Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Biancatelli et al.,
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2..,
Frontiers in Immunology, doi:10.3389/fimmu.2020.01451 (Review)
Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
Biancatelli et al., 19 Jun 2020, peer-reviewed, 4 authors.
Abstract: REVIEW
published: 19 June 2020
doi: 10.3389/fimmu.2020.01451
Quercetin and Vitamin C: An
Experimental, Synergistic Therapy
for the Prevention and Treatment of
SARS-CoV-2 Related Disease
(COVID-19)
Ruben Manuel Luciano Colunga Biancatelli 1,2,3*, Max Berrill 4 , John D. Catravas 1,2,5 and
Paul E. Marik 1
1
Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, Norfolk, VA, United States, 2 Frank Reidy
Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, United States, 3 Policlinico Umberto I, La Sapienza
University of Rome, Rome, Italy, 4 Department of Respiratory Medicine, St. Peter’s Hospital, Surrey, United Kingdom, 5 School
of Medical Diagnostic & Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA,
United States
Edited by:
Xulin Chen,
Jinan University, China
Reviewed by:
Vincent T. Chow,
National University of
Singapore, Singapore
Zhenlong Liu,
McGill University, Canada
*Correspondence:
Ruben Manuel Luciano Colunga
Biancatelli
ruben.colungabiancatelli@gmail.com
Specialty section:
This article was submitted to
Viral Immunology,
a section of the journal
Frontiers in Immunology
Received: 09 April 2020
Accepted: 04 June 2020
Published: 19 June 2020
Citation:
Colunga Biancatelli RML, Berrill M,
Catravas JD and Marik PE (2020)
Quercetin and Vitamin C: An
Experimental, Synergistic Therapy for
the Prevention and Treatment of
SARS-CoV-2 Related Disease
(COVID-19). Front. Immunol. 11:1451.
doi: 10.3389/fimmu.2020.01451
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an
emergent global threat which is straining worldwide healthcare capacity. As of May 27th,
the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000
deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study
and develop pharmacological treatments suitable for the prevention and treatment of
COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning
of the immune system. It plays a role in stress response and has shown promising
results when administered to the critically ill. Quercetin is a well-known flavonoid whose
antiviral properties have been investigated in numerous studies. There is evidence that
vitamin C and quercetin co-administration exerts a synergistic antiviral action due to
overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to
recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound
biological rationale should be prioritized for experimental use in the current context of a
global health pandemic. We present the current evidence for the use of vitamin C and
quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19
patients as an adjunct to promising pharmacological agents such as Remdesivir or
convalescent plasma.
Keywords: SARS-Cov-2, COVID-19, vitamin C, quercetin, flavonoids, antiviral, Coronavirus, immunonutrition
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