All Studies Meta Analysis Recent:

Efficacy of single-dose and double-dose ivermectin early treatment in preventing progression to hospitalization in mild COVID-19: A multi-arm, parallel-group randomized, double-blind, placebo-controlled trial

Mirahmadizadeh et al., Respirology, doi:10.1111/resp.14318

Jun 2022

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Download Image

Ivermectin for COVID-19

4th treatment shown to reduce risk in August 2020

^*, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.

Lower risk for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments. ^* >10% efficacy, ≥3 studies.

4,500+ studies for 81 treatments. c19ivm.org

RCT with 131 24mg ivermectin, 130 12mg ivermectin, and 130 placebo patients, showing no significant differences in outcomes. Lower ventilation and hospitalization was seen with treatment, in a dose-dependent manner, but not reaching statistical significance with the small number of events.

This is the 39th of 52 COVID-19 RCTs for ivermectin, which collectively show efficacy with p=0.00000021.

This is the 88th of 105 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 774 quintillion).

Important missing comments or errors? Let us know.

risk of mechanical ventilation, 66.9% lower, RR 0.33, p = 0.37, treatment 1 of 131 (0.8%), control 3 of 130 (2.3%), NNT 65, 24mg.

risk of mechanical ventilation, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 130 (1.5%), control 3 of 130 (2.3%), NNT 130, 12mg.

risk of hospitalization, 45.9% lower, RR 0.54, p = 0.22, treatment 6 of 131 (4.6%), control 11 of 130 (8.5%), NNT 26, 24mg, primary outcome.

risk of hospitalization, 27.3% lower, RR 0.73, p = 0.63, treatment 8 of 130 (6.2%), control 11 of 130 (8.5%), NNT 43, 12mg, primary outcome.

risk of no recovery, 38.9% lower, RR 0.61, p = 0.27, treatment 8 of 131 (6.1%), control 13 of 130 (10.0%), NNT 26, day 28, 24mg.

risk of no recovery, 30.8% lower, RR 0.69, p = 0.50, treatment 9 of 130 (6.9%), control 13 of 130 (10.0%), NNT 32, day 28, 12mg.

recovery time, no change, relative time 1.00, treatment 131, control 130, 24mg.

recovery time, no change, relative time 1.00, treatment 130, control 130, 12mg.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Mirahmadizadeh et al., 23 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors, study period 9 April, 2021 - 20 May, 2021, dosage 24mg single dose, 12mg and 24mg arms.

