Cholinergic eubiosis: A hypothesis on Ivermectin-upregulated Bifidobacterium

DOI record: { "DOI": "10.1016/j.mehy.2025.111613", "ISSN": [ "0306-9877" ], "URL": "http://dx.doi.org/10.1016/j.mehy.2025.111613", "alternative-id": [ "S0306987725000520" ], "article-number": "111613", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Cholinergic eubiosis: A hypothesis on Ivermectin-upregulated Bifidobacterium" }, { "label": "Journal Title", "name": "journaltitle", "value": "Medical Hypotheses" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.mehy.2025.111613" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2025 Published by Elsevier Ltd." } ], "author": [ { "affiliation": [], "family": "Hazan", "given": "Sabine", "sequence": "first" }, { "affiliation": [], "family": "Vidal", "given": "Adriana C.", "sequence": "additional" }, { "affiliation": [], "family": "Sfera", "given": "Adonis", "sequence": "additional" } ], "container-title": "Medical Hypotheses", "container-title-short": "Medical Hypotheses", "content-domain": { "crossmark-restriction": true, "domain": [ "clinicalkey.fr", "clinicalkey.jp", "clinicalkey.es", "clinicalkey.com.au", "clinicalkey.com", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2025, 3, 31 ] ], "date-time": "2025-03-31T02:57:07Z", "timestamp": 1743389827000 }, "deposited": { "date-parts": [ [ 2025, 3, 31 ] ], "date-time": "2025-03-31T03:00:11Z", "timestamp": 1743390011000 }, "indexed": { "date-parts": [ [ 2025, 3, 31 ] ], "date-time": "2025-03-31T03:40:26Z", "timestamp": 1743392426960, "version": "3.40.3" }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2025, 3 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://www.elsevier.com/legal/tdmrep-license", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://doi.org/10.15223/policy-017", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://doi.org/10.15223/policy-037", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://doi.org/10.15223/policy-012", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://doi.org/10.15223/policy-029", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } }, { "URL": "https://doi.org/10.15223/policy-004", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 3, 1 ] ], "date-time": "2025-03-01T00:00:00Z", "timestamp": 1740787200000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S0306987725000520?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S0306987725000520?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "111613", "prefix": "10.1016", "published": { "date-parts": [ [ 2025, 3 ] ] }, "published-print": { "date-parts": [ [ 2025, 3 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1016/j.pt.2017.02.004", "article-title": "Ivermectin - Old Drug, New Tricks?", "author": "Laing", "doi-asserted-by": "crossref", "first-page": "463", "issue": "6", "journal-title": "Trends Parasitol", "key": "10.1016/j.mehy.2025.111613_b0005", "volume": "33", "year": "2017" }, { "article-title": "Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth", "author": "Zhou", "issue": "12", "journal-title": "Front Pharmacol", "key": "10.1016/j.mehy.2025.111613_b0010", "volume": "13", "year": "2021" }, { "DOI": "10.1113/JP271537", "article-title": "The intestinal cholinergic anti-inflammatory pathway", "author": "Goverse", "doi-asserted-by": "crossref", "first-page": "5771", "issue": "20", "journal-title": "J Physiol", "key": "10.1016/j.mehy.2025.111613_b0015", "volume": "594", "year": "2016" }, { "DOI": "10.1111/nmo.14456", "article-title": "Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction", "author": "Bonaz", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "Neurogastroenterol Motil", "key": "10.1016/j.mehy.2025.111613_b0020", "volume": "34", "year": "2022" }, { "DOI": "10.1111/j.0105-2896.2009.00880.x", "article-title": "Microbe-dendritic cell dialog controls regulatory T-cell fate", "author": "Grainger", "doi-asserted-by": "crossref", "first-page": "305", "issue": "1", "journal-title": "Immunol Rev", "key": "10.1016/j.mehy.2025.111613_b0025", "volume": "234", "year": "2010" }, { "DOI": "10.1080/19490976.2023.2291164", "article-title": "Bifidobacterium mechanisms of immune modulation and tolerance", "author": "Gavzy", "doi-asserted-by": "crossref", "issue": "2", "journal-title": "Gut Microbes", "key": "10.1016/j.mehy.2025.111613_b0030", "volume": "15", "year": "2023" }, { "DOI": "10.1073/pnas.1921223117", "article-title": "Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade", "author": "Sun", "doi-asserted-by": "crossref", "first-page": "27509", "issue": "44", "journal-title": "PNAS", "key": "10.1016/j.mehy.2025.111613_b0035", "volume": "117", "year": "2020" }, { "DOI": "10.1111/jam.12415", "article-title": "Summer Meeting 2013: growth and physiology of bifidobacteria", "author": "De Vuyst", "doi-asserted-by": "crossref", "first-page": "477", "issue": "3", "journal-title": "J Appl Microbiol", "key": "10.1016/j.mehy.2025.111613_b0040", "volume": "116", "year": "2014" }, { "DOI": "10.1016/j.sjbs.2021.10.068", "article-title": "Gut microbiota and immunity relevance in eubiosis and dysbiosis", "author": "Al-Rashidi", "doi-asserted-by": "crossref", "first-page": "1628", "issue": "3", "journal-title": "Saudi J Biol Sci", "key": "10.1016/j.mehy.2025.111613_b0045", "volume": "29", "year": "2022" }, { "DOI": "10.1038/mi.2013.121", "article-title": "Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells", "author": "Korn", "doi-asserted-by": "crossref", "first-page": "1045", "issue": "5", "journal-title": "Mucosal Immunol", "key": "10.1016/j.mehy.2025.111613_b0050", "volume": "7", "year": "2014" }, { "DOI": "10.4049/jimmunol.1002711", "article-title": "Cytokine-Induced Alterations of α7 Nicotinic Receptor in Colonic CD4 T Cells Mediate Dichotomous Response to Nicotine in Murine Models of Th1/Th17- versus Th2-Mediated Colitis", "author": "Galitovskiy", "doi-asserted-by": "crossref", "first-page": "2677", "issue": "5", "journal-title": "J Immunol 1", "key": "10.1016/j.mehy.2025.111613_b0055", "volume": "187", "year": "2011" }, { "DOI": "10.1128/genomeA.00709-15", "article-title": "Draft Genome Sequences of Bifidobacterium angulatum GT102 and Bifidobacterium adolescentis 150: Focusing on the Genes Potentially Involved in the Gut-Brain Axis", "author": "Dyachkova", "doi-asserted-by": "crossref", "first-page": "e00709", "issue": "4", "journal-title": "Genome Announc", "key": "10.1016/j.mehy.2025.111613_b0060", "volume": "3", "year": "2015" }, { "DOI": "10.1245/s10434-011-2064-x", "article-title": "NNK Enhances Cell Migration through α7-nicotinic Acetylcholine Receptor Accompanied by Increased of Fibronectin Expression in Gastric Cancer", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "580", "issue": "Suppl 3", "journal-title": "Ann Surg Oncol", "key": "10.1016/j.mehy.2025.111613_b0065", "volume": "19", "year": "2012" }, { "DOI": "10.7150/ijbs.16404", "article-title": "The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism", "author": "Ren", "doi-asserted-by": "crossref", "first-page": "46", "issue": "1", "journal-title": "Int J Biol Sci", "key": "10.1016/j.mehy.2025.111613_b0070", "volume": "13", "year": "2017" }, { "DOI": "10.1146/annurev-immunol-032414-112123", "article-title": "Interleukin-22: immunobiology and pathology", "author": "Dudakov", "doi-asserted-by": "crossref", "first-page": "747", "journal-title": "Annu Rev Immunol", "key": "10.1016/j.mehy.2025.111613_b0075", "volume": "33", "year": "2015" }, { "DOI": "10.3389/fmicb.2017.02345", "article-title": "Bifidobacteria