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Novel non-covalent ivermectin complex Didenectin is revolutionizing healthcare

Didenko, K., Zenodo, doi:10.5281/zenodo.10215620
Nov 2023  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now with p < 0.00000000001 from 104 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Report on a non-covalent complex of ivermectin called Didenectin, showing improved solubility and lower toxicity in animals, and promising results in early testing for SARS-CoV-2 and Dengue.
Didenko et al., 29 Nov 2023, peer-reviewed, 1 author. Contact:
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Novel non-covalent ivermectin complex Didenectin is revolutionizing healthcare
Kirill Didenko
COVID-19 pandemic has accelerated scientific knowledge and led to groundbreaking advancements in virology, and it has also given rise development of new viruses based on the coronavirus both in governmental and private laboratories all over the world. Laboratory accidents, no matter how well-controlled, can happen. We need to explore a development of an effective treatment that can mitigate the potential misuse of the coronavirus as a foundation for new viruses. In this article, we introduce a revolutionary breakthrough in coronavirus treatment, new ivermectin-based complex Didenectin (antiviral ivermectin), which is proved to reduce virus load to 100 times during 24h, leading to revolutionary rapid recovery of SARS-CoV-2 patients and Dengue patients within a record 24-hour timeframe. The newly developed ivermectin-polymer complex, known as Didenectin, is derived from an innovative solid dispersion of ivermectin formed through the novel process of mechanochemical activation. This complex combines with arabinogalactan polymer to create a non-covalent interaction. The ivermectin-polymer complex Didenectin, due to its modified molecular structure, exhibits altered properties, including a 20-fold increase in solubility, increased bioavailability, enhanced permeability, and, simultaneously, a 3.4-fold reduction in oral toxicity compare to ordinary ivermectin. The substantial changes in drug parameters compared to the base compound result in a qualitatively new treatment outcome and results in a significant 100 times reduction in the viral load within the initial 24-hour period. Instead of merely improving treatment efficacy indicators, such as ventilation, ICU admissions, hospitalization, and recovery, the treatment led to the complete recovery of patients in the shortest time possible. The treatment duration for the infection is reduced to just 1 day at a single dose of more than 600-700 μg/kg (according to pure IVM). As ivermectin is under investigation as an anticancer agent, Didenectin emerges as a promising candidate for cancer treatment due to its low toxicity. * -Doses and concentrations highlighted in bold were used to construct a dose-C max linear regression. † -Theoretical calculated doses estimated based on linear regression. 1 -The ingested amount (in μg/kg/day) was derived from an estimated body weight of 75 kg for patients with unknown body weight. 2 -Calculated by plasma-lung ratio 2.67 [2]. ‡ -Maximum single dose have been used in a trial in healthy volunteers without clinically significant safety issues [6].
Table 15 . Documented in vitro antiviral action of ivermectin [13] . Virus InhibitoryConcentration / Foldreduction According to studies, Ivermectin has broad anticancer activity and has antitumor effects in vitro and in vivo [19, 20, 21] . Didenectin emerges as a promising candidate for cancer treatment due to its low toxicity.
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{ 'type': 'article', 'id': '', 'language': 'en', 'author': [{'family': 'Didenko', 'given': 'Kirill'}], 'issued': {'date-parts': [[2023, 11, 29]]}, 'abstract': 'In this article, we introduce a revolutionary breakthrough in coronavirus treatment, new ' 'ivermectin-based complex Didenectin (antiviral ivermectin), which is proved to reduce virus ' 'load to 100 times during 24h, leading to revolutionary rapid recovery of SARS-CoV-2 patients ' 'and Dengue patients within a record 24-hour timeframe.\n' 'The introduction of new non-covalent complex of ivermectin is changing the game in the ' 'healthcare industry. A novel non-covalent ivermectin-polymer complex Didenectin, already ' 'showed remarkable results on SARS-CoV-2 as well as on Dengue, a condition currently lacking ' 'any specific treatment. The complex should also be effective for the treatment of other viral ' 'infections that have shown in vitro sensitivity to ivermectin such as Chikungunya, Zika, ' 'Yellow fever, West Nile, avian influenza A (H7N7), HIV-1, Japanese encephalitis, tick-borne ' 'encephalitis, Epstein-Barr and others.\n' 'Ivermectin, a widely recognized anti-parasitic medication, exhibited remarkable efficacy in ' 'reducing viral load of SARS-CoV-2 by 93% and more within a single day under in vitro ' 'conditions, as demonstrated by Caly et al. However, translating these results to in vivo ' 'human studies was hindered by the substantial toxicity of ivermectin, preventing the ' 'achievement of the necessary\xa0IC50 2.4 μM and IC90 5 μM\xa0concentration of\xa0' 'ivermectin\xa0in body tissues. The advent of the innovative Didenectin allowed to achieve a ' 'notable 3.4-fold reduction in oral toxicity and a remarkable 20-fold increase in solubility ' 'when compared to standard ivermectin. This led to the achievement of necessary\xa0IC50 2.4 μM ' 'and IC90 5 μM\xa0concentration of\xa0ivermectin\xa0and comparable reduction in viral load in ' 'vivo as previously demonstrated in vitro by Caly et al.\n' "Didenectin's rapid and effective action demonstrates its potential not only for SARS-CoV-2\xa0" 'but potentially for Dengue as well. The first-ever cure of a Dengue patient within a 24-hour ' 'timeframe using Didenectin represents a monumental achievement in the field of antiviral ' 'research.\n' "This article delves into the complex's mechanism of action, pre-clinical results, as well as " 'a detailed description of the method for obtaining the ivermectin-polymer complex Didenectin, ' 'along with the complete formula and table of dosages.', 'DOI': '10.5281/ZENODO.10215620', 'publisher': 'Zenodo', 'title': 'Novel non-covalent ivermectin complex Didenectin is revolutionizing healthcare.', 'URL': '', 'copyright': 'Creative Commons Attribution 4.0 International', 'version': '1'}
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