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Content and characteristics of ivermectin in master formulations

Huerta León et al., Revista Cubana de Medicina Militar, 53:4
Nov 2024  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19ivm.org
Analysis of ivermectin in Peru showing significant variability in quality and concentration, with several formulations falling below the required dosage standards (36.2%-95.8%). Dosage inconsistencies were identified in products from private health institutions and specialized pharmacies, with potential implications for therapeutic efficacy. pH values varied widely (3.02 - 7.10), which might impact the stability and effectiveness of the drug. Variability in organoleptic characteristics was also noted, suggesting deficiencies in production standardization.
Huerta León et al., 25 Nov 2024, peer-reviewed, 7 authors.
This PaperIvermectinAll
Content and characteristics of ivermectin in master formulations
Jenny Rosalyn, Huerta León, Jhonnel Williams, Samaniego Joaquin, Jessica Benites Guerrero, Lizbeth Sánchez Pillaca, Luz Mery, Tito Quispe, Córdova Gerson, Serrano
RESUMEN Introducción: Tras la declaración de la COVID-19 como pandemia, la búsqueda de tratamientos se intensificó. En Perú, la ivermectina se propuso como tratamiento inicial por su supuesta seguridad, recomendándose para reducir la carga viral. Objetivo: Determinar el contenido y características de ivermectina en fórmulas magistrales. Métodos: Estudio cuantitativo, descriptivo transversal. Se analizaron fórmulas magistrales de ivermectina en gotas (6 mg/mL) en Lima: 3 de farmacias especializadas (muestras A, B, C), 2 de una entidad de salud privada (D, E), 1 de una entidad estatal (F) y 1 producto comercial (G). Se realizó dosificación por cromatografía líquida de alta resolución, además de medir características organolépticas y pH.
References
Bibliográficas, None
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Granda, Manual de metodología de la investigación científica
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Mery, Quispe, Serrano, Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Validation of Analytical Procedures: Text and Methodology Q2 (R1)
Nastaran, Motavallihaghi, Nikfar, Chaichian, Momtazi-Borojeni, Potential therapeutic effects of ivermectin in covid-19 [Internet], Experimental Biology and Medicine, doi:10.1177/15353702221099579
Rojas, Castillo, Estudio de Estabilidad Acelerada de cápsulas de Fluoxetina 20 mg, Internet
Verdú, Expertos de la UA en ivermectina destacan la disponibilidad global del antiparasitario que podría acabar con el Covid-19
Vázquez, González, Dávila, Crespo, Determinación del pH como criterio de calidad en la elaboración de fórmulas magistrales orales líquidas [Internet, Farm Hosp
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