Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lactoferrin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All ivermectin studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19ivm.org COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Azvudine Meta Metformin Meta
Bromhexine Meta
Budesonide Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Famotidine Meta Nitazoxanide Meta
Favipiravir Meta Paxlovid Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Recovery time 74% Improvement Relative Risk Ivermectin  Aref et al.  LATE TREATMENT  RCT  LONG COVID Does ivermectin reduce the risk of Long COVID (PASC)? RCT 96 patients in Egypt (March - April 2021) Faster recovery with ivermectin (p=0.0005) c19ivm.org Aref et al., Infection and Drug Resist.., Sep 2022 Favors ivermectin Favors control

Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia

Aref et al., Infection and Drug Resistance, doi:10.2147/IDR.S381715, NCT04951362
Sep 2022  
  Twitter
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
96 patient RCT showing faster resolution of post-COVID anosmia with an ivermectin nanosuspension nasal spray.
5 studies use direct respiratory tract administration Aref, Aref (B), Carvallo, Carvallo (B), Chahla
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
This is the 42nd of 46 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000014.
This is the 92nd of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion).
recovery time, 74.0% lower, relative time 0.26, p < 0.001, treatment 49, control 47, anosmia.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Aref et al., 19 Sep 2022, Randomized Controlled Trial, placebo-controlled, Egypt, peer-reviewed, 9 authors, study period 1 March, 2021 - 30 April, 2021, dosage 2 puffs of 70 μg/mL nasal ivermectin, trial NCT04951362 (history).
Contact: mohammedhosnyhassaan@yahoo.com, mohammedhosnyhassaan@med.svu.edu.eg.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperIvermectinAll
Possible Role of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Recovery of Post-COVID-19 Anosmia
Zaki F Aref, Shamardan Ezz Eldin S Bazeed, Mohammed H Hassan, Abeer S Hassan, Ali A Ghweil, Mennatallah Ali Abdelrhman Sayed, Alaa Rashad, Haggagy Mansour, Aida A Abdelmaksoud
Infection and Drug Resistance, doi:10.2147/idr.s381715
Anosmia or hyposmia, with or without taste changes, are common symptoms that occur in SARS-CoV-2 infection and frequently persist as post-COVID-19 manifestations. This is the first trial to assess the potential value of using local ivermectin in the form of a mucoadhesive nanosuspension nasal spray to treat post-COVID-19 anosmia. Methods: It is a controlled, randomized trial. Participants were recruited from South Valley University Hospitals in Qena, Upper Egypt, from the ENT and Chest Diseases Departments and outpatient clinics. Patients with persistent post COVID-19 anosmia were randomly divided into two groups, the first group "ivermectin group" included 49 patients treated by ivermectin nanosuspension mucoadhesive nasal spray (two puffs per day). The second group included 47 patients "placebo group" who received saline nasal spray. Follow-up of anosmia [using Visual analogue scale (VAS)] in all patients for three months or appearance of any drug related side effects was done. Results: The mean duration of pre-treatment post COVID-19 anosmia was 19.5± 5.8 days in the ivermectin group and 19.1± 5.9 days in the placebo group,p˃0.05. Regarding the median duration of anosmia recovery, the ivermectin group recovered from post COVID-19 anosmia in 13 days compared to 50 days in the placebo group, p˂ 0.001. Following the first week of ivermectin nanosuspension mucoadhesive nasal spray therapy, the ivermectin group had a significantly higher percentage of anosmia recovery (59.2%) than the placebo group (27.7%), p˂ 0.01, with no significant differences in recovery rates between the two groups at 1, 2, and 3 months of follow up, p˃0.05. Conclusion: In the small number of patients treated, local Ivermectin exhibited no side effects. In persistent post-COVID-19 anosmia, it could be used for one week at the most as the treatment was extended to one, two and three months, with no difference in recovery compared to the placebo treatment. Trial Registration No: NCT04951362.
