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All Studies   Meta Analysis    Recent:   

Effect of Ivermectin mass drug administration on the COVID-19 Pandemic

Uniyal et al., International Journal of Health Sciences, doi:10.53730/ijhs.v6nS1.4792
Mar 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19ivm.org
Analysis of mass administration of ivermectin for COVID-19 in Uttarakhand compared to four other states not adopting ivermectin, showing a sharp fall in cases compared to the other states at the time of maximum coverage of ivermectin distribution, and an inverse correlation between ivermectin coverage and positivity rate.
Uniyal et al., 15 Mar 2022, retrospective, India, peer-reviewed, 8 authors. Contact: sagarwal685@gmail.com.
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AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for ivermectin.

Mass drug administration of ivermectin was associated with a sharp decline in active COVID-19 cases in Uttarakhand, India.

This article studies the effect of mass drug administration of ivermectin on the COVID-19 pandemic in the state of Uttarakhand, India. The study found that Uttarakhand had a sharp fall in the active cases by 3 to 4 weeks post lockdown, the period corresponding with maximum coverage of ivermectin distribution in the state, compared to four other states. Uttarakhand was also able to control the rising case fatality rate in state, by early decline in case growth rate and also partly due to decrease in severity of cases, as ivermectin is hypothesized to affect disease severity if given as early treatment. The study observed that mass drug administration of ivermectin had beneficial effect on the pandemic control in the state of Uttarakhand.

This study was observational, and it is not possible to say definitively that ivermectin was the cause of the observed effects. However, the study provides evidence that ivermectin may be an effective tool for controlling the COVID-19 pandemic.

Effect of Ivermectin mass drug administration on the COVID-19 Pandemic
Nidhi Uniyal, Hem Chandra Pandey, Ashutosh Sayana, Professor, Narayan Jeet, Professor, Anurag Agrawal, Professor, Sadhana Awasthi, Professor, Saurabh Agarwal, Puneet Kumar Gupta
International journal of health sciences, doi:10.53730/ijhs.v6ns1.4792
Uttarakhand, a hilly state of India adopted the strategy of mass drug administration of ivermectin during the second wave of COVID-19 pandemic as a measure to control the peak due to failing health infrastructure and health facility with sudden cases surge. This study was hereby planned with an aim of analyzing the effect of mass drug administration of ivermectin on the COVID-19 pandemic progression in the State of Uttarakhand. The trend of pandemic progression in five states of India was studied taking case growth rate, active case rate and case fatality rate as indicators. The percentage change in the indicators with the progression of pandemic was calculated for all five states and compared. The projected increased number of deaths, the state of Uttarakhand would have experienced, if the state had the declining average case growth of the other states taken for study was also calculated. The data analysis shows that the Uttarakhand had a sharp fall in the active cases by 3 to 4 weeks post lockdown, the period corresponding with maximum coverage of ivermectin distribution in the state, compared to four other states. Uttarakhand was also able to control the rising case fatality rate in state, by early decline in case growth rate and also partly due to decrease in severity of cases, as ivermectin is hypothesized to affect disease severity if given as early treatment. The study observed that mass drug administration of ivermectin had beneficial effect on the pandemic control in the state of Uttarakhand.
References
Arevalo, Pagotto, Pórfido, Daghero, Segovia et al., Ivermectin reduces in vivo coronavirus infection in a mouse experimental model, Scientific Reports
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral research, doi:10.1016/j.antiviral.2020.104787
Chaccour, Casellas, Blanco-Di Matteo, Pineda, Fernandez-Montero et al., The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial, EClinicalMedicine, doi:10.1016/j.eclinm.2020.100720
Hellwig, Maia, A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin, International journal of antimicrobial agents, doi:10.1016/j.ijantimicag.2020.106248
Meo, Abukhalaf, Alomar, Almutairi, Usmani et al., Impact of lockdown on COVID-19 prevalence and mortality during 2020 pandemic: observational analysis of 27 countries, European journal of medical research
Verity, Okell, Dorigatti, Winskill, Whittaker et al., Estimates of the severity of coronavirus disease 2019: a model-based analysis, The Lancet infectious diseases
Zaidi, Dehgani-Mobaraki, The mechanisms of action of ivermectin against SARS-CoV-2-an extensive review, The Journal of antibiotics
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