Conv. Plasma
Nigella Sativa

All ivermectin studies
Meta analysis
study COVID-19 treatment researchIvermectinIvermectin (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Utility of Ivermectin and Doxycycline combination for the treatment of SARSCoV-2

Spoorthi et al., IAIM, 2020, 7:10, 177-182
Nov 2020  
  Source   PDF   All Studies   Meta AnalysisMeta
Recovery time 21% Improvement Relative Risk Hospitalization time 16% Ivermectin  Spoorthi et al.  LATE TREATMENT Is late treatment with ivermectin + doxycycline beneficial for COVID-19? Prospective study of 100 patients in India Faster recovery (p=0.03) and shorter hospitalization (p=0.01) Spoorthi et al., IAIM, 2020, 177-182, Nov 2020 Favorsivermectin Favorscontrol 0 0.5 1 1.5 2+
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now with p < 0.00000000001 from 104 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
100 patient prospective trial of ivermectin + doxycycline showing reduced time to symptom resolution and shorter hospital stay with treatment.
This is the 19th of 104 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 1 sextillion).
51 studies are RCTs, which show efficacy with p=0.00000015.
recovery time, 21.1% lower, relative time 0.79, p = 0.03, treatment 50, control 50.
hospitalization time, 15.5% lower, relative time 0.84, p = 0.01, treatment 50, control 50.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Spoorthi et al., 14 Nov 2020, prospective, India, peer-reviewed, 2 authors, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with doxycycline) - results of individual treatments may vary.
This PaperIvermectinAll
Utility of Ivermectin and Doxycycline combination for the treatment of SARS-CoV-2
Veerapaneni Spoorthi, Surapaneni Sasank
Background: On March 11, 2020, the World Health Organization (WHO) officially declared coronavirus disease 2019 a global pandemic. Ivermectin and Doxycycline against SARSCoV-2 under in-vitro conditions showed beneficial results. However, large population studies with this combination are not elaborately studied, which was the aim of our study. Materials and Methods: A total of 122 patients admitted in a tertiary care centre, who tested positive for Reverse-transcriptase-polymerase-chain-reaction (RT-PCR) for SARS-CoV2 were included in the study and a total sample size of 100 patients was obtained after exclusion. 50 patients of the treatment group were treated with Ivermectin-Doxycycline combination. Results: The results had shown a significant reduction not only in mean duration of hospital (3.70 ± 2.27 days vs 4.69 ± 2.3 days), but also in complete resolution of symptoms stay (6.67 ± 2.01 days vs 4.69 ± 2.3 days). In a small subset of 10 patients RT-PCR for COVID was tested on 10 th day after the symptom onset in both the groups and there was no difference to be found. There was no significant difference in the side effect profile of either groups. Conclusion: Our study supports the benefits of utilization of combination of Doxycycline and Ivermectin in mild to moderate COVID-19 infection in terms of early recovery based on the time for symptom resolution and the mean duration of hospital stay.
Caly, Druce, Catton, Jans, Wagstaff, The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro, Antiviral Res
Chowdhury, Shahbaz, Karim, Islam, Dan et al., A comparative observational study on Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients, J. Clin Med Research
Conforti, Giuffrida, Zalaudek, Meo, Doxycycline, a widely used antibiotic in dermatology with a possible anti-inflammatory action against IL-6 in COVID-19 outbreak
Mccarthy, Laukas, Hotez, Chemotherapy of Helminth infections (Chapter 51
Patel, Desai, Grainger, Mehra, Usefulness of Ivermectin in COVID-19 Illness
Taiub, Chowdhury, Shahbaz, Karim, A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients,
Ullah, Abdullah, Roomi, Safety and Efficacy of Hydroxychloroquine in COVID-19: A Systematic Review and Meta-Analysis, Journal of clinical medical research
Vora, Arora, Behera, Tripathy, White paper on Ivermectin as a potential therapy for COVID-19, Indian J Tuberc
Wang, Hu, Hu, Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirusinfected pneumonia in Wuhan, China, JAMA
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop