COVID-19: Effectiveness of pre-exposure prophylaxis with ivermectin in exposed persons
et al., ResearchGate
Pre-exposure prophylaxis study with 129 people split into high/low exposure groups, with each group split into different dosing regimens, showing higher effectivess with more frequent doses.
every 7 days dosing: 0 of 20 cases, 100% effective
every 14 days dosing: 1 of 47 cases, 98% effective
every 30 days dosing: 2 of 20 cases, 90% effective
every 14 days dosing: 0 of 21 cases, 100% effective
every 30 days dosing: 1 of 20 cases, 95% effective
Chang et al., 31 Oct 2020, preprint, 2 authors.
Abstract: See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/347890660
COVID-19: EFFICACY OF PRE-EXPOSURE PROPHYLAXIS WITH IVERMECTIN
IN EXPOSED PERSONS
Preprint · October 2020
Gustavo Aguirre Chang
Aurora Natividad Trujillo Figueredo
National University of San Marcos
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COVID-19: EFFICACY OF PRE-EXPOSURE PROPHYLAXIS WITH
IVERMECTIN IN EXPOSED PERSONS
Aguirre-Chang, Gustavo and Trujillo F., Aurora. ResearchGate. October 22,
The use of Ivermectin as massive prophylaxis has been a policy of the World Health
Organization (WHO) for decades and its application in several countries allowed the
eradication of the serious disease Onchocerciasis that causes the so-called “river blindness”.
In merit of the great benefits obtained in these Programs, is that the creators of Ivermectin
were awarded the Nobel Prize in 2015.
Its massive prophylactic use has also been indicated for intestinal parasites and ectoparasites
such as scabies.
In March 2020, the WHO declared the COVID-19 pandemic. Having a very wide experience
in the use of Ivermectin in humans, and its use being safe, even at doses above the regular
ones, it is necessary in the short term to start tests to extend its use in massive programs that
include the COVID-19 disease.
MATERIAL AND METHODS:
Participants enrolled between April 7 and July 31, 2020. 2 groups were established:
Group 1: People who go to places of high risk of exposure. In this group 88 people were
enrolled, and 3 subgroups were established with frequencies in the Ivermectin dose of: every
7 days, every 14 days and every 30 days
Group 2: People who do not go to places of high risk of exposure. 41 people were enrolled,
and 2 subgroups were established with frequencies of: every 14 days and every 30 days
Hospitals, Health Centers, Markets and the like, Fairs, Land Terminals, Airports and other
places with a high influx of people, in a town where there is community transmission of the
infection by the SARS CoV-2 were considered as places of high risk of exposure.
In all participants, the standard Ivermectin dose of 0.2 mg. per kilo of weight per day (or 0.091
mg. per pound of weight) was established.
For the frequencies of every 14 and 30 days of both groups, the month that the prophylaxis
began, it was indicated to take a second dose at 7 days, and then continue with the
frequencies every 14 and 30 days counting from the date of the first dose.
For both groups, it was indicated that they maintain all other Preventive Measures, such as
the use of a mask, social distancing, frequent hand washing, among others.
After the exclusions made, there were 129 participants who complied with the established
Pre-Exposure Prophylaxis (PrPE) regimens with Ivermectin, who were followed up until
October 21, 2020.
In Group 1: People who go to places of high risk of exposure. Of the 20 participants who
complied with the schedule of one dose of Ivermectin every 7 days, none developed COVID19..
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