and Their Molecular Communication with the Immune System", "author": "Ruiz", "doi-asserted-by": "crossref", "first-page": "2345", "issue": "8", "journal-title": "Front Microbiol", "key": "10.1016/j.mehy.2025.111613_b0080", "volume": "4", "year": "2017" }, { "DOI": "10.1038/s41598-023-47066-z", "article-title": "The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors", "author": "Haidar", "doi-asserted-by": "crossref", "first-page": "19668", "issue": "1", "journal-title": "Sci Rep", "key": "10.1016/j.mehy.2025.111613_b0085", "volume": "13", "year": "2023" }, { "DOI": "10.1093/toxsci/kfad094", "article-title": "Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants", "author": "Filipovic", "doi-asserted-by": "crossref", "first-page": "170", "issue": "2", "journal-title": "Toxicol Sci", "key": "10.1016/j.mehy.2025.111613_b0090", "volume": "196", "year": "2023" }, { "DOI": "10.3390/biomedicines10051087", "article-title": "Aryl hydrocarbon receptors: evidence of therapeutic targets in chronic inflammatory skin diseases", "author": "Kim", "doi-asserted-by": "crossref", "first-page": "1087", "issue": "5", "journal-title": "Biomedicines", "key": "10.1016/j.mehy.2025.111613_b0095", "volume": "10", "year": "2022" }, { "DOI": "10.3390/reports6030036", "article-title": "Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?", "author": "Sfera", "doi-asserted-by": "crossref", "first-page": "36", "journal-title": "Reports", "key": "10.1016/j.mehy.2025.111613_b0100", "volume": "6", "year": "2023" }, { "DOI": "10.1074/jbc.M111.262634", "article-title": "Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel", "author": "Lynagh", "doi-asserted-by": "crossref", "first-page": "43913", "issue": "51", "journal-title": "J Biol Chem", "key": "10.1016/j.mehy.2025.111613_b0105", "volume": "286", "year": "2011" }, { "DOI": "10.1074/jbc.M011264200", "article-title": "Ivermectin, an unconventional agonist of the glycine receptor chloride channel", "author": "Shan", "doi-asserted-by": "crossref", "first-page": "12556", "issue": "16", "journal-title": "J Biol Chem", "key": "10.1016/j.mehy.2025.111613_b0110", "volume": "276", "year": "2001" }, { "author": "Tofalo", "first-page": "16", "issue": "6", "journal-title": "Polyamines and Gut Microbiota Front Nutr", "key": "10.1016/j.mehy.2025.111613_b0115", "volume": "25", "year": "2019" }, { "DOI": "10.1038/s41598-023-38082-0", "article-title": "Study of the biosynthesis and functionality of polyphosphate in Bifidobacterium longum KABP042", "author": "Alcántara", "doi-asserted-by": "crossref", "first-page": "11076", "journal-title": "Sci Rep", "key": "10.1016/j.mehy.2025.111613_b0120", "volume": "13", "year": "2023" }, { "DOI": "10.1371/journal.pone.0182282", "article-title": "Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis", "author": "Tong", "doi-asserted-by": "crossref", "issue": "8", "journal-title": "PLoS One", "key": "10.1016/j.mehy.2025.111613_b0125", "volume": "12", "year": "2017" }, { "DOI": "10.1016/j.it.2020.09.007", "article-title": "Polyamines and Kynurenines at the Intersection of Immune Modulation", "author": "Proietti", "doi-asserted-by": "crossref", "first-page": "1037", "issue": "11", "journal-title": "Trends Immunol", "key": "10.1016/j.mehy.2025.111613_b0130", "volume": "41", "year": "2020" }, { "article-title": "Implication of the polyamine system in mental disorders", "author": "Fiori", "first-page": "102", "issue": "2", "journal-title": "J Psychiatry Neurosci", "key": "10.1016/j.mehy.2025.111613_b0135", "volume": "33", "year": "2008" }, { "DOI": "10.1038/s41467-020-16629-3", "article-title": "Polyamine regulation of ion channel assembly and implications for nicotinic acetylcholine receptor