Abstract: Journal of Cardiovascular Disease Research ISSN:0975-3583,0976-2833 VOL12,ISSUE05,2021 Original Article Clinical Effect of the Combination Therapy of Hydroxychloroquine, Azithromycin and Ivermectin in Patients with COVID-19 SatyanandSathi1, Anil Kumar Garg 1, Amit Mittal2, Savita Verma* 4, Virendra Singh Saini1, Manoj Kumar Singh1, Devinder Vohra 1 , Sushil Kumar 3 1 Department of Medicine, S.M.M.H. Government Medical College Saharanpur, Uttar Pradesh, India Department of Community Medicine, S.M.M.H. Government Medical College Saharanpur, Uttar Pradesh, India 3 Department of Paediatrics,S.M.M.H. Government Medical College Saharanpur, Uttar Pradesh, India 4 M.S. Obstetrics and Gynaecology, S.M.M.H. Government Medical College Saharanpur, Uttar Pradesh, India *Corresponding author: Dr. Savita Verma, Assistant Professor, M.S. Obstetrics and Gynaecology, S.M.M.H. Government Medical College, Ambala Road, Saharanpur, Uttar Pradesh, India, Email : Savita.sathi@gmail.com 2 Abstract Background: The ongoing pandemic has highlighted the need for an effective treatment of COVID-19 patients and prevention of SARS-CoV-2 community transmission.Methods: We conducted a prospective observational study on a cohort of 85 COVID-19 patients (80% males, median age 46 years, range 18–80 years). Patients were treated with a triple drug therapy: ivermectin 12 mg once a week, hydroxychloroquine 400 mg twice a day on the first day and 200 mg twice a day for the next 4 days, and azithromycin 500 mg once a day for 5 days. Endpoints were assessed by clinical outcomes, death, negative SARS-CoV-2 RNA-PCR test on the tenth day, and length of the hospital stay.Results: All patients improved except one 70-year-old female, who died on the third day of admission. The clinical outcome was considered good as 95.24% (80/84) of patients presented a negative SARS-CoV-2 RNA-PCR test on the tenth day of admission and 90.48% (76/84) were discharged in stable condition.Conclusions: The response must focus on immediate isolation of COVID-19 patients and their early treatment to prevent irreversible severe respiratory injury. Our study shows the beneficial effect of triple drug therapy in terms of clinical recovery, shorter duration of viral carriage, community spread prevention, and minimal cost of therapy. KeywordsHydroxychloroquine, Azithromycin, Ivermectin, COVID-19 patients