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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Case 96% Improvement Relative Risk Ivermectin for COVID-19  Carvallo et al.  Prophylaxis Does ivermectin + iota-carrageenan reduce COVID-19 infections? Prospective study of 229 patients in Argentina Fewer cases with ivermectin + iota-carrageenan (p=0.000063) c19ivm.org Carvallo et al., NCT04425850, October 2020 Favors ivermectin Favors control

Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR)

Carvallo et al., NCT04425850, NCT04425850
Oct 2020  
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Prophylaxis study using ivermectin and carrageenan showing 0 of 131 cases from treated healthcare workers, compared to 11 of 98 control.
The effect is likely to be primarily due to ivermectin - the author has later reported that carrageenan is not necessary youtube.com.
See doyourownresearch.substack.com for discussion of issues with this trial.
5 studies use direct respiratory tract administration Aref, Aref (B), Carvallo, Carvallo (B), Chahla
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
This is the 13th of 99 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 2 sextillion). 46 studies are RCTs, which show efficacy with p=0.00000014.
This study is excluded in the after exclusion results of meta analysis: concern about potential data issues.
risk of case, 96.3% lower, RR 0.04, p < 0.001, treatment 0 of 131 (0.0%), control 11 of 98 (11.2%), NNT 8.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Carvallo et al., 19 Oct 2020, prospective, Argentina, preprint, 1 author, dosage 1mg days 1-14, this trial uses multiple treatments in the treatment arm (combined with iota-carrageenan) - results of individual treatments may vary, trial NCT04425850 (history).
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