Abstract: Review Article ISSN 2639-9458 Microbiology & Infectious Diseases Ivermectin as Prophylaxis Against COVID-19 Retrospective Cases Evaluation Hirsch, Roberto R1* and Carvallo, Hector E2 Former Professor of Infectology, University of Buenos Aires, Argentina. Director Career for Infectology Specialist, Hospital F. J. Muñíz, Argentina. Director Department of Infectious Diseases, Hospital F. J. Muñíz, Argentina. 1 Former Professor of Internal Medicine, University of Buenos Aires, Argentina. Former Director of Ezeiza´s Public Hospital, Argentina. Professor of Internal Medicine, Universidad Abierta Interamericana, Argentina. 2 * Correspondence: Roberto R Hirsch, Former Professor of Infectology, University of Buenos Aires, Argentina, E-mail: rrhirsch@intramed.net. Received: 29 November 2020; Accepted: 22 December 2020 Citation: Hirsch RR, Carvallo, Héctor E. Ivermectin as Prophylaxis Against COVID-19 Retrospective Cases Evaluation. Microbiol Infect Dis. 2020; 4(4): 1-8. ABSTRACT The current SARS COV2 (COVID 19) pandemic has generated a high number of infections among Health Agents. Around 25% of them have had to leave - temporarily or permanently - their jobs, due to having contracted the disease. Likewise, numerous deaths have been lamented within this group, which acts as the first defense against this and other pathologies that threaten the individual. All this has happened despite Personal Protective Equipments (PPEs), which makes it essential to optimize -from the pharmacological point of view- these elements, in order to reduce the risk of contagion as much as possible. In this sense, Ivermectin has shown its usefulness against SARS COV2, both in treatment and in prophylaxis. Therefore, this work compiles the characteristics of the group of Health Agents (and their close contacts) from a Buenos Aires Hospital specialized in Infectious Diseases, who resorted to it, as well as the results that were obtained. Keywords protein S (spike) [1].