Did Use Of Ivermectin In Latin America Sabotage Clinical Trials and Confuse The World Of Medicine?

Marinos, A., Do Your Own Research, Sep 2022

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Ivermectin for COVID-19

4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 24 countries.

Lower risk for mortality, ventilation, ICU, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,700+ studies for 135 treatments. c19ivm.org

Meta analysis of ivermectin trials showing community use of ivermectin in Latin America associated with lower observed efficacy in trials, consistent with the side effect profiles, Google Trends analysis, and investigator statements.

Author uses the same trials as1, finding a much stronger association than with strongyloides (which does not match the extended data set2 or expectations for the effect of strongyloides on the trial results3).

7 meta analyses show significant improvements with ivermectin for mortality4-9, hospitalization10, recovery6, and cases6.

Currently there are 105 ivermectin for COVID-19 studies, showing 47% lower mortality [34‑58%], 35% lower ventilation [17‑50%], 40% lower ICU admission [12‑58%], 34% lower hospitalization [21‑44%], and 81% fewer cases [71‑87%].

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1. Bitterman et al., Comparison of Trials Using Ivermectin for COVID-19 Between Regions With High and Low Prevalence of Strongyloidiasis, JAMA Network Open, doi:10.1001/jamanetworkopen.2022.3079.jamanetwork.com, doi.org.

2. c19ivm.org, c19ivm.org/meta.html#strongyloides.c19ivm.org/meta.html#strongyloides.

3. doyourownresearch.substack.com, doyourownresearch.substack.com/p/do-strongyloides-worms-explain-positive.doyourownresearch.substack.com/p/do-strongyloides-worms-explain-positive.

4. Bryant et al., Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001402.lww.com, doi.org.

5. Hariyanto et al., Ivermectin and outcomes from Covid-19 pneumonia: A systematic review and meta-analysis of randomized clinical trial studies, Reviews In Medical Virology, doi:10.1002/rmv.2265.wiley.com, doi.org.

6. Kory et al., Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19, American Journal of Therapeutics, doi:10.1097/MJT.0000000000001377.lww.com, doi.org.

7. Lawrie et al., Ivermectin reduces the risk of death from COVID-19 – a rapid review and meta-analysis in support of the recommendation of the Front Line COVID-19 Critical Care Alliance, Preprint, b3d2650e-e929-4448-a527-4eeb59304c7f.filesusr.com/ugd/593c4f_8cb655bd21b1448ba6cf1f4c59f0d73d.pdf.filesusr.com.

8. Nardelli et al., Crying wolf in time of Corona: the strange case of ivermectin and hydroxychloroquine. Is the fear of failure withholding potential life-saving treatment from clinical use?, Signa Vitae, doi:10.22514/sv.2021.043.signavitae.com, doi.org.

9. Zein et al., Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2021.102186.sciencedirect.com, doi.org.

10. Schwartz, E., Does ivermectin have a place in the treatment of mild Covid-19?, New Microbes and New Infections, doi:10.1016/j.nmni.2022.100989.sciencedirect.com, doi.org.

Marinos et al., 27 Sep 2022, preprint, 1 author.

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