Effect of Ivermectin mass drug administration on the COVID-19 Pandemic
Nidhi Uniyal, Hem Chandra Pandey, Ashutosh Sayana, Professor, Narayan Jeet, Professor, Anurag Agrawal, Professor, Sadhana Awasthi, Professor, Saurabh Agarwal, Puneet Kumar Gupta
International journal of health sciences, doi:10.53730/ijhs.v6ns1.4792
Uttarakhand, a hilly state of India adopted the strategy of mass drug administration of ivermectin during the second wave of COVID-19 pandemic as a measure to control the peak due to failing health infrastructure and health facility with sudden cases surge. This study was hereby planned with an aim of analyzing the effect of mass drug administration of ivermectin on the COVID-19 pandemic progression in the State of Uttarakhand. The trend of pandemic progression in five states of India was studied taking case growth rate, active case rate and case fatality rate as indicators. The percentage change in the indicators with the progression of pandemic was calculated for all five states and compared. The projected increased number of deaths, the state of Uttarakhand would have experienced, if the state had the declining average case growth of the other states taken for study was also calculated. The data analysis shows that the Uttarakhand had a sharp fall in the active cases by 3 to 4 weeks post lockdown, the period corresponding with maximum coverage of ivermectin distribution in the state, compared to four other states. Uttarakhand was also able to control the rising case fatality rate in state, by early decline in case growth rate and also partly due to decrease in severity of cases, as ivermectin is hypothesized to affect disease severity if given as early treatment. The study observed that mass drug administration of ivermectin had beneficial effect on the pandemic control in the state of Uttarakhand.
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'abstract': '<jats:p>Uttarakhand, a hilly state of India adopted the strategy of mass drug administration '
'of ivermectin during the second wave of COVID-19 pandemic as a measure to control the peak '
'due to failing health infrastructure and health facility with sudden cases surge. This study '
'was hereby planned with an aim of analyzing the effect of mass drug administration of '
'ivermectin on the COVID-19 pandemic progression in the State of Uttarakhand. The trend of '
'pandemic progression in five states of India was studied taking case growth rate, active case '
'rate and case fatality rate as indicators. The percentage change in the indicators with the '
'progression of pandemic was calculated for all five states and compared. The projected '
'increased number of deaths, the state of Uttarakhand would have experienced, if the state had '
'the declining average case growth of the other states taken for study was also calculated. '
'The data analysis shows that the Uttarakhand had a sharp fall in the active cases by 3 to 4 '
'weeks post lockdown, the period corresponding with maximum coverage of ivermectin '
'distribution in the state.</jats:p>',
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