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Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis

Zein et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395
Jan 2022  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19early.org
Systematic review and meta analysis showing that colchicine was associated with lower mortality in COVID-19 patients:
All studies: RR 0.66 [95%CI 0.53, 0.83], p < 0.001; I2: 42%
RCTs: RR 0.81 [95%CI 0.54, 1.20], p = 0.29; I2: 10%
The RCT result is non-significant, but is highly affected by the very late stage RECOVERY trial, which is not generalizable to earlier usage.
10 meta analyses show significant improvements with colchicine for mortality1-8, oxygen therapy8, hospitalization9, and severity10.
Currently there are 56 colchicine for COVID-19 studies, showing 28% lower mortality [17‑37%], 29% lower ventilation [-15‑56%], 34% lower ICU admission [8‑52%], 19% lower hospitalization [11‑26%], and 9% more cases [-8‑29%].
Zein et al., 12 Jan 2022, peer-reviewed, 2 authors.
This PaperColchicineAll
Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis
Ahmad Fariz Malvi Zamzam Zein, MD Wilson Matthew Raffaello
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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