pharmacology", "author": "Dhara", "doi-asserted-by": "crossref", "first-page": "2799", "issue": "1", "journal-title": "Nat Commun", "key": "10.1016/j.mehy.2025.111613_b0140", "volume": "11", "year": "2020" }, { "DOI": "10.1016/j.cell.2014.03.011", "article-title": "Role of the microbiota in immunity and inflammation", "author": "Belkaid", "doi-asserted-by": "crossref", "first-page": "121", "issue": "1", "journal-title": "Cell", "key": "10.1016/j.mehy.2025.111613_b0145", "volume": "157", "year": "2014" }, { "DOI": "10.3390/ijms222413397", "article-title": "Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases", "author": "Wicherska-Pawłowska", "doi-asserted-by": "crossref", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2025.111613_b0150", "year": "2021" }, { "DOI": "10.1146/annurev-pathmechdis-012419-032847", "article-title": "DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation", "author": "Zindel", "doi-asserted-by": "crossref", "first-page": "493", "issue": "15", "journal-title": "Annu Rev Pathol", "key": "10.1016/j.mehy.2025.111613_b0155", "volume": "24", "year": "2020" }, { "DOI": "10.3390/ijms24010641", "article-title": "Acute Inflammation in Tissue Healing", "author": "Soliman", "doi-asserted-by": "crossref", "first-page": "641", "issue": "1", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2025.111613_b0160", "volume": "24", "year": "2022" }, { "DOI": "10.3389/fimmu.2020.00588", "article-title": "Mechanisms of Fetal T Cell Tolerance and Immune Regulation", "author": "Rackaityte", "doi-asserted-by": "crossref", "first-page": "588", "issue": "11", "journal-title": "Front Immunol", "key": "10.1016/j.mehy.2025.111613_b0165", "volume": "9", "year": "2020" }, { "DOI": "10.1084/jem.20192195", "article-title": "The role of IL-22 in intestinal health and disease", "author": "Keir", "doi-asserted-by": "crossref", "issue": "3", "journal-title": "J Exp Med", "key": "10.1016/j.mehy.2025.111613_b0170", "volume": "217", "year": "2020" }, { "DOI": "10.1038/s41418-020-00633-7", "article-title": "An aberrant STAT pathway is central to COVID-19", "author": "Matsuyama", "doi-asserted-by": "crossref", "first-page": "3209", "journal-title": "Cell Death Differ", "key": "10.1016/j.mehy.2025.111613_b0175", "volume": "27", "year": "2020" }, { "DOI": "10.1038/35013070", "article-title": "Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin", "author": "Borovikova", "doi-asserted-by": "crossref", "first-page": "458", "issue": "6785", "journal-title": "Nature", "key": "10.1016/j.mehy.2025.111613_b0180", "volume": "405", "year": "2000" }, { "DOI": "10.1016/j.drudis.2013.07.005", "article-title": "Novel anti-cholinergics in COPD", "author": "Prakash", "doi-asserted-by": "crossref", "first-page": "1117", "journal-title": "Drug Discov Today", "key": "10.1016/j.mehy.2025.111613_b0185", "volume": "18", "year": "2013" }, { "DOI": "10.1038/nature16504", "article-title": "Diet-induced extinctions in the gut microbiota compound over generations", "author": "Sonnenburg", "doi-asserted-by": "crossref", "first-page": "212", "issue": "7585", "journal-title": "Nature", "key": "10.1016/j.mehy.2025.111613_b0190", "volume": "529", "year": "2016" }, { "DOI": "10.1172/JCI76307", "article-title": "Building a second brain in the bowel", "author": "Avetisyan", "doi-asserted-by": "crossref", "first-page": "899", "issue": "3", "journal-title": "J Clin Invest", "key": "10.1016/j.mehy.2025.111613_b0195", "volume": "125", "year": "2015" }, { "article-title": "Recent advances in understanding the roles of the enteric nervous system", "author": "Chanpong", "first-page": "7", "issue": "11", "journal-title": "Fac