Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19 Positive Patients in Index Medical College Hospital and Research Center, Indore, India
Mourya et al., Int. J. Health and Clinical Research
Mourya et al., Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19 Positive Patients in.., Int. J. Health and Clinical Research
Retrospective 100 patients in India with 50 treated with ivermectin, and SOC for all patients including HCQ+AZ, showing much higher viral clearance with ivermectin. Baseline clinical status was worse in the control group. Time of testing after treatment initiation was longer in the control group (mean 7.24 days versus 5.22 days).
Abstract: International Journal of Health and Clinical Research, 2021;4(6):265-267
e-ISSN: 2590-3241, p-ISSN: 2590-325X
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Original Research Article
Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19
Positive Patients in Index Medical College Hospital and Research Center, Indore, India
Sudhir Mourya1, Ajay Singh Thakur2, Deepti Singh Hada3*, Vibhu Sagar Kulshreshtha4, Yash
Sharma5
1
Professor and Head, Department of Internal Medicine, Index Medical College Hospital and Research Center,
Indore, Madhya Pradesh, India
2
Associate Professor, Department of Orthopedics, Index Medical College Hospital and Research Center, Indore,
Madhya Pradesh, India
3
Assistant Dean and Assistant Professor, Department of Oral Medicine and Radiology, Index Institute of Dental
Sciences, Indore, Madhya Pradesh, India
4
PG Resident, Department of Internal Medicine, Index Medical College Hospital and Research Center, Indore,
Madhya Pradesh, India
5
PG Resident, Department of Orthopedics, Index Medical College Hospital and Research Center, Indore,
Madhya Pradesh, India
Received: 12-01-2021 / Revised: 13-03-2021 / Accepted:27-03-2021
Abstract
Background: SARS-CoV-2 is a novel virus that first emerged in Wuhan, China. Considering the novel nature of the coronavirus, there are not
yet any proven treatment strategies. In this emergency, there is no specific pharmacologic treatment that specifically targets and kill the virus or
control the infection and improve the clinical outcomes. Several drugs were repurposed for this illness based on in-vitro studies or minimal
evidence to combat the rapid spread of the COVID-19 pandemic.Aims and objectives: To compare efficacy of two regimens’, Regimen 1
(hydroxychloroquine and azithromycin) and Regimen 2 (hydroxychloroquine, azithromycin and ivermectin) in Covid-19 positive patients.
Materials and methods: An observation study on 100 Covid 19 positive patients having age between 20-60 years of either sex was conducted
from April to May 2020. Patients below 20 years of and above 60 years of age and having chronic conditions like hypertension, diabetes and
others were excluded. Group 1 received oral hydroxychloroquine 400 mg twice a day with azithromycin 500 mg once a day. Both medications
were given by per oral route for a period of 7 days. Group 2 received hydroxychloroquine 400 mg twice a day with azithromycin 500 mg once a
day and ivermectin 12 mg once a day. All medications were given by per oral route for a period of 7 days.Results: Mean age of patients in
Group 1 and Group 2 was 37.62 ± 11.609 years and 38.20±11.73 years respectively (p=0.804). No significant difference was obtained between
the SpO2 concentration (p=0.778). When we did final the COVID-19 testing, it showed that majority of the patients were found negative in the
group 2, whereas 94% were found to be positive in the group 1. This difference was statistically significant with the p value of <0.001.
Conclusion: The treatment with HCQ, azithromycin, and ivermectin had a better success rate compared to HCQ and azithromycin. Based on the
results, ivermectin could be the potential therapeutic agents for the COVID-19 disease. The study had various limitations; so further randomized
controlled trial is required for the results to be implemented on the larger population.
Keywords: HCQ, azithromycin,..
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