limitations of our study, based on its findings, ivermectin and nitazoxanide could be useful in reducing the viral load, the requirement for mechanical ventilation, proinflammatory and procoagulant parameters, and the fatality rate in COVID-19 patients. Controlled clinical trials evaluating this combination should be carried out to determine its true usefulness and safety profile.
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Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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