Abstract: COVID-19 Mortality and Ivermectin https://doi.org/10.29309/TPMJ/2022.29.09.6634 The Professional Medical Journal www.theprofesional.com 2022, Volume, 29 Issue, 09 ORIGINAL ARTICLE Does ivermectin reduce COVID-19 mortality and progression of disease severity? – A retrospective study. Tehseen Akhtar1, Amber Hanif2, Pyar Ali3, Muhammad Hussain Haroon4, Nimra Akram5, Muhammad Umar Raza6, Khalid Imran7, Nimra Shakeel8, Ramsha Shakeel9 Article Citation: Akhtar T, Hanif A, Ali P, Haroon MH, Akram N, Raza MU, Shakeel N, Shakeel R. Does ivermectin reduce COVID-19 mortality and progression of disease severity? – A retrospective study. Professional Med J 2022; 29(9):1384-1391. https://doi.org/10.29309/TPMJ/2022.29.09.6634 ABSTRACT… Objective: To investigate the efficacy of ivermectin in the treatment of mild, moderate, and severe COVID-19 infection. Study Design: Retrospective Cohort study. Setting: COVID-19 Treatment Centre, Dr. Ruth K M Pfau Civil Hospital Karachi. Period: July 2020 to December 2020. Material & Methods: Medical records of 423 patients during a selected duration of 6 months were reviewed. Patients were stratified into two groups based on whether or not they received a 6-day course of ivermectin in addition to the standard treatment for COVID-19. Primary outcome measures were rate of mortality, days from the start of treatment to negative SARS-CoV-2 PCR, and rate of step-up to the intensive care unit. Results: Patients who received ivermectin required a lesser number of days (8.39 days ± 2.04) to become COVID negative than the patients who didn’t receive ivermectin (20.38 days ± 6.32), (p < 0.001). Multinomial logistic regression showed that the patients who were given ivermectin for COVID 19 infection were four times more likely to be discharged home than stepping up to ICU. The ICU step-up rate in the ivermectin group was found to be 3.7% compared to 13.04% in the non-ivermectin group. No significant differences in mortality were found. Conclusion: Treatment with ivermectin in COVID-19 infection is associated with improved outcomes in terms of reduction in duration of illness as well as the progression of disease severity. Key words: Ivermectin, COVID-19, SARS-CoV-2, Mortality.