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Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

Biancatelli et al., Frontiers in Immunology, doi:10.3389/fimmu.2020.01451
Jun 2020  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021
 
*, now known with p = 0.0031 from 11 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Review of the evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients.
Reviews covering quercetin for COVID-19 include Agrawal, Biancatelli, Chen, Derosa, Dinda, Gasmi, Georgiou, Imran, Massimo Magro, Matías-Pérez, Mirza, Rizky, Shorobi, Vajdi, Yong.
Review covers vitamin C and quercetin.
Biancatelli et al., 19 Jun 2020, peer-reviewed, 4 authors.
This PaperQuercetinAll
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)
Ruben Manuel Luciano Colunga Biancatelli, Max Berrill, John D Catravas, Paul E Marik
Frontiers in Immunology, doi:10.3389/fimmu.2020.01451
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.
AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Copyright © 2020 Colunga Biancatelli, Berrill, Catravas and Marik. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
References
Abdelmoaty, Ibrahim, Ahmed, Abdelaziz, Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats, Indian J Clin Biochem, doi:10.1007/s12291-010-0034-x
Agullo, Gamet-Payrastre, Manenti, Viala, Rémésy et al., Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition, Biochem Pharmacol, doi:10.1016/S0006-2952(97)82453-7
Alvarez, Alvarado, Puerto, Schlumberger, Jiménez et al., Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol-rich cereals, Nutrition, doi:10.1016/j.nut.2005.12.012
Anderson, Smit, Joone, Van Staden, Vitamin C and cellular immune functions. Protection against hypochlorous acidmediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation, Ann N Y Acad Sci, doi:10.1111/j.1749-6632.1990.tb00131.x
Andrea, Day, Morgan, Characterization of polyphenols metabolites
Andres, Pevny, Ziegenhagen, Bakhiya, Schäfer et al., Safety aspects of the use of quercetin as a dietary supplement, Mol Nutr Food Res, doi:10.1002/mnfr.201700447
Askari, Ghiasvand, Feizi, Ghanadian, Karimian, The effect of quercetin supplementation on selected markers of inflammation and oxidative stress, J Res Med Sci
Atherton, Kratzing, Fisher, The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus, Arch Virol, doi:10.1007/BF01317848
Awad, Boersma, Boeren, Van Bladeren, Vervoort et al., Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation, Chem Res Toxicol, doi:10.1021/tx020079g
Awad, Boersma, Boeren, Van Der Woude, Van Zanden et al., Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system, FEBS Lett, doi:10.1016/S0014-5793(02)02754-0
Awad, Boersma, Rietjens, Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts, Arch Biochem Biophys, doi:10.1006/abbi.2000.1832
Bachmetov, Gal-Tanamy, Shapira, Vorobeychik, Giterman-Galam et al., Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity, J Viral Hepat, doi:10.1111/j.1365-2893.2011.01507.x
Banic, Prevention of rabies by vitamin C, Nature, doi:10.1038/258153a0
Beigel, Tomashek, Dodd, Mehta, Zingman et al., Remdesivir for the treatment of Covid-19 -preliminary report, N Engl J Med, doi:10.1056/NEJMoa2007764
Biancatelli, Berrill, Marik, The antiviral properties of vitamin C, Expert Rev Anti Infect Ther, doi:10.1080/14787210.2020.1706483
Biskind, Martin, The use of citrus flavonoids in respiratory infections, Am J Dig Dis, doi:10.1007/BF02886384
Boots, Balk, Bast, Haenen, The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity, Biochem Biophys Res Commun, doi:10.1016/j.bbrc.2005.10.031
Boots, Haenen, Bast, Health effects of quercetin: from antioxidant to nutraceutical, Eur J Pharmacol, doi:10.1016/j.ejphar.2008.03.008
Boots, Kubben, Haenen, Bast, Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation, Biochem Biophys Res Commun, doi:10.1016/S0006-291X(03)01438-4
Boots, Li, Schins, Duffin, Heemskerk et al., The quercetin paradox, Toxicol Appl Pharmacol, doi:10.1016/j.taap.2007.04.004
Bors, Michel, Schikora, Interaction of flavonoids with ascorbate and determination of their univalent redox potentials: a pulse radiolysis study, Free Radic Biol Med, doi:10.1016/0891-5849(95)00011-L
