Randomized trials - Ivermectin repurposing for COVID-19 treatment of outpatients with mild disease in primary health care centers

{ 'indexed': {'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T12:15:58Z', 'timestamp': 1656072958816}, 'reference-count': 0, 'publisher': 'Research, Society and Development', 'issue': '8', 'license': [ { 'start': { 'date-parts': [[2022, 6, 21]], 'date-time': '2022-06-21T00:00:00Z', 'timestamp': 1655769600000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Objective: to evaluate the therapeutic intervention with Ivermectin in outpatients ' 'with COVID-19 mild disease, to increase medical discharge and prevent the progression to ' 'moderate or severe disease. Methods: Randomized Trial, n= 254. The subjects were divided into ' 'experimental (EG: n= 110) and control groups (CG: n= 144). The EG received Ivermectin orally ' '0.6 mg/kg weight in two doses. All participants were by physical examination COVID-19 ' 'diagnosed with negative RT-PCR at the beginning and the end of protocol. Differences between ' 'the variables were determined using the Chi-square test (p&lt;0.05). The contagion risk (Odds ' 'Ratio) was calculated using software STATA. Results: Both groups were similar in age, sex, ' 'and comorbidities. A significant reduction in the percentage of participants with symptoms ' '(PPS) was observed in the EG and CG when the clinical evaluation of symptoms was performed ' 'from 5th to 9th day (p= 0.0005). When the clinical evaluation was performed from 10th to 14th ' 'day there was no significant difference. A higher proportion of medical discharge was ' 'observed in EG (98.2%) vs. CG (86.1%) (p= 0.0007). EG showed 8 times more chance of receiving ' 'medical discharge than CG (OR 8.71, 95% CI: 1·99 – 38.12, p= 0.004). The treatment effect ' 'with Ivermectin to obtain medical discharge from outpatient care was analyzed by logistic ' 'regression. Then, the chance to obtain medical discharge was independent of variables sex, ' 'age, and comorbidities. Conclusion: This work supports the potential efficacy of Ivermectin ' 'in outpatient care with mild COVID-19 as a potentially useful intervention of public health ' 'consideration.</jats:p>', 'DOI': '10.33448/rsd-v11i8.30844', 'type': 'journal-article', 'created': {'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T11:54:03Z', 'timestamp': 1656071643000}, 'page': 'e35511830844', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Randomized trials - Ivermectin repurposing for COVID-19 treatment of outpatients with mild ' 'disease in primary health care centers', 'prefix': '10.33448', 'volume': '11', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-3016-612X', 'authenticated-orcid': False, 'given': 'Rossana Elena', 'family': 'Chahla', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-2014-1666', 'authenticated-orcid': False, 'given': 'Luis Medina', 'family': 'Ruiz', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-9838-5559', 'authenticated-orcid': False, 'given': 'Teresa', 'family': 'Mena', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-4071-4927', 'authenticated-orcid': False, 'given': 'Yolanda', 'family': 'Brepe', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-0370-3599', 'authenticated-orcid': False, 'given': 'Paola', 'family': 'Terranova', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8339-1160', 'authenticated-orcid': False, 'given': 'Eugenia Silvana', 'family': 'Ortega', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-5781-8327', 'authenticated-orcid': False, 'given': 'Guillermo Gabriel', 'family': 'Barrenechea', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-5454-9873', 'authenticated-orcid': False, 'given': 'Daniel Gustavo', 'family': 'Goroso', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0632-9427', 'authenticated-orcid': False, 'given': 'María de los Ángeles', 'family': 'Peral de Bruno', 'sequence': 'additional', 'affiliation': []}], 'member': '19099', 'published-online': {'date-parts': [[2022, 6, 21]]}, 'container-title': 'Research, Society and Development', 'original-title': [], 'link': [ { 'URL': 'https://rsdjournal.org/index.php/rsd/article/download/30844/26582', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://rsdjournal.org/index.php/rsd/article/download/30844/26582', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 6, 24]], 'date-time': '2022-06-24T11:54:03Z', 'timestamp': 1656071643000}, 'score': 1, 'resource': {'primary': {'URL': 'https://rsdjournal.org/index.php/rsd/article/view/30844'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 6, 21]]}, 'references-count': 0, 'journal-issue': {'issue': '8', 'published-online': {'date-parts': [[2022, 6, 6]]}}, 'URL': 'http://dx.doi.org/10.33448/rsd-v11i8.30844', 'relation': {}, 'ISSN': ['2525-3409'], 'container-title-short': 'RSD', 'published': {'date-parts': [[2022, 6, 21]]}}