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A Meta-analysis of Mortality, Need for ICU admission, Use of Mechanical Ventilation and Adverse Effects with Ivermectin Use in COVID-19 Patients

Karale et al., medRxiv, doi:10.1101/2021.04.30.21256415
May 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Systematic review and meta analysis with 30 studies included in quantitative analysis, showing mortality OR 0.39 [0.22-0.70]. Subgroup analysis of trials with severity data showed mortality OR 0.10 [0.03-0.33] for mild/moderate cases.
7 meta analyses show significant improvements with ivermectin for mortality Bryant, Hariyanto, Kory, Lawrie, Nardelli, Zein, hospitalization Schwartz, recovery Kory, and cases Kory.
Currently there are 100 ivermectin for COVID-19 studies, showing 49% lower mortality [35‑60%], 29% lower ventilation [13‑42%], 38% lower ICU admission [14‑56%], 34% lower hospitalization [20‑45%], and 81% fewer cases [71‑87%].
Karale et al., 4 May 2021, preprint, 12 authors.
This PaperIvermectinAll
An Updated Systematic Review and Meta-Analysis of Mortality, Need for ICU admission, Use of Mechanical Ventilation, Adverse effects and other Clinical Outcomes of Ivermectin Treatment in COVID-19 Patients
MBBS Smruti Karale, MBBS, MPH Vikas Bansal, MBBS Janaki Makadia, Muhammad Tayyeb, Hira Khan, Shree Spandana Ghanta, MBBS Romil Singh, MD Aysun Tekin, Abhishek Bhurwal, MD Hemant Mutneja, MBB Ishita Mehra, MBBS, MBA Rahul Kashyap
Highlights What We Already Know about This Topic 1. COVID-19 is an ongoing global pandemic, for which Ivermectin has been tried on a therapeutic and prophylactic basis. 2. Results from several clinical trials and observational studies suggest that Ivermectin may improve survival and clinical outcomes with a good safety profile when compared with other treatments; however, the current evidence is limited. . What This Article Tells Us That Is New 1. This systematic review and meta-analysis provide a summary of the latest literature on the efficacy and safety of Ivermectin use for COVID-19. 2. Based on our analysis of the latest evidence, we found that Ivermectin's benefit in reducing mortality cannot be concluded with confidence . However, as an adjuvant
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