Brown, A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds, Mutat Res, doi:10.1016/0165-1110(80)90029-9
Burger, ChemDoodle web components: HTML5 toolkit for chemical graphics, interfaces, and informatics, J Cheminform, doi:10.1186/s13321-015-0085-3
Cai, Li, Tang, Tsoi, Chen et al., A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virusinduced pneumonia in restraint-stressed mice, BioMed Res Int, doi:10.1155/2015/675149
Cai, Rahn, Zhang, Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals, Cancer Lett, doi:10.1016/S0304-3835(97)00261-9
Carr, Lykkesfeldt, Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives, Crit Rev Food Sci Nutr, doi:10.1080/10408398.2020.1744513
Carr, Maggini, Vitamin C and Immune Function, Nutrients, doi:10.3390/nu9111211
Carr, Rosengrave, Bayer, Chambers, Mehrtens et al., Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes, Crit Care, doi:10.1186/s13054-017-1891-y
Castrillo, Carrasco, Action of 3-methylquercetin on poliovirus RNA replication, J Virol, doi:10.1128/JVI.61.10.3319-3321.1987
Chen, Chang, Feng, Chu, So et al., Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain, Clin J Pain, doi:10.1097/AJP.0b013e318193cf32
Chen, Li, Luo, Liu, Xu et al., Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features, Bioorg Med Chem, doi:10.1016/j.bmc.2006.09.014
Chiang, Chiang, Liu, Lin, In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids, J Antimicrob Chemother, doi:10.1093/jac/dkg291
Cinatl, Cinatl, Weber, Rabenau, Gumbel et al., In vitro inhibition of human cytomegalovirus replication in human foreskin fibroblasts and endothelial cells by ascorbic acid 2-phosphate, Antiviral Res, doi:10.1016/0166-3542(95)00024-G
Conti, Ronconi, Caraffa, Gallenga, Ross et al., Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies, J Biol Regul Homeost Agents, doi:10.23812/CONTI-E
Cushnie, Lamb, Antimicrobial activity of flavonoids, Int J Antimicrob Agents, doi:10.1016/j.ijantimicag.2005.09.002
Davies, Reddy, Caivano, Cohen, Specificity and mechanism of action of some commonly used protein kinase inhibitors, Biochem J, doi:10.1042/bj3510095
Davis, Murphy, Mcclellan, Carmichael, Gangemi, Quercetin reduces susceptibility to influenza infection following stressful exercise, Am J Physiol Regul Integr Comp Physiol, doi:10.1152/ajpregu.90319.2008
De Boer, Dihal, Van Der Woude, Arts, Wolffram, Tissue distribution of quercetin in rats and pigs, J Nutr, doi:10.1093/jn/135.7.1718
Debiaggi, Tateo, Pagani, Luini, Romero, Effects of propolis flavonoids on virus infectivity and replication, Microbiologica
Dey, Bishayi, Killing of S. aureus in murine peritoneal macrophages by Ascorbic acid along with antibiotics Chloramphenicol or Ofloxacin: correlation with inflammation, Microb Pathog, doi:10.1016/j.micpath.2017.12.048
Dimova, Mugabowindekwe, Willems, Brewster, Noppe et al., Safety-assessment of 3-methoxyquercetin as an antirhinoviral compound for nasal application: effect on ciliary beat frequency, Int J Pharm, doi:10.1016/S0378-5173(03)00363-6
Evers, Chao, Wang, Zhang, Huong et al., Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action, Antiviral Res, doi:10.1016/j.antiviral.2005.08.002
Exon, Magnuson, South, Hendrix, Effect of dietary chlorogenic acid on multiple immune functions and formation of aberrant crypt foci in rats, J Toxicol Environ Health A, doi:10.1080/009841098159231
Ferry, Smith, Malkhandi, Fyfe, Detakats et al., Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition, Clin Cancer Res
Formica, Regelson, Review of the biology of Quercetin and related bioflavonoids, Food Chem Toxicol, doi:10.1016/0278-6915(95)00077-1
Fowler, Iii, Truwit, Hite, Morris et al., Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial, JAMA, doi:10.1001/jama.2019.11825
Furuya, Uozaki, Yamasaki, Arakawa, Koyama, Antiviral effects of ascorbic and dehydroascorbic acids in vitro, Int J Mol Med, doi:10.3892/ijmm_00000053
Ganesan, Faris, Comstock, Chattoraj, Chattoraj et al., Quercetin prevents progression of disease in elastase/LPSexposed mice by negatively regulating MMP expression, Respir Res, doi:10.1186/1465-9921-11-131
Ganesan, Faris, Comstock, Wang, Nanua et al., Quercetin inhibits rhinovirus replication in vitro and in vivo, Antiviral Res, doi:10.1016/j.antiviral.2012.03.005