This Paper Ivermectin All

{ 'indexed': {'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T01:41:33Z', 'timestamp': 1656034893495}, 'reference-count': 35, 'publisher': 'Wiley', 'license': [ { 'start': { 'date-parts': [[2022, 6, 23]], 'date-time': '2022-06-23T00:00:00Z', 'timestamp': 1655942400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}, { 'start': { 'date-parts': [[2022, 6, 23]], 'date-time': '2022-06-23T00:00:00Z', 'timestamp': 1655942400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'http://doi.wiley.com/10.1002/tdm_license_1.1'}], 'funder': [ { 'DOI': '10.13039/501100004320', 'name': 'Shiraz University of Medical Sciences', 'doi-asserted-by': 'publisher', 'award': ['99‐7850']}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'DOI': '10.1111/resp.14318', 'type': 'journal-article', 'created': {'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T00:59:40Z', 'timestamp': 1656032380000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Efficacy of single‐dose and double‐dose ivermectin early treatment in preventing progression to ' 'hospitalization in mild\n' ' <scp>COVID</scp>\n' ' ‐19: A multi‐arm, parallel‐group randomized, double‐blind, placebo‐controlled trial', 'prefix': '10.1111', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2259-4984', 'authenticated-orcid': False, 'given': 'Alireza', 'family': 'Mirahmadizadeh', 'sequence': 'first', 'affiliation': [ { 'name': 'Non‐communicable Diseases Research Center Shiraz University of ' 'Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6322-7876', 'authenticated-orcid': False, 'given': 'Ali', 'family': 'Semati', 'sequence': 'additional', 'affiliation': [ { 'name': 'Non‐communicable Diseases Research Center Shiraz University of ' 'Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6567-5306', 'authenticated-orcid': False, 'given': 'Alireza', 'family': 'Heiran', 'sequence': 'additional', 'affiliation': [ { 'name': 'Non‐communicable Diseases Research Center Shiraz University of ' 'Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0003-2724-039X', 'authenticated-orcid': False, 'given': 'Mostafa', 'family': 'Ebrahimi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Communicable Diseases Control Center Shiraz University of ' 'Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9951-8341', 'authenticated-orcid': False, 'given': 'Abdolrasool', 'family': 'Hemmati', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Affairs Shiraz University of Medical ' 'Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1435-3996', 'authenticated-orcid': False, 'given': 'Mohammadreza', 'family': 'Karimi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Affairs Shiraz University of Medical ' 'Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-8474-8822', 'authenticated-orcid': False, 'given': 'Souzan', 'family': 'Basir', 'sequence': 'additional', 'affiliation': [{'name': 'Shiraz University of Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0199-3230', 'authenticated-orcid': False, 'given': 'Marjan', 'family': 'Zare', 'sequence': 'additional', 'affiliation': [ { 'name': 'Non‐communicable Diseases Research Center Shiraz University of ' 'Medical Sciences Shiraz Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5516-5177', 'authenticated-orcid': False, 'given': 'Antonio', 'family': 'Charlys da Costa', 'sequence': 'additional', 'affiliation': [ { 'name': 'Institute of Tropical Medicine, School of Medicine University of ' 'São Paulo São Paulo Brazil'}]}, { 'ORCID': 'http://orcid.org/0000-0003-4233-9275', 'authenticated-orcid': False, 'given': 'Mohammad', 'family': 'Zeinali', 'sequence': 'additional', 'affiliation': [ { 'name': 'National Zoonoses Control Department Ministry of Health and ' 'Medical Education Tehran Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-7689-9866', 'authenticated-orcid': False, 'given': 'Maryam', 'family': 'Sargolzaee', 'sequence': 'additional', 'affiliation': [ { 'name': 'Communicable Diseases Control Center Ministry of Health and ' 'Medical Education Tehran Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5313-1352', 'authenticated-orcid': False, 'given': 'Owrang', 'family': 'Eilami', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Family Medicine and Infectious Diseases Shiraz ' 'University of Medical Sciences Shiraz Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2022, 6, 23]]}, 'reference': [ { 'key': '#cr-split#-e_1_2_10_2_1.1', 'unstructured': 'World Health Organization.COVID‐19: Clinical Care. Therapeutics and ' 'COVID‐19: Living Guideline. [updated 2021 Sep 25'}, { 'key': '#cr-split#-e_1_2_10_2_1.2', 'unstructured': 'cited 2021 Sep 28]. Available ' 'from:https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.2'}, {'key': 'e_1_2_10_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/d41586-020-02360-y'}, {'key': 'e_1_2_10_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/d41586-021-02783-1'}, {'key': 'e_1_2_10_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/d41586-021-03074-5'}, { 'key': 'e_1_2_10_6_1', 'unstructured': 