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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Viral clearance 89% primary Improvement Relative Risk Ivermectin  Mourya et al.  EARLY TREATMENT Is early treatment with ivermectin beneficial for COVID-19? Retrospective 100 patients in India Improved viral clearance with ivermectin (p<0.000001) Mourya et al., Int. J. Health and Clin.., Apr 2021 Favors ivermectin Favors control

Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19 Positive Patients in Index Medical College Hospital and Research Center, Indore, India

Mourya et al., Int. J. Health and Clinical Research
Apr 2021  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 102 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 100 patients in India with 50 treated with ivermectin, and SOC for all patients including HCQ+AZ, showing much higher viral clearance with ivermectin. Baseline clinical status was worse in the control group. Time of testing after treatment initiation was longer in the control group (mean 7.24 days versus 5.22 days).
This is the 47th of 102 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 560 quintillion).
49 studies are RCTs, which show efficacy with p=0.00000038.
risk of no viral clearance, 89.4% lower, RR 0.11, p < 0.001, treatment 5 of 50 (10.0%), control 47 of 50 (94.0%), NNT 1.2, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mourya et al., 1 Apr 2021, retrospective, India, peer-reviewed, 5 authors, dosage 12mg days 1-7.
This PaperIvermectinAll
Comparative Analytical Study of Two Different Drug Regimens in Treatment of Covid 19 Positive Patients in Index Medical College Hospital and Research Center, Indore, India
Sudhir Mourya, Ajay Singh Thakur, Deepti Singh Hada, Vibhu Sagar Kulshreshtha, Yash Sharma
Background: SARS-CoV-2 is a novel virus that first emerged in Wuhan, China. Considering the novel nature of the coronavirus, there are not yet any proven treatment strategies. In this emergency, there is no specific pharmacologic treatment that specifically targets and kill the virus or control the infection and improve the clinical outcomes. Several drugs were repurposed for this illness based on in-vitro studies or minimal evidence to combat the rapid spread of the COVID-19 pandemic.Aims and objectives: To compare efficacy of two regimens', Regimen 1 (hydroxychloroquine and azithromycin) and Regimen 2 (hydroxychloroquine, azithromycin and ivermectin) in Covid-19 positive patients. Materials and methods: An observation study on 100 Covid 19 positive patients having age between 20-60 years of either sex was conducted from April to May 2020. Patients below 20 years of and above 60 years of age and having chronic conditions like hypertension, diabetes and others were excluded. Group 1 received oral hydroxychloroquine 400 mg twice a day with azithromycin 500 mg once a day. Both medications were given by per oral route for a period of 7 days. Group 2 received hydroxychloroquine 400 mg twice a day with azithromycin 500 mg once a day and ivermectin 12 mg once a day. All medications were given by per oral route for a period of 7 days.Results: Mean age of patients in Group 1 and Group 2 was 37.62 ± 11.609 years and 38.20±11.73 years respectively (p=0.804). No significant difference was obtained between the SpO2 concentration (p=0.778). When we did final the COVID-19 testing, it showed that majority of the patients were found negative in the group 2, whereas 94% were found to be positive in the group 1. This difference was statistically significant with the p value of <0.001. Conclusion: The treatment with HCQ, azithromycin, and ivermectin had a better success rate compared to HCQ and azithromycin. Based on the results, ivermectin could be the potential therapeutic agents for the COVID-19 disease. The study had various limitations; so further randomized controlled trial is required for the results to be implemented on the larger population.
Conflict of Interest: Nil Source of support:Nil
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Gorial, Mashhadani, Sayaly, Dakhil, Mashhadani et al., Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management, Pilot Trial
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