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Development and Optimization of Lyophilized Dry Emulsion Tablet for Improved Oral Delivery of Ivermectin

Madawi et al., Journal of Drug Delivery Science and Technology, doi:10.1016/j.jddst.2025.106941, Apr 2025
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 24 countries.
No treatment is 100% effective. Protocols combine treatments.
5,500+ studies for 121 treatments. c19ivm.org
In Vitro and rabbit study showing that rapidly disintegrating lyophilized dry‑emulsion tablets (IVM‑LDET) markedly improve oral ivermectin delivery. Authors applied a quality‑by‑design approach to oil‑in‑water emulsions (sweet almond oil + Span 80/Tween 80), then freeze‑dried them into tablets that disintegrated in seconds, boosting ivermectin solubility 600‑fold and achieving near‑complete dissolution within ten minutes. Pharmacokinetic testing in rabbits (single 6 mg‑equivalent dose) showed a 30% rise in Cmax, a 30% rise in AUC0‑∞, and a 4‑h reduction in Tmax versus the commercial tablet, suggesting higher and faster systemic exposure that could permit lower dosing and better tolerability for COVID‑19 treatment.
7 studies investigate novel formulations of ivermectin for improved efficacy1-7
Madawi et al., 30 Apr 2025, peer-reviewed, 6 authors.
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