Gonzalez, Berdiel, Duconge, Levy, Alfaro et al., High dose intravenous vitamin C and influenza: a case report, J Orthomol Med
Gonzalez, Fontanes, Raychaudhuri, Loo, Loo et al., The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production, Hepatology, doi:10.1002/hep.23232
Gormaz, Quintremil, Cardiovascular disease: a target for the pharmacological effects of quercetin, Curr Top Med Chem, doi:10.2174/1568026615666150427124357
Graefe, Derendorf, Veit, Pharmacokinetics and bioavailability of the flavonol quercetin in humans, Int J Clin Pharmacol Ther
Guo, Bruno, Endogenous and exogenous mediators of quercetin bioavailability, J Nutr Biochem, doi:10.1016/j.jnutbio.2014.10.008
Gábor, Szent-Györgyi and the bioflavonoids: new results and perspectives of pharmacological research into benzo-pyrone derivatives. Commemoration on the 50th anniversary of the award of the Nobel Prize, Prog Clin Biol Res
Güttner, Veckenstedt, Heinecke, Pusztai, Effect of quercetin on the course of mengo virus infection in immunodeficient and normal mice. A histologic study, Acta Virol
Hah, Chung, Sontakke, Chung, Ju, Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study, BMC Ophthalmol, doi:10.1186/s12886-017-0515-2
Harakeh, Jariwalla, Pauling, Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells, Proc Natl Acad Sci, doi:10.1073/pnas.87.18.7245
Harwood, Danielewska-Nikiel, Borzelleca, Flamm, Williams et al., A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties, Food Chem Toxicol, doi:10.1016/j.fct.2007.05.015
Horvath, The Jak-STAT pathway stimulated by interferon gamma, Sci STKE, doi:10.1126/stke.2602004tr8
Hosokawa, Hirayoshi, Kudo, Takechi, Aoike et al., Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids, Mol Cell Biol, doi:10.1128/MCB.12.8.3490
Hosokawa, Hirayoshi, Nakai, Hosokawa, Marui et al., Flavonoids inhibit the expression of heat shock proteins, Cell Struct Funct, doi:10.1247/csf.15.393
Huang, Hwang, Lee, Ke, Huang et al., Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor, Br J Pharmacol, doi:10.1038/sj.bjp.0702879
Iii, Kim, Lepler, Malhotra, Debesa et al., Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome, World J Crit Care Med, doi:10.5492/wjccm.v6.i1.85
Inal, Kahraman, The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats, Toxicology, doi:10.1016/S0300-483X(00)00268-7
Itsuka, Ohsawa, Ohiwa, Umeda, Suharay, Antipicornavirus flavone Ro 09-0179, Antimicrob Agents Chemother, doi:10.1128/AAC.22.4.611
Kataoka, Imai, Inayoshi, Tsuda, Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy, J Neurol Neurosurg Psychiatry, doi:10.1136/jnnp.56.11.1213
Kaul, Middleton, Ogra, Antiviral effect of flavonoids on human viruses, J Med Virol, doi:10.1002/jmv.1890150110
Khoo, White, Pozzo-Miller, Zhou, Inoueandparks, Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels, Free Radic Biol Med, doi:10.1016/j.freeradbiomed.2010.04.022
Kim, Kim, Bae, Choi, Lim et al., Vitamin C is an essential factor on the anti-viral immune responses through the production of interferon-α/β at the initial stage of influenza A virus (H3N2) infection, Immune Netw, doi:10.4110/in.2013.13.2.70
Kim, Kim, Na, Shin, A study of intravenous administration of vitamin c in the treatment of acute herpetic pain and postherpetic neuralgia, Ann Dermatol, doi:10.5021/ad.2016.28.6.677
Kim, Yoo, Park, Chung, Han et al., Clinical features of herpes simplex keratitis in a Korean tertiary referral center: efficacy of oral antiviral and ascorbic acid on recurrence, Kor J Ophthalmol, doi:10.3341/kjo.2017.0131
Kimbarowski, Mokrow, Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza, Das Deutsche Gesundheitswesen
Lahiri, Lloyd, The effect of stress and corticotrophin on the concentrations of vitamin C in blood and tissues of the rat, Biochem. J, doi:10.1042/bj0840478
Leibovitz, Siegel, Ascorbic acid and the immune response, Adv Exp Med Biol, doi:10.1007/978-1-4615-9200-6_1
Li, Maeda, Beck, Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/-mice, J Nutr, doi:10.1093/jn/136.10.2611
Li, Yao, Han, Yang, Chaudhry et al., Quercetin, inflammation and immunity, Nutrients, doi:10.3390/nu8030167
