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Ivermectin is associated with increase in SPO2 in hypoxemic SARS-CoV-2 patients: pharmacodynamic profile and correlates

Babalola et al., Research Square, doi:10.21203/
Apr 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 103 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Extended analysis of Thairu, showing significantly faster and greater improvement in SpO2 with ivermectin treatment.
Babalola et al., 27 Apr 2022, preprint, 6 authors.
This PaperIvermectinAll
Ivermectin is associated with increase in SPO2 in hypoxemic SARS-Cov-2 patients: pharmacodynamic profile and correlates.
Olufemi Emmanuel Babalola, Adesuyi A Ajayi, Thairu Yunusa, Yahaya Ndanusa, John O Ogedengbe, Omede Ogu
Background and Objectives: Hypoxemic respiratory failure is a common mode of demise in Covid 19 disease. We aimed to describe the time course of SPO2 changes in Covid 19 patients treated with and without ivermectin. Methods: This was a parallel group, prospective comparative study of propensity matched Covid 19 patients (Cycle threshold Ct < 25, SPO2 < 94%). 21 of the patients received Ivermectin (IVM) inclusive regime at 12 mg daily for 5 days, while 26 others received Non-ivermectin inclusive regime ( NIVM). Results: the IVM group demonstrated earlier and greater increase in SPO2 (p=0.000) which paralleled greater and faster virological clearance (p = 0.000) on Repeat measures Analysis of Variance RMANOVA. There was a signi cant correlation between absolute SPO2 and absolute Ct on day 5 (r = 0.77 ) and day 7 (r = 0.77) both p = 0.000. Incremental SPO2 also correlated with incremental Ct. by day 5
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