Consent for Publication Not applicable because the manuscript lacked the names, identifiers, or images of the patients. Consent for Participation After thorough explanation of the study's objectives and procedures, informed written consent was obtained from each participant in the trial, or from relatives if the patients were less than 18 years old and those who supplied consent on their behalf were their parents or legal guardians. Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Disclosure The authors report no conflicts of interest in relation to this work. Infection and Drug Resistance Dovepress
References
Abdelmaksoud, Ghweil, Hassan, Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: possible Role of Zinc, Biol Trace Elem Res
Ahmed, Karim, Ross, A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness, Int J Infect Dis, doi:10.1016/j.ijid.2020.11.191
Alshweiat, Ambrus, Csoka, Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery, Curr Med Chem, doi:10.2174/0929867326666190827151741
Alshweiat, Csóka, Tömösi, Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: preparation, characterization, and in vivo evaluation, Int J Pharm, doi:10.1016/j.ijpharm.2020.119166
Arbour, Day, Newcombe, Talbot, Neuroinvasion by human respiratory coronaviruses, J Virol, doi:10.1128/JVI.74.19.8913-8921.2000
Aref, Bazeed, Hassan, Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19, Int J Nanomedicine, doi:10.2147/IJN.S313093
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 invitro, Antiviral Res, doi:10.1016/j.antiviral.2020.104787
Canga, Prieto, Liébana, Martínez, Vega et al., The pharmacokinetics and interactions of ivermectin in humans--a mini-review, AAPS J, doi:10.1208/s12248-007-9000-9
Carfì, Bernabei, Landi, Gemelli, Against COVID-19 Post-Acute Care Study Group. Persistent Symptoms in Patients After Acute COVID-19, JAMA, doi:10.1001/jama.2020.12603
Cazzolla, Lovero, Muzio, Taste and Smell Disorders in COVID-19 Patients: role of Interleukin-6, ACS Chem. Neurosci
Chong, Head, Hopkins, Saline irrigation for chronic rhinosinusitis, Cochrane Database Syst Rev, doi:10.1002/14651858.CD011995.pub2
Ci, Li, Yu, Avermectin exerts anti-inflammatory effect by downregulating the nuclear transcription factor kappa-B and mitogen-activated protein kinase activation pathway, Fundam Clin Pharmacol, doi:10.1111/j.1472-8206.2009.00684.x
Dou, Chen, Wang, Iver-mectin induces cytostatic autophagy by blocking the PAK1/Aktaxis in breast cancer, Cancer Res, doi:10.1158/0008-5472.CAN-15-2887
El-Mahdy, Hassan, El-Badry, El-Gindy, Performance of curcumin in nanosized carriers niosomes and ethosomes as potential anti-inflammatory delivery system for topical application, Bull Pharm Sci Assiut, doi:10.21608/bfsa.2020.93599
Fodoulian, Tuberosa, Rossier, SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain, iScience, doi:10.1016/j.isci.2020.101839
Gane, Kelly, Hopkins, Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?, Rhinology, doi:10.4193/Rhin20.114
Gu, Gong, Zhang, Multiple organ infection and the pathogenesis of SARS, J Exp Med, doi:10.1084/jem.20050828
Götz, Magar, Dornfeld, Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import, Sci Rep, doi:10.1038/srep23138
Hamming, Timens, Bulthuis, Lely, Navis et al., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, J Pathol, doi:10.1002/path.1570
Han, Mukdad, Long, Lopez, Anosmia in COVID-19: mechanisms and Significance, Chem Senses, doi:10.1093/chemse/bjaa040
Hung, Chim, Chan, Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome, Clin Chem, doi:10.1373/clinchem.2003.025437
Junior, Cardoso, Giufrida, De Souza, Cardozo-Filho, Production and computational fluid dynamics-based modeling of PMMA nanoparticles impregnated with ivermectin by a supercritical antisolvent process, J CO2 Util, doi:10.1016/j.jcou.2019.08.025
Ketkar, Yang, Wormser, Wang, Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system, Diagn Microbiol Infect Dis, doi:10.1016/j.diagmicrobio.2019.03.012
Kow, Merchant, Mustafa, Hasan, The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis, Pharmacol Rep, doi:10.1007/s43440-021-00245-z
Lozada-Nur, Chainani-Wu, Fortuna, Sroussi, Dysgeusia in COVID-19: possible Mechanisms and Implications, Oral Surg Oral Med Oral Pathol Oral Radiol, doi:10.1016/j.oooo.2020.06.016
López-Medina, López, Hurtado, Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: a Randomized Clinical Trial, JAMA, doi:10.1001/jama.2021.3071
Maraie, Almajidi, Application of nanoemulsion technology for preparation and evaluation of intranasal mucoadhesive nano-in-situ gel for ondansetron HCl, J Glob Pharm Technol
Mastrangelo, Pezzullo, Burghgraeve, Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug, J Antimicrob Chemother, doi:10.1093/jac/dks147
Prajapati, Shahrvini, Macdonald, Association of subjective olfactory dysfunction and 12-item odor identification testing in ambulatory COVID-19 patients, Int Forum Allergy Rhinol, doi:10.1002/alr.22688
Saindane, Pagar, Vavia, Nanosuspension based in situ gelling nasal spray of carvedilol: development, in vitro and in vivo characterization, AAPS PharmSciTech, doi:10.1208/s12249-012-9896-y
Stewart, Mounir, Talbot, Human coronavirus gene expression in the brains of multiple sclerosis patients, Virology, doi:10.1016/0042-6822(92)90220-J
Vaira, Salzano, Fois, Piombino, Riu, Potential pathogenesis of ageusia and anosmia in COVID-19 patients, Int Forum Allergy Rhinol, doi:10.1002/alr.22593
Vallejos, Zoni, Bangher, Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial, BMC Infect Dis, doi:10.1186/s12879-021-06348-5
Van Riel, Verdijk, Kuiken, The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system, J Pathol, doi:10.1002/path.4461
Ventre, Rozières, Lenief, Topical ivermectin improves allergic skin inflammation, Allergy, doi:10.1111/all.13118
Weiss, Murdoch, Clinical course and mortality risk of severe COVID-19, Lancet, doi:10.1016/S0140-6736(20)30633-4
Whittaker, Anson, Harky, Neurological Manifestations of COVID-19: a systematic review and current update, Acta Neurol Scand, doi:10.1111/ane.13266
Xia, Quan, Piao, Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability, Eur J Pharm Sci, doi:10.1016/j.ejps.2010.04.006
Yildiz, Yildiz, Kuzu, Günebakan, Bucak et al., Comparison of the Healing Effect of Nasal Saline Irrigation with Triamcinolone Acetonide Versus Nasal Saline Irrigation alone in COVID-19 Related Olfactory Dysfunction: a Randomized Controlled Study, Indian J Otolaryngol Head Neck Surg, doi:10.1007/s12070-021-02749-9
Zhang, Song, Xiong, Inhibitory effects of ivermectin on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 macrophages, Int Immunopharmacol, doi:10.1016/j.intimp.2008.12.016
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of over 100,000 datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit