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0 0.5 1 1.5 2+ Recovery time from enr.. 16% Improvement Relative Risk c19ivm.org Podder et al. Ivermectin for COVID-19 RCT LATE TREATMENT Is late treatment with ivermectin beneficial for COVID-19? RCT 62 patients in Bangladesh Faster recovery with ivermectin (not stat. sig., p=0.34) Podder et al., IMC J. Med. Science, 14:2, July 2020 Favors ivermectin Favors control
Outcome of ivermectin treated mild to moderate COVID-19 cases: a single-centre, open-label, randomised controlled study
Podder et al., IMC J. Med. Science, 14:2, July 2020
Podder et al., Outcome of ivermectin treated mild to moderate COVID-19 cases: a single-centre, open-label, randomised.., IMC J. Med. Science, 14:2, July 2020
Sep 2020   Source   PDF  
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Small RCT with 32 ivermectin patients and 30 control patients. The mean recovery time after enrolment in the intervention arm was 5.31 ± 2.48 days vs. 6.33 ± 4.23 days in the control arm, p > 0.05. Negative PCR results were not significantly different between control and intervention arms, p>0.05. We are not sure what the results were because the abstract and Table 5 have switched the results.
recovery time from enrollment, 16.1% lower, relative time 0.84, p = 0.34, treatment 32, control 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Podder et al., 3 Sep 2020, Randomized Controlled Trial, Bangladesh, peer-reviewed, 4 authors, average treatment delay 7.0 days, dosage 200μg/kg single dose.
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Abstract: Original Article OPEN ACCESS Outcome of ivermectin treated mild to moderate COVID-19 cases: a single-centre, open-label, randomised controlled study 1 1 1 Chinmay Saha Podder , Nandini Chowdhury , Mohim Ibne Sina , Wasim Md Mohosin Ul Haque 1 2* 2 Debidwar Upazila Health Complex, Debidwar, Comilla, Bangladesh; Department of Nephrology, BIRDEM General Hospital, Dhaka, Bangladesh Abstract Background and objectives: Various existing non-antiviral drugs are being used to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based mostly on existing data from previous coronavirus outbreaks. Ivermectin is one of such agents being widely used to treat early-stage of COVID-19. This study evaluated the outcome of ivermectin treated mild to moderate COVID-19 cases compared to usual care. Methods: This open-label randomised controlled study was conducted at a sub-district (Upazila) health complex from 1st May 2020 to the end of July 2020. Consecutive RT-PCR positive eligible COVID-19 patients were randomised into control and intervention arms. In the intervention arm, ivermectin 200 micrograms/kg single dose was administered orally in addition to usual care and was followed up till recovery. Repeat RT-PCR was done on day ten since the first positive result. The end point with regard to treatment outcome was time required for the resolution of symptoms from the onset of the symptoms and following enrollement in the study. Results: A total of 62 mild to moderate COVID-19 patients were enrolled in the study. There were 30 patients in the control arm and 32 patients in the intervention arm. Total recovery time from the onset of symptoms to complete resolution of symptoms of the patients in the intervention arm was 10.09 ± 3.236 days, compared to 11.50 ± 5.32 days in the control arm (95% CI -0.860,3.627, p>. 05) and was not significantly different. The mean recovery time after enrolment in the intervention arm was 5.31 ± 2.48 days, which also did not differ significantly from the control arm of 6.33 ± 4.23 days (95% CI – 0.766, 2.808, p> 0.05). Results of negative repeat RT- PCR were not significantly different between control and intervention arms (control 90% vs intervention 95%, p>.05). Conclusion: Ivermectin had no beneficial effect on the disease course over usual care in mild to moderate COVID-19 cases. IMC J Med Sci 2020; 14(2): 002. EPub date: 03 September 2020
Late treatment
is less effective
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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