Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
Ostrov et al.,
Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells,
Pathogens, doi:10.3390/pathogens10111514 (In Vitro)
Vero E6 and H23
In Vitro study finding SARS-CoV-2 antiviral activity associated with agonism of the sigma-1 receptor, ligation of the sigma-2 receptor, and a combination of the two. Authors identify synergistic effects with the combination of diphenhydramine and lactoferrin.
5 In Vitro studies support the efficacy of lactoferrin
[Cutone, Mirabelli, Ostrov, Piacentini, Salaris].
Ostrov et al., 20 Nov 2021, peer-reviewed, 16 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
Abstract: pathogens
Article
Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral
Properties in SARS-CoV-2 Infected Cells
David A. Ostrov 1 , Andrew P. Bluhm 2,3 , Danmeng Li 1 , Juveriya Qamar Khan 4 , Megha Rohamare 4 ,
Karthic Rajamanickam 5 , Kalpana K. Bhanumathy 5 , Jocelyne Lew 6 , Darryl Falzarano 6 ,
Franco J. Vizeacoumar 5,7 , Joyce A. Wilson 4 , Marco Mottinelli 8 , Siva Rama Raju Kanumuri 9,10 ,
Abhisheak Sharma 9,10 , Christopher R. McCurdy 8,10 and Michael H. Norris 2,3, *
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Citation: Ostrov, D.A.; Bluhm, A.P.;
Li, D.; Khan, J.Q.; Rohamare, M.;
Rajamanickam, K.; K. Bhanumathy,
9
10
K.; Lew, J.; Falzarano, D.;
Vizeacoumar, F.J.; et al. Highly
Specific Sigma Receptor Ligands
Exhibit Anti-Viral Properties in
SARS-CoV-2 Infected Cells. Pathogens
2021, 10, 1514. https://doi.org/
10.3390/pathogens10111514
Academic Editor: Lawrence S. Young
Received: 14 October 2021
Accepted: 17 November 2021
Published: 20 November 2021
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4.0/).
*
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine,
Gainesville, FL 32610, USA; ostroda@pathology.ufl.edu (D.A.O.); dameng1986@ufl.edu (D.L.)
Department of Geography, University of Florida College of Liberal Arts and Sciences, Gainesville, FL 32611,
USA; abluhm@ufl.edu
Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA
Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan,
Saskatoon, SK S7N 5E5, Canada; jqk913@mail.usask.ca (J.Q.K.); mrr968@mail.usask.ca (M.R.);
joyce.wilson@usask.ca (J.A.W.)
Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada;
kar029@mail.usask.ca (K.R.); kak677@mail.usask.ca (K.K.B.); franco.vizeacoumar@usask.ca (F.J.V.)
Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan,
Saskatoon, SK S7N 5E3, Canada; jocelyne.lew@usask.ca (J.L.); darryl.falzarano@usask.ca (D.F.)
Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada
Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA;
m.mottinelli@cop.ufl.edu (M.M.); cmccurdy@cop.ufl.edu (C.R.M.)
Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA;
kanumuris@cop.ufl.edu (S.R.R.K.); asharma1@cop.ufl.edu (A.S.)
Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute,
Gainesville, FL 32610, USA
Correspondence: mhnorris@ufl.edu
Abstract: (1) Background: There is a strong need for prevention and treatment strategies for COVID19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus
infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2
proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor
ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus
induced cellular toxicity. This study found antiviral..
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