Clinical-Epidemiology Aspect of Inpatients With Moderate or Severe COVID-19 in a Brazilian Macroregion: Disease and Countermeasures
Silva et al.,
Clinical-Epidemiology Aspect of Inpatients With Moderate or Severe COVID-19 in a Brazilian Macroregion:..,
Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2022.899702
Retrospective 395 hospitalized patients in Brazil, showing mortality HR 0.59 for antiparasitic use, however there were only 8 patients treated and authors do not distinguish between albendazole and ivermectin.
risk of death, 32.3% lower, RR 0.68, p = 0.57, treatment 8, control 387, adjusted per study, odds ratio converted to relative risk, ivermectin or albendazole, multivariable, control prevalance approximated with overall prevalence.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Silva et al., 20 May 2022, retrospective, Brazil, peer-reviewed, mean age 58.4, 28 authors, study period 25 March, 2020 - 21 October, 2020.
Contact:
pos-doc.rodrigues@uftm.edu.br.
Abstract: ORIGINAL RESEARCH
published: 20 May 2022
doi: 10.3389/fcimb.2022.899702
Edited by:
Rodrigo Ivo Santos,
North Carolina State University,
United States
Reviewed by:
Rafael Kroon Campos,
University of Texas Medical Branch at
Galveston, United States
Adam Ronk,
Battelle, United States
*Correspondence:
Wellington Francisco Rodrigues
pos-doc.rodrigues@uftm.edu.br
†
These authors have contributed
equally to this work
Specialty section:
This article was submitted to
Clinical Microbiology,
a section of the journal
Frontiers in Cellular and
Infection Microbiology
Received: 19 March 2022
Accepted: 19 April 2022
Published: 20 May 2022
Citation:
Silva BRO, Rodrigues WF,
Abadia DGP, Alves da Silva DA,
Andrade e Silva LE, Desidério CS,
Farnesi-de-Assunção TS,
Costa-Madeira JC, Barbosa RM,
Bernardes e Borges AV,
Hortolani Cunha ACC, Pereira LQ,
Helmo FR, Lemes MR, Barbosa LM,
Trevisan RO, Obata MMS, Bueno GF,
Mundim FV, Oliveira-Scussel ACM,
Monteiro IB, Ferreira YM,
Machado GH, Ferreira-Paim K,
Moraes-Souza H, da Silva MV,
Rodrigues Júnior V and Oliveira CJF
(2022) Clinical-Epidemiology Aspect of
Inpatients With Moderate or Severe
COVID-19 in a Brazilian Macroregion:
Disease and Countermeasures.
Front. Cell. Infect. Microbiol. 12:899702.
doi: 10.3389/fcimb.2022.899702
Clinical-Epidemiology Aspect of
Inpatients With Moderate or Severe
COVID-19 in a Brazilian Macroregion:
Disease and Countermeasures
Bruna Raphaela Oliveira Silva 1†, Wellington Francisco Rodrigues 1*†,
Daniela Gomes Pires Abadia 1, Djalma A. Alves da Silva 1, Leonardo E. Andrade e Silva 1,
Chamberttan S. Desidério 1, Thais Soares Farnesi-de-Assunção 1,
Juliana C. Costa-Madeira 1, Rafaela M. Barbosa 1, Anna V. Bernardes e Borges 1,
Andrezza C. C. Hortolani Cunha 2, Loren Q. Pereira 3, Fernanda R. Helmo 1,
Marcela Rezende Lemes 1, Laı́s M. Barbosa 1, Rafael O. Trevisan 1,
Malu Mateus Santos Obata 1, Giovanna F. Bueno 1, Fabiano V. Mundim 1,
Ana Carolina M. Oliveira-Scussel 1, Ivan B. Monteiro 4,5, Yulsef M. Ferreira 5,
Guilherme H. Machado 6, Kennio Ferreira-Paim 1, Hélio Moraes-Souza 3,
Marcos Vinicius da Silva 1, Virmondes Rodrigues Júnior 1 and Carlo José Freire Oliveira 1
1 Department of Immunology, Microbiology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil,
2 Postgraduate Program in Physiological Sciences, Federal University of Triângulo Mineiro, Uberaba, Brazil, 3 Laboratory of
Hematological Research of the Federal University of Triângulo Mineiro and Regional Blood Center of Uberaba - Hemominas
Foundation, Uberaba, Brazil, 4 UNIMED São Domingos Hospital, Uberaba, MG, Brazil. José Alencar Gomes da Silva
Regional Hospital, Uberaba, Brazil, 5 José Alencar Gomes da Silva Regional Hospital, Uberaba, Brazil, 6 Mário Palmério
University Hospital, Uberaba, Brazil
COVID-19, also known as coronavirus disease 2019, is an infectious viral disease caused by
SARS-CoV-2, a novel coronavirus. Since its emergence, its epidemiology has been explored;
however, for some regions of the world, COVID-19’s behavior, incidence, and impact remain
unclear. In continental nations like Brazil, this lack of knowledge results in nonuniform control,
prevention, and treatment measures, which can be controversial in some locations. This
study aimed to describe the epidemiological profile of patients with COVID-19 in the
macroregion of Triâ ngulo Sul in the state of Minas Gerais (MG), Brazil. Between March 25
and October 21, 2020, data were collected and statistically analyzed..
Late treatment
is less effective
silva3
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