Novel non-covalent ivermectin complex Didenectin is revolutionizing healthcare
Kirill Didenko
doi:10.5281/zenodo.10215620
COVID-19 pandemic has accelerated scientific knowledge and led to groundbreaking advancements in virology, and it has also given rise development of new viruses based on the coronavirus both in governmental and private laboratories all over the world. Laboratory accidents, no matter how well-controlled, can happen. We need to explore a development of an effective treatment that can mitigate the potential misuse of the coronavirus as a foundation for new viruses. In this article, we introduce a revolutionary breakthrough in coronavirus treatment, new ivermectin-based complex Didenectin (antiviral ivermectin), which is proved to reduce virus load to 100 times during 24h, leading to revolutionary rapid recovery of SARS-CoV-2 patients and Dengue patients within a record 24-hour timeframe. The newly developed ivermectin-polymer complex, known as Didenectin, is derived from an innovative solid dispersion of ivermectin formed through the novel process of mechanochemical activation. This complex combines with arabinogalactan polymer to create a non-covalent interaction. The ivermectin-polymer complex Didenectin, due to its modified molecular structure, exhibits altered properties, including a 20-fold increase in solubility, increased bioavailability, enhanced permeability, and, simultaneously, a 3.4-fold reduction in oral toxicity compare to ordinary ivermectin. The substantial changes in drug parameters compared to the base compound result in a qualitatively new treatment outcome and results in a significant 100 times reduction in the viral load within the initial 24-hour period. Instead of merely improving treatment efficacy indicators, such as ventilation, ICU admissions, hospitalization, and recovery, the treatment led to the complete recovery of patients in the shortest time possible. The treatment duration for the infection is reduced to just 1 day at a single dose of more than 600-700 μg/kg (according to pure IVM). As ivermectin is under investigation as an anticancer agent, Didenectin emerges as a promising candidate for cancer treatment due to its low toxicity. * -Doses and concentrations highlighted in bold were used to construct a dose-C max linear regression. † -Theoretical calculated doses estimated based on linear regression. 1 -The ingested amount (in μg/kg/day) was derived from an estimated body weight of 75 kg for patients with unknown body weight. 2 -Calculated by plasma-lung ratio 2.67 [2]. ‡ -Maximum single dose have been used in a trial in healthy volunteers without clinically significant safety issues [6].
Table 15 . Documented in vitro antiviral action of ivermectin [13] .
Virus InhibitoryConcentration / Foldreduction According to studies, Ivermectin has broad anticancer activity and has antitumor effects in vitro and in vivo [19, 20, 21] . Didenectin emerges as a promising candidate for cancer treatment due to its low toxicity.
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