Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours
Stone et al.
, Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62%..
, Biologics, doi:10.3390/biologics2030015 (date from earlier preprint)
Retrospective severe COVID-19 patients in Zimbabwe treated with ivermectin, doxycycline, and zinc. For 34 with SpO2
tracking, there was rapid improvement in SpO2
, with 55% recovery towards SpO2
=97 within 12 hours. The preprint shows further analysis of all 92 severe cases: there were 2 deaths and 2 additional progressions prior to recovery, significantly less than a predicted 7 deaths and 17 deteriorations based on demographics and risk factors [researchsquare.com]
Stone et al., 9 Nov 2021, retrospective, South Africa, peer-reviewed, mean age 55.0, 7 authors, study period August 2020 - May 2021.
email@example.com (corresponding author).
Abstract: Rapid increase of SpO2 on room air for 34 severe
COVID-19 patients after ivermectin-based combination
treatment: 55-62% normalization within 12-24 hours
Jacqueline C Stone
College of Primary Care Physicians of Zimbabwe, Harare, Zimbabwe
National Coordinator Ivermectin Research (MoHCC), Harare, Zimbabwe
David E Scheim ( firstname.lastname@example.org )
US Public Health Service, Commissioned Corps, Inactive Reserve, Blacksburg, VA, US
Barry M Dancis
Independent bioinformatics consultant, Silver Spring, MD, US
Department of Mathematics, University of Maryland, College Park, MD, US
Martin G Gill
ENT Surgeon, Private Practice, Fourways Life Hospital, Gauteng, South Africa
College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa https://orcid.org/0000-00027199-9160
Keywords: COVID-19, SARS-CoV-2, spike protein, ivermectin, doxycycline, SpO2
Posted Date: November 9th, 2021
License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read
Background. The emergence of COVID-19 in March 2020 challenged Zimbabwe to mount a response with
limited medical facilities and therapeutic options. Ivermectin (IVM) had by then been safely used to treat a
variety of human diseases affecting millions, as noted by the Nobel Committee in awarding its 2015 prize for
medicine. Based upon early clinical indications of efficacy against COVID-19, IVM-based combination
treatments were deployed to treat this infection in Zimbabwe.
Methods. Data were retrospectively analyzed for 34 severe COVID-19 patients treated with IVM-based
combination therapy between August 2020 and May 2021, for whom pre- and post-treatment SpO2 values
were all recorded on room air. Mortality and deterioration outcomes were also analyzed for a larger set of 92
severe COVID-19 patients receiving IVM-based treatment.
Results: For the 34-patient SpO2 tracking series, all but two patients had significantly increased SpO2 values
after the first IVM dose, and all patients recovered. Mean increases in SpO2 as percentages of full
normalization to SpO2=97 were 55.1% at +12 hours and 62.3% at +24 hours post-treatment. These results
paralleled similar sharp increases in SpO2, all on room air, for a series of 24 RT-qPCR confirmed, mostly severe
COVID-19 patients in the USA (California) who were given IVM combination treatment, all of whom recovered.
For 19 of those patients having SpO2 ≤ 90 prior to IVM, the mean SpO2 normalization at +24 hours posttreatment was 65.2% as calculated from the SpO2 values reported. For our larger series of 92 severe COVID-19
patients in Zimbabwe, median age 53, only two died and two more deteriorated prior to recovery, far less than
a predicted 7 deaths and 17 deteriorations for the demographics and risk factors of these patients.
Conclusions. The rapid, marked increases in SpO2 for both the Zimbabwe and California patients stand in
sharp contrast to the decline in SpO2 and associated pulmonary function following onset of moderate or
severe COVID-19 symptoms under standard care. These rapid SpO2 increases and low mortality rates support
extended deployment of IVM treatment for COVID-19, complementary to immunizations for prevention.
Evaluations of efficacy for COVID-19 therapeutics are challenging since most patients with this..
is less effective
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