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Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies

Wijaya et al., Cermin Dunia Kedokteran, 47:7
Dec 2020  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19ivm.org
Case report on 3 confirmed cases of COVID-19 with significant clinical and radiological improvement after a single dose of ivermectin.
Wijaya et al., 31 Dec 2020, peer-reviewed, 2 authors.
This PaperIvermectinAll
Ivermectin as a Potential Therapeutic Agent for COVID-19 -case studies
Natalia Sisca Wijaya, Sidharta Salim
In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) started in Wuhan, China, and has since become a global threat to human health. To date, the worldwide response to the COVID-19 outbreak has been limited mainly to monitoring/containment. Several types of drug, as well as vaccination, are still under investigation and clinical trials worldwide. Recently, a study demonstrated ~5000-fold reduction in SARS-CoV-2 virus at 48h in cell culture after a single treatment of ivermectin. A clinical study at the University of Utah found that the administration of ivermectin during COVID-19 illness in hospitalized patients is associated with lower mortality and hospital length of stay. We report three confirmed cases of COVID-19 infection with significant improvement clinically and radiologically, with following treatment single dose of ivermectin
References
Cally, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-COV-2 in vitro, Science Direct, doi:10.1016/j.antiviral.2020.104787
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of 2019 novel coronavirus infection in China, N Engl J Med, doi:10.1101/2020.02.06.20020974v1
Guzzo, Furtek, Porras, Chen, Tipping et al., Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects, J Clin Pharmacol
Jaroslaw, Gorovits, COVID-19 alert
Lundberg, Pinkham, Baer, Amaya, Narayanan et al., Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis virus replication, Antivir. Res
Patel, Desai, Grainger, Mehra, Usefulness of ivermectin in COVID-19 illness
Õmura, Crump, The life and times of ivermectin -a success story, Nat Rev Microbiol, doi:10.1038/nrmicro1048
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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