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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Ventilation, 24mg 67% Improvement Relative Risk Ventilation, 12mg 33% Hospitalization, 24mg 46% primary Hospitalization, 12mg 27% primary Recovery, 24mg 39% Recovery, 12mg 31% Recovery time, 24mg 0% no CI Recovery time, 12mg 0% no CI c19ivm.org Mirahmadizadeh et al. Ivermectin for COVID-19 RCT EARLY Favors ivermectin Favors control
Efficacy of single‐dose and double‐dose ivermectin early treatment in preventing progression to hospitalization in mild COVID ‐19: A multi‐arm, parallel‐group randomized, double‐blind, placebo‐controlled trial
Mirahmadizadeh et al., Respirology, doi:10.1111/resp.14318
23 Jun 2022    Source   PDF   Share   Tweet
RCT with 131 24mg ivermectin, 130 12mg ivermectin, and 130 placebo patients, showing no significant differences in outcomes. Lower ventilation and hospitalization was seen with treatment, in a dose-dependent manner, but not reaching statistical significance with the small number of events.
risk of mechanical ventilation, 66.9% lower, RR 0.33, p = 0.37, treatment 1 of 131 (0.8%), control 3 of 130 (2.3%), NNT 65, 24mg.
risk of mechanical ventilation, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 130 (1.5%), control 3 of 130 (2.3%), NNT 130, 12mg.
risk of hospitalization, 45.9% lower, RR 0.54, p = 0.22, treatment 6 of 131 (4.6%), control 11 of 130 (8.5%), NNT 26, 24mg, primary outcome.
risk of hospitalization, 27.3% lower, RR 0.73, p = 0.63, treatment 8 of 130 (6.2%), control 11 of 130 (8.5%), NNT 43, 12mg, primary outcome.
risk of no recovery, 38.9% lower, RR 0.61, p = 0.27, treatment 8 of 131 (6.1%), control 13 of 130 (10.0%), NNT 26, day 28, 24mg.
risk of no recovery, 30.8% lower, RR 0.69, p = 0.50, treatment 9 of 130 (6.9%), control 13 of 130 (10.0%), NNT 32, day 28, 12mg.
recovery time, no change, relative time 1.00, treatment 131, control 130, 24mg.
recovery time, no change, relative time 1.00, treatment 130, control 130, 12mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mirahmadizadeh et al., 23 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors, study period 9 April, 2021 - 20 May, 2021, dosage 24mg single dose, 12mg and 24mg arms.
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