JURNAL TEKNOLOGI LABORATORIUM
Haruna Isiyaku Umar, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku, Lynda Chioma Ngozi-Olehi, Christian Ebere Enyoh, Chidi Edbert Duru
doi:10.29238/teknolabjournal.v11i1.344
The search for potential oral drugs either through synthetic routes or by drug repurposing for combating the dreaded covid-19 virus is still ongoing. The coronavirus spike glycoprotein and several other non-structural proteins play crucial roles in the replication and transmission of this virus. Recent research have identified ivermectin, nafamostat, and camostat as promising drug inhibitors of SARS-CoV-2 target proteins. The broad-spectrum inhibitory action of ivermectin, nafamostat, and camostat on the spike glycoprotein and some non-structural proteins of this virus was studied in silico. The spike glycoprotein, nsp3, nsp5, nsp9, nsp10, nsp13, and nsp16 were selected for this study and were
AUTHORS' CONTRIBUTIONS CED: Conceptualization, Data curation, Supervision, Methodology, Software HIU: Conceptualization, Supervision, Methodology, Data curation, Software. IAD: Visualization, Investigation. UEE: Visualization, Investigation. LCN: Original draft preparation, Writing-Reviewing and Editing. CEE: Original draft preparation, Writing-Reviewing and Editing.
FUNDING INFORMATION No funds, grants, or other support was received.
DATA AVAILABILITY STATEMENT All data generated or analyzed during this study are included in this published article.
DISCLOSURE STATEMENT The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors. The data is the result of the author's research and has never been published in other journals. The authors declare that they have no competing interests.
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