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All Studies   All Outcomes    Recent:   

Effectiveness of Molnupiravir Treatment in Patients with COVID-19 in Korea: A Propensity Score Matched Study

Park et al., Infection & Chemotherapy, doi:10.3947/ic.2023.0087
Nov 2023  
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Mortality 25% Improvement Relative Risk Progression 29% Molnupiravir  Park et al.  EARLY TREATMENT Is early treatment with molnupiravir beneficial for COVID-19? Retrospective 953,460 patients in South Korea (Aug 2022 - Mar 2023) Lower mortality (p<0.0001) and progression (p<0.0001) c19early.org Park et al., Infection & Chemotherapy, Nov 2023 Favorsmolnupiravir Favorscontrol 0 0.5 1 1.5 2+
PSM retrospective 190,692 COVID-19 patients treated with molnupiravir and 762,768 matched controls, showing lower mortality and combined severe/critical illness and mortality with treatment.
Confounding by treatment propensity. This study analyzes a population where only a fraction of eligible patients received the treatment. Patients receiving treatment may be more likely to follow other recommendations, more likely to receive additional care, and more likely to use additional treatments that are not tracked in the data (e.g., nasal/oral hygiene1,2, vitamin D3, etc.) — either because the physician recommending molnupiravir also recommended them, or because the patient seeking out molnupiravir is more likely to be familiar with the efficacy of additional treatments and more likely to take the time to use them. Therefore, these kind of studies may overestimate the efficacy of treatments.
Potential risks include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity4-13. Multiple analyses have identified variants potentially created by molnupiravir14-17.
risk of death, 25.1% lower, OR 0.75, p < 0.001, RR approximated with OR.
risk of progression, 28.6% lower, OR 0.71, p < 0.001, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Park et al., 22 Nov 2023, retrospective, South Korea, peer-reviewed, 6 authors, study period 1 August, 2022 - 31 March, 2023. Contact: erijykim@korea.kr.
This PaperMolnupiravirAll
Effectiveness of Molnupiravir Treatment in Patients with COVID-19 in Korea: A Propensity Score Matched Study
Hye Rim Park, Min-Gyu Yoo, Jong Mu Kim, Soon Jong Bae, Hyungmin Lee, PhD Jungyeon Kim
Infection & Chemotherapy, doi:10.3947/ic.2023.0087
Background: The MOVe-OUT (efficacy and safety of molnupiravir in non-hospitalized adult participants with ) trial reported that the administration of molnupiravir in unvaccinated patients with coronavirus disease 2019 (COVID-19) before the Omicron epidemic showed a preventive effect of 31% against hospitalization and death. However, studies on the preventive effect of molnupiravir against progression to severe disease and death in patients with COVID-19 during the Omicron epidemic are limited. This study aimed to evaluate the preventive effect of molnupiravir against severe/critical illness or death and death in Korean patients with COVID-19 who were vaccinated mostly during the Omicron epidemic. Materials and Methods: This study used large-scale retrospective cohort data to select patients with COVID-19 who were either treated or not treated with molnupiravir, between August 2022 and March 2023, at a ratio of 1 : 4 using the propensity score matching method. In total, 762,768 patients comprised the non-administered group, and 190,692 patients comprised the molnupiravir-administered group. The preventive effect of molnupiravir against severe/ critical illness or death and death was analyzed using logistic regression analysis. Results: The preventive effect of molnupiravir against severe/critical illness or death and death, represented by the odds ratio (OR) and 95% confidence interval (CI), in the molnupiravir-administered and non-administered group was (OR: 0.714; CI: 0.667 -0.764) and (OR: 0.749; CI: 0.682 -0.823), respectively. As age increased, the preventive effect against severe/critical illness or death and death increased. The preventive effect against severe/critical illness or death at ≥60 years was (OR: 0.
Conflict of interest No conflict of interest. Author Contributions
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