Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers
et al., Cureus 13:8, doi:10.7759/cureus.16897 (date from earlier preprint)
, Prophylactic Role of Ivermectin in Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare.., Cureus 13:8, doi:10.7759/cureus.16897 (date from earlier preprint)
Prospective prophylaxis study with 3,532 healthcare workers, 2,199 receiving two-dose ivermectin prophylaxis, showing adjusted relative risk of confirmed COVID-19 with treatment 0.17 [0.12-0.23] p<0.001. 186 patients took only the first dose, and no significant difference was observed for this group. The same group published an earlier small study with 117 ivermectin patients. There were no serious adverse events. T/IM-NF/CM&FM/20/142.
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risk of case, 83.0% lower, RR 0.17, p < 0.001, treatment 45 of 2,199 (2.0%), control 133 of 1,147 (11.6%), NNT 10, two doses, primary outcome.
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risk of case, 4.0% higher, RR 1.04, p = 0.85, treatment 23 of 186 (12.4%), control 133 of 1,147 (11.6%), patients only receiving the first dose.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Behera et al., 15 Feb 2021, prospective, India, peer-reviewed, 14 authors, dosage 300μg/kg days 1, 4.
Abstract: Open Access Original
Article
DOI: 10.7759/cureus.16897
Prophylactic Role of Ivermectin in Severe Acute
Respiratory Syndrome Coronavirus 2 Infection
Among Healthcare Workers
Priyamadhaba Behera 1 , Binod K. Patro 1 , Biswa M. Padhy 2 , Prasanta R. Mohapatra 3 , Shakti K. Bal 3 ,
Pradnya D. Chandanshive 1 , Rashmi R. Mohanty 4 , SR Ravikumar 1 , Arvind Singh 1 , Sudipta R. Singh 5 ,
Siva Santosh Kumar Pentapati 1 , Jyolsna Nair 1 , Gitanjali Batmanbane 6
1. Community Medicine and Family Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, IND
2. Pharmacology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, IND 3. Pulmonary Medicine and
Critical Care, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, IND 4. General Medicine, All India
Institute of Medical Sciences Bhubaneswar, Bhubaneswar, IND 5. Forensic Medicine, All India Institute of Medical
Sciences Bhubaneswar, Bhubaneswar, IND 6. Medicine, All India Institute of Medical Sciences Bhubaneswar,
Bhubaneswar, IND
Corresponding author: Gitanjali Batmanbane, director@aiimsbhubaneswar.edu.in
Abstract
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