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Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
Ostrov et al., Pathogens, doi:10.3390/pathogens10111514 (In Vitro)
Ostrov et al., Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells, Pathogens, doi:10.3390/pathogens10111514 (In Vitro)
Nov 2021   Source   PDF  
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Vero E6 and H23 In Vitro study finding SARS-CoV-2 antiviral activity associated with agonism of the sigma-1 receptor, ligation of the sigma-2 receptor, and a combination of the two. Authors identify synergistic effects with the combination of diphenhydramine and lactoferrin.
5 In Vitro studies support the efficacy of lactoferrin [Cutone, Mirabelli, Ostrov, Piacentini, Salaris].
Ostrov et al., 20 Nov 2021, peer-reviewed, 16 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Abstract: pathogens Article Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells David A. Ostrov 1 , Andrew P. Bluhm 2,3 , Danmeng Li 1 , Juveriya Qamar Khan 4 , Megha Rohamare 4 , Karthic Rajamanickam 5 , Kalpana K. Bhanumathy 5 , Jocelyne Lew 6 , Darryl Falzarano 6 , Franco J. Vizeacoumar 5,7 , Joyce A. Wilson 4 , Marco Mottinelli 8 , Siva Rama Raju Kanumuri 9,10 , Abhisheak Sharma 9,10 , Christopher R. McCurdy 8,10 and Michael H. Norris 2,3, * 1 2 3 4 5 6   7 8 Citation: Ostrov, D.A.; Bluhm, A.P.; Li, D.; Khan, J.Q.; Rohamare, M.; Rajamanickam, K.; K. Bhanumathy, 9 10 K.; Lew, J.; Falzarano, D.; Vizeacoumar, F.J.; et al. Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells. Pathogens 2021, 10, 1514. 10.3390/pathogens10111514 Academic Editor: Lawrence S. Young Received: 14 October 2021 Accepted: 17 November 2021 Published: 20 November 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/). * Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA; (D.A.O.); (D.L.) Department of Geography, University of Florida College of Liberal Arts and Sciences, Gainesville, FL 32611, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; (J.Q.K.); (M.R.); (J.A.W.) Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; (K.R.); (K.K.B.); (F.J.V.) Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; (J.L.); (D.F.) Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA; (M.M.); (C.R.M.) Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA; (S.R.R.K.); (A.S.) Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute, Gainesville, FL 32610, USA Correspondence: Abstract: (1) Background: There is a strong need for prevention and treatment strategies for COVID19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus induced cellular toxicity. This study found antiviral..
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