Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects
MD Cynthia A Guzzo, BS Christine I Furtek, PhD Arturo G Porras, PhD Cong Chen, MS Robert Tipping, Coleen M Clineschmidt, Dr David G Sciberras, John Y‐k. Hsieh, MD Kenneth C Lasseter
The Journal of Clinical Pharmacology, doi:10.1177/009127002237994
I vermectin is a derivative of the avermectins, a family of macrocyclic lactones produced by the filamentous bacterium Streptomyces avermitilis. It is a highly effective antihelmintic agent used in animals and humans. Ivermectin was first approved for human use in 1987 and is donated by Merck & Co., Inc., as Mectizan ® for the treatment of onchocerciasis and, more recently, lymphatic filariasis in Africa and Latin America. More
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