Ivermectin is associated with increase in SPO2 in hypoxemic SARS-CoV-2 patients: pharmacodynamic profile and correlates
Babalola et al.
, Ivermectin is associated with increase in SPO2 in hypoxemic SARS-CoV-2 patients: pharmacodynamic profile and..
, Research Square, doi:10.21203/rs.3.rs-1576399/v1 (Preprint)
Extended analysis of [Thairu]
, showing significantly faster and greater improvement in SpO2
with ivermectin treatment.
Babalola et al., 27 Apr 2022, preprint, 6 authors.
Abstract: Ivermectin is associated with increase in SPO2 in
hypoxemic SARS-Cov-2 patients: pharmacodynamic
profile and correlates.
olufemi Emmanuel Babalola ( email@example.com )
Bingham University, New Karu https://orcid.org/0000-0001-7737-3831
Adesuyi A. Ajayi
Baylor College, Texas https://orcid.org/0000-0003-2036-7929
University of Abuja https://orcid.org/0000-0003-1941-8151
Al Ummah Foundation, Abuja
John O. Ogedengbe
University of Abuja https://orcid.org/0000-0002-1559-1750
Federal Ministry of Health, Abuja https://orcid.org/0000-0001-6695-1405
Keywords: Ivermectin, arterial oxygen saturation, covid-19, viral load
Posted Date: April 27th, 2022
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
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Background and Objectives: Hypoxemic respiratory failure is a common mode of demise in Covid 19
disease. We aimed to describe the time course of SPO2 changes in Covid 19 patients treated with and
Methods: This was a parallel group, prospective comparative study of propensity matched Covid 19
patients (Cycle threshold Ct < 25, SPO2 < 94%). 21 of the patients received Ivermectin (IVM) inclusive
regime at 12 mg daily for 5 days, while 26 others received Non-ivermectin inclusive regime ( NIVM).
Results: the IVM group demonstrated earlier and greater increase in SPO2 (p=0.000) which paralleled
greater and faster virological clearance (p = 0.000) on Repeat measures Analysis of Variance
RMANOVA. There was a significant correlation between absolute SPO2 and absolute Ct on day 5 (r =
0.77 ) and day 7 (r = 0.77) both p = 0.000. Incremental SPO2 also correlated with incremental Ct. by day 5
( r = 0.397, p = 0.003) and day 7 ( r = 0.315 , p = 0.0002) relative to baseline. Increase in platelet count
correlated with increased SPO2 (r = 0.252, p = 0.029) on IVM, but negatively with NIVM (r = - 0.28, p = 0
.17). Inflammatory markers such as ESR, CRP or D- dimer showed no significant correlation with SPO2.
Increase in SPO2 on IVM was magnified in males.
Conclusion: IVM regime appears to be associated with faster and greater increase in SPO2 paralleling
faster viral clearance in Covid 19 patients.
is less effective
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