Rev", "key": "10.1016/j.mehy.2025.111613_b0200", "volume": "24", "year": "2022" }, { "DOI": "10.1053/j.gastro.2017.05.003", "article-title": "Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome", "author": "Pinto-Sanchez", "doi-asserted-by": "crossref", "first-page": "448", "issue": "2", "journal-title": "Gastroenterology", "key": "10.1016/j.mehy.2025.111613_b0205", "volume": "153", "year": "2017" }, { "DOI": "10.1007/s44192-022-00006-1", "article-title": "The role of innate lymphoid cells (ILCs) in mental health", "author": "Barichello", "doi-asserted-by": "crossref", "first-page": "2", "issue": "1", "journal-title": "Discov Ment Health", "key": "10.1016/j.mehy.2025.111613_b0210", "volume": "2", "year": "2022" }, { "article-title": "Brain signatures of chronic gut inflammation", "author": "Hall", "issue": "14", "journal-title": "Front Psychiatry", "key": "10.1016/j.mehy.2025.111613_b0215", "volume": "7", "year": "2023" }, { "DOI": "10.1002/ctm2.1417", "article-title": "Human gut-associated lymphoid tissue: A dynamic hub propagating modulators of inflammation", "author": "Jain", "doi-asserted-by": "crossref", "first-page": "e1417", "issue": "9", "journal-title": "Clin Transl Med", "key": "10.1016/j.mehy.2025.111613_b0220", "volume": "13", "year": "2023" }, { "article-title": "Innate Lymphoid Cells in the Central Nervous System", "author": "Wang", "issue": "13", "journal-title": "Front Immunol", "key": "10.1016/j.mehy.2025.111613_b0225", "volume": "3", "year": "2022" }, { "DOI": "10.1126/science.aaa6566", "article-title": "Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology", "author": "Eberl", "doi-asserted-by": "crossref", "journal-title": "Science", "key": "10.1016/j.mehy.2025.111613_b0230", "year": "2015" }, { "DOI": "10.1038/nri2476", "article-title": "GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation", "author": "Ho", "doi-asserted-by": "crossref", "first-page": "125", "issue": "2", "journal-title": "Nat Rev Immunol", "key": "10.1016/j.mehy.2025.111613_b0235", "volume": "9", "year": "2009" }, { "DOI": "10.1016/j.immuni.2016.12.009", "article-title": "Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution", "author": "Dalli", "doi-asserted-by": "crossref", "first-page": "92", "issue": "1", "journal-title": "Immunity", "key": "10.1016/j.mehy.2025.111613_b0240", "volume": "46", "year": "2017" }, { "DOI": "10.3390/cells12020314", "article-title": "MHC Class II Presentation in Autoimmunity", "author": "Ishina", "doi-asserted-by": "crossref", "first-page": "314", "issue": "2", "journal-title": "Cells", "key": "10.1016/j.mehy.2025.111613_b0245", "volume": "12", "year": "2023" }, { "DOI": "10.1038/s41586-019-1238-8", "doi-asserted-by": "crossref", "first-page": "641", "journal-title": "Nature", "key": "10.1016/j.mehy.2025.111613_b0250", "volume": "569", "year": "2019" }, { "DOI": "10.1038/s41577-021-00595-y", "article-title": "The discovery of innate lymphoid cells", "author": "Vivier", "doi-asserted-by": "crossref", "first-page": "616", "journal-title": "Nat Rev Immunol", "key": "10.1016/j.mehy.2025.111613_b0255", "volume": "21", "year": "2021" }, { "author": "Kraepelin", "key": "10.1016/j.mehy.2025.111613_b0260", "series-title": "Psychiatrie. Ein kurzes Lehrbuch für Studirende und Aerzte. Vierte, vollständig umgearbeitete Aufl age", "year": "1893" }, { "DOI": "10.3389/fnins.2020.00284", "article-title": "Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice", "author": "Yap", "doi-asserted-by": "crossref", "first-page": "284", "issue": "14", "journal-title": "Front Neurosci", "key": "10.1016/j.mehy.2025.111613_b0265", "volume": "28", "year": "2020" }, { "DOI": "10.1073/pnas.2303525120", "article-title": "Acetylcholine-producing CD4 T cells regulate vasculature in humans", "author": "Cox", "doi-asserted-by": "crossref", "issue": "16", "journal-title": "Proc Natl Acad