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All Studies   Meta Analysis    Recent:   

Ivermectin for COVID-19: real-time meta analysis of 101 studies (ivmmeta)

Covid Analysis
Feb 2024  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 101 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19ivm.org
Statistically significant lower risk is seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain significant for higher quality studies. 61 studies from 55 independent teams in 25 different countries show statistically significant improvements.
Meta analysis using the most serious outcome shows 62% [51‑70%] and 85% [77‑90%] lower risk for early treatment and prophylaxis, with similar results for higher quality studies,
primary outcomes, peer-reviewed studies, and for RCTs.
Results are very robust — in worst case exclusion sensitivity analysis 61 of 101 studies must be excluded to avoid finding statistically significant efficacy.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, which may be significantly more effective. Pharmacokinetics show significant inter-individual variability Guzzo. Efficacy may vary depending on the manufacturer Williams.
Over 20 countries adopted ivermectin for COVID-19. The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
All data to reproduce this paper and sources are in the appendix. Multiple other meta analyses show efficacy Bryant, Hariyanto, Kory, Lawrie, Nardelli.
7 meta analyses show significant improvements with ivermectin for mortality Bryant, Hariyanto, Kory, Lawrie, Nardelli, Zein, hospitalization Schwartz, recovery Kory, and cases Kory.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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