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Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients

Sobrinho et al., Medicina Clínica Práctica, doi:10.1016/j.mcpsp.2022.100346
Sep 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
*, now known with p < 0.00000000001 from 100 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 116 patients between May and September 2020 in Brazil receiving an early treatment protocol including ivermectin and azithromycin, showing no mortality compared to up to 5.7% CFR in Brazil during the study period.
Sobrinho et al., 22 Sep 2022, Brazil, peer-reviewed, mean age 48.0, 4 authors, study period May 2020 - September 2020.
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Clinical protocol for early treatment of COVID-19 in a real-world scenario: Results of a series of patients
Silvestre Sobrinho, Fabiana Perrone, Guilherme Montal, Aroldo Bacellar
Medicina Clínica Práctica, doi:10.1016/j.mcpsp.2022.100346
Introduction: Despite the advance in vaccination, the SARS-CoV-2 infection remains a challenge for the medical community. Outpatient and hospital therapy for COVID-19 are still improving. Our study aimed to report the results of a series of patients with COVID-19 who participated in an outpatient treatment protocol since the first clinical manifestation. Methods: A case series report of individuals aged ≥18 years with clinical symptoms and a confirmed test for COVID-19 submitted to a treatment protocol. Patients were enrolled between May and September 2020 and followed for at least 15 days. The assessed clinical outcomes were the need for hospitalization, admission to the intensive care unit, orotracheal intubation, and death. Results: We studied a 116 patients. The mean age was 48 ± 14 years. Females formed 53%. The main comorbidities wereobesity (15.5%), systemic arterial hypertension (10.3%) ,type II diabetes (6%), and lung diseases (6.0%). Temperature N 37.7 °C (51.7%), cough (55.2%), myalgia (37.1%), headache (37.9%), and fatigue (34.5%) were the most frequent signs and symptoms. According to different disease staging, the most administered drugs were: azithromycin, ivermectin, corticosteroid, antibiotics, and anticoagulants. There was no death, and hospitalization accounted for only 8.6% of the patients (1 in ICU); none required orotracheal intubation. The mean length of hospital stay was 5.8 days.
Author's contribution S.S. conceived the study idea, designed the methods, examined, and treated patients, collected data, and drafted the manuscript; F.P. collected data and cared for patients; G.M. performed the thorax imaging review end reviewed the manuscript. A.B. performed patient neurological reviews, drafted the manuscript, and executed English editing; All authors read, discussed, and approved the final manuscript. Competitive interests There is no conflict of interest. Financing
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