Sci U S A", "key": "10.1016/j.mehy.2025.111613_b0270", "volume": "120", "year": "2023" }, { "DOI": "10.1126/science.1209985", "article-title": "Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit", "author": "Rosas-Ballina", "doi-asserted-by": "crossref", "first-page": "98", "journal-title": "Science", "key": "10.1016/j.mehy.2025.111613_b0275", "volume": "334", "year": "2011" }, { "DOI": "10.1007/s10620-019-05838-6", "article-title": "Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis", "author": "Singh", "doi-asserted-by": "crossref", "first-page": "141", "issue": "1", "journal-title": "Dig Dis Sci", "key": "10.1016/j.mehy.2025.111613_b0280", "volume": "65", "year": "2020" }, { "DOI": "10.3390/ijms241612648", "article-title": "Long COVID as a Tauopathy: Of “Brain Fog” and “Fusogen Storms”", "author": "Sfera", "doi-asserted-by": "crossref", "first-page": "12648", "issue": "16", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2025.111613_b0285", "volume": "24", "year": "2023" }, { "DOI": "10.1016/j.schres.2018.01.010", "article-title": "Non-invasive brain stimulation for negative symptoms in schizophrenia: An updated systematic review and meta-analysis", "author": "Osoegawa", "doi-asserted-by": "crossref", "first-page": "34", "journal-title": "Schizophr Res", "key": "10.1016/j.mehy.2025.111613_b0290", "volume": "197", "year": "2018" }, { "DOI": "10.2174/156802606776894465", "article-title": "Glycine/NMDA receptor antagonists as potential CNS therapeutic agents: ACEA-1021 and related compounds", "author": "Cai", "doi-asserted-by": "crossref", "first-page": "651", "issue": "7", "journal-title": "Curr Top Med Chem", "key": "10.1016/j.mehy.2025.111613_b0295", "volume": "6", "year": "2006" }, { "DOI": "10.1016/j.rvsc.2019.03.009", "article-title": "Therapeutical doses of ivermectin and its association with stress disrupt motor and social behaviors of juvenile rats and serotonergic and dopaminergic systems", "author": "Parisi", "doi-asserted-by": "crossref", "first-page": "149", "journal-title": "Res Vet Sci", "key": "10.1016/j.mehy.2025.111613_b0300", "volume": "124", "year": "2019" }, { "DOI": "10.1186/s13578-024-01228-2", "article-title": "Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function", "author": "Wadsworth", "doi-asserted-by": "crossref", "first-page": "50", "journal-title": "Cell Biosci", "key": "10.1016/j.mehy.2025.111613_b0305", "volume": "14", "year": "2024" }, { "DOI": "10.1097/MD.0000000000037114", "article-title": "The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review", "author": "Mhanna", "doi-asserted-by": "crossref", "issue": "5", "journal-title": "Medicine (Baltimore)", "key": "10.1016/j.mehy.2025.111613_b0310", "volume": "103", "year": "2024" }, { "DOI": "10.1186/s13756-018-0314-4", "article-title": "In vitro activity of ivermectin against Staphylococcus aureus clinical isolates", "author": "Ashraf", "doi-asserted-by": "crossref", "first-page": "27", "issue": "7", "journal-title": "Antimicrob Resist Infect Control", "key": "10.1016/j.mehy.2025.111613_b0315", "volume": "20", "year": "2018" }, { "DOI": "10.4103/idoj.idoj_298_21", "doi-asserted-by": "crossref", "key": "10.1016/j.mehy.2025.111613_b0320", "unstructured": "Mathachan SR, Sardana K, Khurana A. Current Use of Ivermectin in Dermatology, Tropical Medicine, and COVID-19: An Update on Pharmacology, Uses, Proven and Varied Proposed Mechanistic Action. Indian Dermatol Online J. 2021 Jul 14;12(4):500-514. And this article:" }, { "article-title": "Effect of the endectocide ivermectin on filamentous fungi", "author": "Kollmann", "first-page": "215", "issue": "3", "journal-title": "Environ Chem Lett", "key": "10.1016/j.mehy.2025.111613_b0325", "volume": "1", "year": "2004" }, { "DOI": "10.3390/antibiotics10020208", "article-title": "A