A Meta-analysis of Mortality, Need for ICU admission, Use of Mechanical Ventilation and Adverse Effects with Ivermectin Use in COVID-19 Patients
Karale et al.,
A Meta-analysis of Mortality, Need for ICU admission, Use of Mechanical Ventilation and Adverse Effects with..,
medRxiv, doi:10.1101/2021.04.30.21256415 (Preprint) (meta analysis)
Systematic review and meta analysis with 30 studies included in quantitative analysis, showing mortality OR 0.39 [0.22-0.70]. Subgroup analysis of trials with severity data showed mortality OR 0.10 [0.03-0.33] for mild/moderate cases.
Currently there are
95 ivermectin studies and meta analysis shows:
Karale et al., 4 May 2021, preprint, 12 authors.
Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.04.30.21256415; this version posted September 17, 2021. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
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An Updated Systematic Review and Meta-Analysis of Mortality, Need for ICU admission,
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Use of Mechanical Ventilation, Adverse effects and other Clinical Outcomes of Ivermectin
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Treatment in COVID-19 Patients
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*Smruti Karale, MBBS1; *Vikas Bansal, MBBS, MPH2; Janaki Makadia, MBBS3; Muhammad
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Tayyeb, MD4; Hira Khan, MBBS5; Shree Spandana Ghanta, MBBS6; Romil Singh, MBBS7;
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Aysun Tekin, MD8; Abhishek Bhurwal, M98; Hemant Mutneja, MD10; Ishita Mehra, MBB11;
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Rahul Kashyap, MBBS, MBA8
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1
Medical Graduate, Government Medical College Kolhapur, Kolhapur, India
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Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, MN, USA
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Medical Graduate, GMERS Medical College, Vadodara, Gujarat, India
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Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ, USA
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Department of Neurology, Allegheny General Hospital, Pittsburgh, PA, USA
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Department of Internal Medicine, St. Elizabeth's Medical Center, Boston, MA, USA
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Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, PA
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Department of Anesthesiology and Perioperative Medicine, Mayo Clinic Rochester, MN, USA
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Department of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson School of
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Medicine, New Brunswick, NJ, USA
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Division of Gastroenterology, Cook County Hospital, Chicago, Illinois
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Department of Internal Medicine, North Alabama Medical Center, Florence, AL, USA
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NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
medRxiv preprint doi: https://doi.org/10.1101/2021.04.30.21256415; this version posted September 17, 2021. The copyright holder for this
preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
It is made available under a CC-BY-NC-ND 4.0 International license .
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Corresponding Author:
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Vikas Bansal, MBBS, MPH
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Assistant Professor of Medicine
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Division of Pulmonary and Critical Care Medicine
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Mayo Clinic, Rochester, MN- 55905
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Email: bansal.vikas@mayo.edu
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Phone: +1-507-398-1595
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Word count: Abstract: 250; Manuscript: 5041
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Tables: 0 main, 8 supplemental
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Figures: 6 main, 31 supplemental
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Conflicts of Interest: None of the authors have reported any conflicts of interest.
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Financial Support: There is no financial disclosure related to this study.
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Author Contribution: *Authors 1(SK) and 2(VB) contributed equally in defining the study
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outline and manuscript writing. Data review and collection were done by HK, JM, SG, RS, SK,
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and MT; statistical analysis done by SK, VB, and AB. Quality assessment of studies was done by
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AT,JM, HK, MT, SK, VB and GRADE quality rating was done by AB, HM and VB. Study
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design, distribution of articles for critical review done by SK, VB and RK. Final approval was
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received from all authors. SK and VB is the guarantor of the paper, taking responsibility for the
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integrity of the work as a whole, from inception to..
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