Carvallo: Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR)

Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR)

Carvallo et al., NCT04425850 (Preprint)

Carvallo et al., Usefulness of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid 19 (IVERCAR), NCT04425850 (Preprint)

Oct 2020 Source PDF

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Prophylaxis study using ivermectin and carrageenan showing 0 of 131 cases from treated healthcare workers, compared to 11 of 98 control.

The effect is likely to be primarily due to ivermectin - the author has later reported that carrageenan is not necessary [youtube.com].

See [doyourownresearch.substack.com] for discussion of issues with this trial. This study is excluded in the after exclusion results of meta analysis: concern about potential data issues.

1. doyourownresearch.substack.com, https://doyourownresearch.substack..otemkin-argument-part-vii-together.

2. youtube.com, https://www.youtube.com/watch?v=CB6Bvi_g-w8.

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risk of case, 96.3% lower, RR 0.04, p < 0.001, treatment 0 of 131 (0.0%), control 11 of 98 (11.2%), NNT 8.9, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Carvallo et al., 19 Oct 2020, prospective, Argentina, preprint, 1 author, dosage 1mg days 1-14, this trial uses multiple treatments in the treatment arm (combined with iota-carrageenan) - results of individual treatments may vary.

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