Novel Ivermectin-Derived Compound D4 and Its Antimicrobial/Biofilm Properties against MRSA", "author": "Tan", "doi-asserted-by": "crossref", "first-page": "208", "issue": "2", "journal-title": "Antibiotics (Basel)", "key": "10.1016/j.mehy.2025.111613_b0330", "volume": "10", "year": "2021" }, { "DOI": "10.1080/14656566.2021.1873951", "article-title": "Current and promising pharmacotherapeutic options for candidiasis", "author": "Scorzoni", "doi-asserted-by": "crossref", "first-page": "867", "issue": "7", "journal-title": "Expert Opin Pharmacother", "key": "10.1016/j.mehy.2025.111613_b0335", "volume": "22", "year": "2021" }, { "article-title": "Engineered Ripening-Specific Accumulation of Polyamines Spermidine and Spermine in Tomato Fruit Upregulates Clustered C/D Box snoRNA Gene Transcripts in Concert with Ribosomal RNA Biogenesis in the Red Ripe Fruit", "author": "Shukla", "first-page": "1710", "issue": "12", "journal-title": "Plants (Basel)", "key": "10.1016/j.mehy.2025.111613_b0340", "volume": "9", "year": "2020" }, { "article-title": "Possible Biological and Clinical Applications of Phenothiazines", "author": "Varga", "first-page": "5983", "issue": "11", "journal-title": "Anticancer Res", "key": "10.1016/j.mehy.2025.111613_b0345", "volume": "37", "year": "2017" }, { "DOI": "10.3390/ijms25115904", "article-title": "Novel Insights into Psychosis and Antipsychotic Interventions: From Managing Symptoms to Improving Outcomes", "author": "Sfera", "doi-asserted-by": "crossref", "first-page": "5904", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2025.111613_b0350", "volume": "25", "year": "2024" }, { "DOI": "10.1016/j.vetpar.2024.110241", "article-title": "The effect of anthelmintic treatment and efficacy on the faecal microbiota of healthy adult horses", "author": "Bell", "doi-asserted-by": "crossref", "journal-title": "Vet Parasitol", "key": "10.1016/j.mehy.2025.111613_b0355", "volume": "330", "year": "2024" }, { "article-title": "Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas", "author": "Ma", "first-page": "169", "issue": "2", "journal-title": "Vet Sci", "key": "10.1016/j.mehy.2025.111613_b0360", "volume": "10", "year": "2023" }, { "DOI": "10.3390/ijms242216125", "article-title": "Impact of Ivermectin on the Gut Microbial Ecosystem", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "16125", "issue": "22", "journal-title": "Int J Mol Sci", "key": "10.1016/j.mehy.2025.111613_b0365", "volume": "24", "year": "2023" }, { "DOI": "10.1177/1753425918785016", "article-title": "Aryl hydrocarbon receptor/IL-22/Stat3 signaling pathway is involved in the modulation of intestinal mucosa antimicrobial molecules by commensal microbiota in mice", "author": "Wang", "doi-asserted-by": "crossref", "first-page": "297", "issue": "5", "journal-title": "Innate Immun", "key": "10.1016/j.mehy.2025.111613_b0370", "volume": "24", "year": "2018" }, { "DOI": "10.1186/s11658-021-00249-w", "article-title": "The NOTCH-HES-1 axis is involved in promoting Th22 cell differentiation", "author": "Zeng", "doi-asserted-by": "crossref", "first-page": "7", "issue": "1", "journal-title": "Cell Mol Biol Lett", "key": "10.1016/j.mehy.2025.111613_b0375", "volume": "26", "year": "2021" }, { "DOI": "10.3389/fmed.2018.00124", "article-title": "Strain-specificity and disease-specificity of probiotic efficacy: a systematic review and meta-analysis", "author": "McFarland", "doi-asserted-by": "crossref", "first-page": "124", "issue": "5", "journal-title": "Front Med", "key": "10.1016/j.mehy.2025.111613_b0380", "volume": "7", "year": "2018" }, { "DOI": "10.1038/s41598-023-27706-0", "article-title": "Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum", "author": "Ma", "doi-asserted-by": "crossref", "first-page": "1023", "issue": "1", "journal-title": "Sci