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0 0.5 1 1.5 2+ Improvement 32% Improvement Relative Risk Improvement (b) 34% c19ivm.org Huvemek et al. Ivermectin for COVID-19 RCT LATE TREATMENT Is late treatment with ivermectin beneficial for COVID-19? Double-blind RCT 100 patients in Bulgaria Greater improvement with ivermectin (not stat. sig., p=0.28) Huvemek Press Release Favors ivermectin Favors control
Kovid-19 - Huvemek® Phase 2 clinical trial
Huvemek Press Release (Preprint)
Huvemek, Kovid-19 - Huvemek® Phase 2 clinical trial, Press Release (Preprint)
Mar 2021   Source   PDF  
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Phase 2 results from a multicenter RCT of hospitalized patients in Bulgaria showing faster viral clearance, greater clinical improvement, and improved biomarkers with treatment. Ivermectin was taken on an empty stomach, potentially reducing lung tissue concentration by ~2.5x [twitter.com]. Limited data has been reported currently. No serious adverse events were observed. EudraCT 2020-002091-12.
risk of no improvement, 31.6% lower, RR 0.68, p = 0.28, treatment 13 of 50 (26.0%), control 19 of 50 (38.0%), NNT 8.3, day 7, patients with improvement on WHO scale.
risk of no improvement, 34.5% lower, RR 0.66, p = 0.07, treatment 19 of 50 (38.0%), control 29 of 50 (58.0%), NNT 5.0, day 4, patients with improvement on WHO scale.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huvemek et al., 25 Mar 2021, Double Blind Randomized Controlled Trial, Bulgaria, preprint, 1 author, average treatment delay 7.0 days, dosage 400μg/kg days 1-3.
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Late treatment
is less effective
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