Association between Ivermectin treatment and mortality in Covid-19: A hospital-based case-control study

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2022, 4, 6]], 'date-time': '2022-04-06T16:12:44Z', 'timestamp': 1649261564193}, 'posted': {'date-parts': [[2022, 4, 6]]}, 'group-title': 'In Review', 'reference-count': 0, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2022, 4, 6]], 'date-time': '2022-04-06T00:00:00Z', 'timestamp': 1649203200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': [], 'accepted': {'date-parts': [[2022, 4, 4]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>Introduction\n' ' : This study was designed to test the hypothesis that exposure to ivermectin in early ' 'disease prevents mortality due to COVID-19. A secondary objective was to see if the drug has ' 'any impact on the length of hospital stay among the survivors.\n' 'Methods\n' ' It was a hospital-based retrospective case control Study conducted at a tertiary teaching ' 'hospital in India. All patients with a diagnosis of COVID-19 who were admitted between 1st ' 'April and 15th May 2021 and received inpatient care were included. Important variables like ' 'demographic details, dates of admission and discharge or death, symptoms at the time of ' 'admission, comorbidities, severity of illness at the time of admission, whether ivermectin ' 'was administered or not during the course of the illness and other treatments received as ' 'part of the standard of care were retrieved from the medical records.\n' 'Results\n' ' Of the 965 patients who received inpatient care, 307 died during their hospital stay while ' '658 were successfully discharged. The proportion of cases treated with ivermectin was 17.26% ' 'among the non-survivors (53/307) and 17.93% among the survivors (118/658). The effect was ' 'statistically insignificant (crude OR\u2009=\u20090.954 ;95% CI: 0.668–1.364, p\u2009=\u2009' '0.80). Among the survivors, the median length of stay was 11 days for patients who received ' 'ivermectin (IQR: 7–15) as well as for those who did not (IQR 7–16).\n' 'Conclusion\n' ' This study did not show any effect of ivermectin on in-patient mortality in patients with ' 'COVID-19 and there was no effect of the drug on the length of hospital stay among the ' 'survivors.</jats:p>', 'DOI': '10.21203/rs.3.rs-1522422/v1', 'type': 'posted-content', 'created': {'date-parts': [[2022, 4, 6]], 'date-time': '2022-04-06T15:29:04Z', 'timestamp': 1649258944000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Association between Ivermectin treatment and mortality in Covid-19: A hospital-based ' 'case-control study'], 'prefix': '10.21203', 'author': [ { 'family': 'Ravikirti', 'sequence': 'first', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'given': 'Alok', 'family': 'Ranjan', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'given': 'Rajdeep', 'family': 'Porel', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'given': 'Ketan', 'family': 'Agarwal', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'given': 'SM', 'family': 'Tahaseen', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'family': 'Shyama', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}, { 'given': 'Anjani', 'family': 'Kumar', 'sequence': 'additional', 'affiliation': [{'name': 'All India Institute of Medical Sciences Patna'}]}], 'member': '8761', 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://www.researchsquare.com/article/rs-1522422/v1', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.researchsquare.com/article/rs-1522422/v1.html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 4, 6]], 'date-time': '2022-04-06T15:29:06Z', 'timestamp': 1649258946000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.researchsquare.com/article/rs-1522422/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 4, 6]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.21203/rs.3.rs-1522422/v1', 'relation': {}, 'published': {'date-parts': [[2022, 4, 6]]}, 'subtype': 'preprint'}