Rep", "key": "10.1016/j.mehy.2025.111613_b0385", "volume": "13", "year": "2023" }, { "DOI": "10.3390/nu17030391", "article-title": "Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review", "author": "Reiriz", "doi-asserted-by": "crossref", "first-page": "391", "issue": "3", "journal-title": "Nutrients", "key": "10.1016/j.mehy.2025.111613_b0390", "volume": "17", "year": "2025" }, { "DOI": "10.1186/s13099-024-00634-8", "article-title": "Strain-specific effects of probiotics on depression and anxiety: a meta-analysis", "author": "Rahmannia", "doi-asserted-by": "crossref", "first-page": "46", "journal-title": "Gut Pathog", "key": "10.1016/j.mehy.2025.111613_b0395", "volume": "16", "year": "2024" }, { "DOI": "10.1007/s10753-023-01829-y", "article-title": "Ivermectin Protects Against Experimental Autoimmune Encephalomyelitis in Mice by Modulating the Th17/Treg Balance Involved in the IL-2/STAT5 Pathway", "author": "Xie", "doi-asserted-by": "crossref", "first-page": "1626", "journal-title": "Inflammation", "key": "10.1016/j.mehy.2025.111613_b0400", "volume": "46", "year": "2023" }, { "DOI": "10.1007/s10522-018-9745-9", "article-title": "Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers", "author": "Snell", "doi-asserted-by": "crossref", "first-page": "145", "issue": "2", "journal-title": "Biogerontology", "key": "10.1016/j.mehy.2025.111613_b0405", "volume": "19", "year": "2018" }, { "DOI": "10.1186/s40168-019-0644-3", "article-title": "Interactions between a pathogenic Blastocystis subtype and gut microbiota: in vitro and in vivo studies", "author": "Yason", "doi-asserted-by": "crossref", "first-page": "30", "journal-title": "Microbiome", "key": "10.1016/j.mehy.2025.111613_b0410", "volume": "7", "year": "2019" }, { "DOI": "10.1186/s40168-023-01486-1", "article-title": "IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans", "author": "Mar", "doi-asserted-by": "crossref", "first-page": "47", "journal-title": "Microbiome", "key": "10.1016/j.mehy.2025.111613_b0415", "volume": "11", "year": "2023" }, { "article-title": "Ivermectin (IVM) Possible Side Activities and Implications in Antimicrobial Resistance and Animal Welfare: The Authors' Perspective", "author": "Piras", "first-page": "24", "issue": "1", "journal-title": "Vet Sci", "key": "10.1016/j.mehy.2025.111613_b0420", "volume": "9", "year": "2022" }, { "DOI": "10.1017/S0007114518001563", "article-title": "Killed Bifidobacterium longum enhanced stress tolerance and prolonged life span of Caenorhabditis elegans via DAF-16", "author": "Sugawara", "doi-asserted-by": "crossref", "first-page": "872", "issue": "8", "journal-title": "Br J Nutr", "key": "10.1016/j.mehy.2025.111613_b0425", "volume": "120", "year": "2018" }, { "DOI": "10.1016/j.ebiom.2023.104566", "article-title": "Circulating markers of microbial translocation and host response to bacteria with risk of colorectal cancer: a prospective, nested case-control study in men", "author": "Shi", "doi-asserted-by": "crossref", "journal-title": "EBioMedicine", "key": "10.1016/j.mehy.2025.111613_b0430", "volume": "91", "year": "2023" }, { "article-title": "Relevance of biomarkers indicating gut damage and microbial translocation in people living with HIV", "author": "Ouyang", "issue": "14", "journal-title": "Front Immunol", "key": "10.1016/j.mehy.2025.111613_b0435", "volume": "21", "year": "2023" } ], "reference-count": 87, "references-count": 87, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0306987725000520" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Cholinergic eubiosis: A hypothesis on Ivermectin-upregulated Bifidobacterium", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy" }