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0 0.5 1 1.5 2+ Mortality 57% Improvement Relative Risk Ventilation -34% ICU admission -37% primary c19ivm.org Ochoa-Jaramillo et al. NCT04602507 Ivermectin RCT LATE Favors ivermectin Favors control
Clinical efficacy and safety of ivermectin (400 μg/kg, single dose) in patients with severe COVID-19: a randomized clinical trial
Ochoa-Jaramillo et al., Revista Infectio, NCT04602507 (history)
21 Oct 2022    Source   PDF   Share   Tweet
RCT 75 very late stage patients in Colombia, showing no significant difference in outcomes with a single dose of 400μg/kg ivermectin.
Although the 57% lower mortality is not statistically significant, it is consistent with the significant 51% lower mortality [37‑62%] from meta analysis of the 48 mortality results to date.
risk of death, 57.0% lower, HR 0.43, p = 0.35, treatment 2 of 37 (5.4%), control 4 of 38 (10.5%), NNT 20, Cox proportional hazards.
risk of mechanical ventilation, 34.0% higher, HR 1.34, p = 0.62, treatment 7 of 37 (18.9%), control 5 of 38 (13.2%), Cox proportional hazards.
risk of ICU admission, 37.0% higher, HR 1.37, p = 0.52, treatment 8 of 37 (21.6%), control 6 of 38 (15.8%), Cox proportional hazards, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ochoa-Jaramillo et al., 21 Oct 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Colombia, peer-reviewed, 8 authors, average treatment delay 8.8 days, dosage 400μg/kg single dose, trial NCT04602507 (history).
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Late treatment
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