'Bloomberg.Remdesivir Averts Hospitalization in Study of High‐Risk ' 'Patients.2021Sep 22 [cited 2021 Nov 27]. Available ' 'from:https://www.bloomberg.com/news/articles/2021-09-22/remdesivir-averts-hospitalization-in-study-of-high-risk-patients'}, {'key': 'e_1_2_10_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/d41586-021-02054-z'}, {'key': 'e_1_2_10_8_1', 'doi-asserted-by': 'publisher', 'DOI': '10.2183/pjab.87.13'}, { 'key': 'e_1_2_10_9_1', 'unstructured': 'World Health Organization.World Health Organization Model List of ' 'Essential Medicines: 21st List 2019.Geneva:World Health ' 'Organization;2019[cited 2021 Sep 19]. Available ' 'from:https://apps.who.int/iris/bitstream/handle/10665/325771/WHO-MVP-EMP-IAU-2019.06-eng.pdf'}, {'key': 'e_1_2_10_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.pt.2017.02.004'}, {'key': 'e_1_2_10_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/srep23138'}, { 'key': 'e_1_2_10_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2013.10.004'}, { 'key': 'e_1_2_10_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2013.06.002'}, {'key': 'e_1_2_10_14_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1042/BJ20120150'}, { 'key': 'e_1_2_10_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2012.06.008'}, { 'key': 'e_1_2_10_16_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2020.104760'}, {'key': 'e_1_2_10_17_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/jac/dks147'}, { 'key': 'e_1_2_10_18_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2020.104787'}, {'key': 'e_1_2_10_19_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/v13060989'}, {'key': 'e_1_2_10_20_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.2021.3071'}, { 'key': 'e_1_2_10_21_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s13063-020-04813-1'}, {'key': 'e_1_2_10_22_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/jac/dkz524'}, { 'key': 'e_1_2_10_23_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s43440-020-00195-y'}, { 'key': '#cr-split#-e_1_2_10_24_1.1', 'unstructured': 'World Health Organization.COVID‐19 Therapeutic Trial Synopsis Draft. ' '[updated 2020 Feb 18'}, { 'key': '#cr-split#-e_1_2_10_24_1.2', 'unstructured': 'cited 2021 Sep 19]. Available ' 'from:https://www.who.int/publications/i/item/covid-19-therapeutic-trial-synopsis'}, { 'issue': '1', 'key': 'e_1_2_10_25_1', 'first-page': '63', 'article-title': 'A comparative study on ivermectin‐doxycycline and ' 'hydroxychloroquine‐azithromycin therapy on COVID‐19 patients', 'volume': '5', 'author': 'Chowdhury A', 'year': '2021', 'journal-title': 'EJMO'}, { 'key': 'e_1_2_10_26_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/s0895-4356(98)00138-3'}, {'key': 'e_1_2_10_27_1', 'doi-asserted-by': 'publisher', 'DOI': '10.18433/jpps32105'}, { 'key': 'e_1_2_10_28_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijantimicag.2021.106516'}, { 'key': 'e_1_2_10_29_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eclinm.2021.100959'}, { 'key': '#cr-split#-e_1_2_10_30_1.1', 'unstructured': 'World Health Organization.WHO Advises that Ivermectin Only Be Used to ' 'Treat COVID‐19 Within Clinical Trials. [updated 2021 Mar 31'}, { 'key': '#cr-split#-e_1_2_10_30_1.2', 'unstructured': 'cited 2021 Sep 19]. Available ' 'from:https://www.who.int/news-room/feature-stories/detail/who-advises-that-ivermectin-only-be-used-to-treat-covid-19-within-clinical-trials'}, { 'key': 'e_1_2_10_31_1', 'unstructured': 'Centers for Disease Control and Prevention (CDC).Rapid Increase in ' 'Ivermectin Prescriptions and Reports of Severe Illness Associated with ' 'Use of Products Containing Ivermectin to Prevent or Treat COVID‐19. ' '[updated 2021 Aug 26; cited 2021 Sep 19]. Available ' 'from:https://emergency.cdc.gov/han/2021/han00449.asp'}, { 'key': '#cr-split#-e_1_2_10_32_1.1', 'unstructured': 'Google News.Coronavirus (COVID‐19). [updated 2021 Sep 27'}, { 'key': '#cr-split#-e_1_2_10_32_1.2', 'unstructured': 'cited 2021 Oct 2]. Available ' 'from:https://news.google.com/covid19/map?hl=fa&state=7&mid=%2Fm%2F03shp'}], 'container-title': 'Respirology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/resp.14318', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/full-xml/10.1111/resp.14318', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/resp.14318', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T01:00:00Z', 'timestamp': 1656032400000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/resp.14318'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 6, 23]]}, 'references-count': 35, 'alternative-id': ['10.1111/resp.14318'], 'URL': 'http://dx.doi.org/10.1111/resp.14318', 'relation': {}, 'ISSN': ['1323-7799', '1440-1843'], 'subject': ['Pulmonary and Respiratory Medicine'], 'container-title-short': 'Respirology', 'published': {'date-parts': [[2022, 6, 23]]}, 'assertion': [ { 'value': '2021-12-08', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-05-13', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-06-23', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0