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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 92% Improvement Relative Risk Hospitalization 93% primary c19ivm.org Borody et al. Ivermectin for COVID-19 EARLY TREATMENT Favors ivermectin Favors control
Combination Therapy For COVID-19 Based on Ivermectin in an Australian Population
Borody et al., TrialSite News (Preprint)
19 Oct 2021    Source   PDF   Share   Tweet
Retrospective 600 PCR+ outpatients in Australia treated with ivermectin, zinc, and doxycycline, showing significantly lower mortality and hospitalization with treatment. This trial uses a synthetic control group, and the preliminary report provides minimal details.
For discussion of the use of a synthetic control group, see [doyourownresearch.substack.com]. Notably, advantages include less-biased recruitment (patients do not opt-out if they feel they need treatment and don't want to risk placebo), trials are cheaper, there is less delay in treatment, and trials can be run where it is not ethical to give patients placebo.
risk of death, 92.3% lower, RR 0.08, p = 0.03, treatment 0 of 600 (0.0%), control 6 of 600 (1.0%), NNT 100, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 92.9% lower, RR 0.07, p < 0.001, treatment 5 of 600 (0.8%), control 70 of 600 (11.7%), NNT 9.2, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: preliminary report with minimal details.
Borody et al., 19 Oct 2021, retrospective, Australia, preprint, 2 authors, study period 1 June, 2021 - 30 September, 2021, dosage 24mg days 1-10, this trial uses multiple treatments in the treatment arm (combined with zinc and doxycycline) - results of individual treatments may vary.
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