Repurposing Drugs for Covid-19 by a Developing Country
Valerio Pascua et al.,
Repurposing Drugs for Covid-19 by a Developing Country,
Epidemiology International Journal, doi:10.23880/eij-16000234
Review of a multiphasic multidrug early treatment protocol for COVID-19 in Honduras, showing one death from 415 patients, which was for a patient not receiving early treatment (presenting on the 5th day in need of hospitalization and supplemental oxygen). Treatment included ivermectin, aspirin, colchicine, fluvoxamine, and famotidine.
Valerio Pascua et al., 20 May 2022, Honduras, peer-reviewed, 31 authors, study period November 2020 - October 2021.
Abstract: Epidemiology International Journal
ISSN: 2639-2038
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Repurposing Drugs for Covid-19 by a Developing Country
Valerio Pascua F1, Baires F2, Diaz O3, Sierra M4, Palou E5, Alvarado T6,
Hernández CI7, Lewis AS8, Durón M9, Valenzuela HD10, Flores A10, Alvarenga
LF11, Diaz T12, Chajtur DG13, Benítez LG14, Pineda E15, Vargas M16, Caraccioli
GG16, Garay J16, Godoy J16, Matamoros D16, Larios J17, Lara R15, Deras P18,
Leon V15, Videa EO19, Stevens ML20, Eberhard D20, Singh J21, Sekhon AK22*
and Sierra Hoffman M23
Research Article
Volume 6 Issue 2
Received Date: April 26, 2022
Published Date: May 20, 2022
DOI: 10.23880/eij-16000234
Department of Critical Care, Hospital CEMESA, Honduras
Universidad Nacional Autónoma de Honduras, Honduras
3
Department of Critical Care Hospital Regional del Norte Instituto Hondureño de Seguridad Social, Honduras
4
Universidad Tecnologica Centroamericana, Honduras
5
Internal Medicine Department, Universidad Nacional Autónoma de Honduras, Honduras
6
Internal Medicien Depatment, Universidad Nacional Autónoma de Honduras, Honduras
7
HEME Clinic, Honduras
8
Pharmacy Department, El Campo Memorial Hospital, United States of America
9
Laboratorios Durón, Honduras
10
Emergency Department, Hospital Roberto Suazo Córdova, Honduras
11
Universidad Nacional Autónoma de Honduras, Honduras
12
La Paz Regional Health Department, Honduras
13
Universidad Católica de Honduras, Honduras
14
Universidad Nacional Autónoma de Honduras, Honduras
15
Emergency Department, Hospital CEMESA, Honduras
16
Emergency Department, Hospital Leonardo Martinez, Honduras
17
Emergency Department, Hospital Santa Bárbara Integrado, Honduras
18
Centro de Investigation de DEMEDICA, Honduras
19
Clinical de Attention Medical Integral CAMI, Honduras
20
Research Department, Texas A&M College of Medicine, United States of America
21
Cardiovascular Medicine, University of California, United States of America
22
Sleep Medicine, United States of America
23
Research and Infectious Disease Department, Texas A&M College of Medicine, United States of America
1
2
*Corresponding author: Anupamjeet Kaur Sekhon, Sleep Medicine, Kaiser Permanente, 9961 Sierra Avenue, #7, Fontana, CA,
USA, Tel: 832-983-1131; Email: anupamsekhon@yahoo.com
Abstract
Background: Early treatment of COVID-19 disease with repurposed drugs has been controversial. Most guidelines in the
developed world recommend monoclonal antibodies or Ritonavir/Nirmatrelvir therapies for patients at risk of clinical
deterioration, but accessibility to these in developing countries is a big challenge. The primary purpose of this study is to
Repurposing Drugs for Covid-19 by a Developing Country
Epidemol Int J
2
Epidemiology International Journal
review the impact of early treatment of COVID-19 with repurposed drugs on hospitalizations, oxygen requirement, and
mortality in a limited resource setting.
Methods: This observational cohort study was Institutional Review Board (IRB) approved. Data was collected from medical
records from November 2020 until October 2021. A multiphasic multidrug protocol of repurposed drugs was used as
COVID-19 outpatient therapy in Honduras. Patients within 7 days of disease onset and mild symptoms received Ivermectin,
Aspirin, Colchicine, Fluvoxamine, and Famotidine. On day 7, patients received Prednisolone and Apixaban if CT-chest showed
pulmonary infiltrates and inflammatory markers were elevated. Patients were followed..
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