Li, Zhang, Serrao, Chen, Sanchez et al., Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75, Bioorg Med Chem, doi:10.1016/j.bmc.2014.04.016
Liu, Wu, Jiang, HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds, Curr Pharm Des, doi:10.2174/138161207779313722
Lu, Zhao, Li, Niu, Yang et al., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Lancet, doi:10.1016/S0140-6736(20)30251-8
Manning, Mitchell, Appadurai, Shakya, Pierce et al., Vitamin C promotes maturation of T-cells, Antioxid Redox Signal, doi:10.1089/ars.2012.4988
Marik, Hooper, Doctor-your septic patients have scurvy!, Crit Care, doi:10.1186/s13054-018-1950-z
Marik, Vitamin C for the treatment of sepsis: the scientific rationale, Pharmacol Ther, doi:10.1016/j.pharmthera.2018.04.007
Marik, Vitamin C: an essential "stress hormone" during sepsis, J Thorac Dis, doi:10.21037/jtd.2019.12.64
Marra, Jones, Astell, Holt, Brooks-Wilson et al., The genome sequence of the SARS-associated coronavirus, Science, doi:10.1126/science.1085953
Mikirova, Hunninghake, Effect of high dose vitamin C on Epstein-Barr viral infection, Med Sci Monit, doi:10.12659/MSM.890423
Moalin, Van Strijdonck, Bast, Haenen, Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin
Moon, Wang, Dicenzo, Morris, Quercetin pharmacokinetics in humans, Biopharm Drug Dispos, doi:10.1002/bdd.605
Morikawa, Nonaka, Narahara, Torii, Kawaguchi et al., Inhibitory effect of quercetin on carrageenan-induced inflammation in rats, Life Sci, doi:10.1016/j.lfs.2003.06.036
Murota, Terao, Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism, Arch Biochem Biophys, doi:10.1016/S0003-9861(03)00284-4
Nabavi, Nabavi, Eslami, Moghaddam, In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue, Food Chem, doi:10.1016/j.foodchem.2011.11.070
Nair, Kandaswami, Mahajan, Chadha, Chawda et al., The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells, Biochim Biophys Acta, doi:10.1016/S0167-4889(02)00328-2
Nakagawa, Nakahara, Maruyama, Kawabata, Higuchi et al., Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis, J Neurovirol, doi:10.3109/13550289609146899
Nanua, Zick, Andrade, Sajjan, Burgess et al., Quercetin blocks airway epithelial cell chemokine expression, Am J Respir Cell Mol Biol, doi:10.1165/rcmb.2006-0149OC
Nieman, Henson, Davis, Dumke, Gross et al., Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run, J Interferon Cytokine Res, doi:10.1089/jir.2007.0050
Nieman, Henson, Davis, Murphy, Jenkins et al., Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA, J Appl Physiol, doi:10.1152/japplphysiol.00707.2007
Nieman, Henson, Gross, Jenkins, Davis et al., Quercetin reduces illness but not immune perturbations after intensive exercise, Med Sci Sports Exerc, doi:10.1249/mss.0b013e318076b566
Ono, Nakane, Fukushima, Chermann, Barré-Sinoussi, Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases, Eur J Biochem, doi:10.1111/j.1432-1033.1990.tb15597.x
Ono, Nakane, Mechanisms of inhibition of various cellular DNA and RNA polymerases by several flavonoids, J Biochem, doi:10.1093/oxfordjournals.jbchem.a123251
Pace-Asciak, Hahn, Diamandis, Soleas, Goldberg, The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease, Clin Chim Acta, doi:10.1016/0009-8981(95)06045-1
Palma, Vliegen, Clercq, Neyts, Selective inhibitors of picornavirus replication, Med Res Rev, doi:10.1002/med.20125
Peet, Li, IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin, J Biol Chem, doi:10.1074/jbc.274.46.32655
Robaszkiewicz, Balcerczyk, Bartosz, Antioxidative and prooxidative effects of quercetin on A549 cells, Cell Biol Int, doi:10.1016/j.cellbi.2007.04.009
Rogerio, Kanashiro, Fontanari, Da Silva, Valim et al., Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma, Inflamm Res, doi:10.1007/s00011-007-7005-6
Rota, Oberste, Monroe, Nix, Campagnoli et al., Characterization of a novel coronavirus associated with severe acute respiratory syndrome, Science, doi:10.1126/science.1085952
Roubalová, Purchartová, Papoušková, Vacek, Kren et al., Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: an examination of quercetin, isoquercitrin and taxifolin, Bioorg Med Chem, doi:10.1016/j.bmc.2015.07.055
Ruotolo, Calani, Brighenti, Crozier, Ottonello et al., Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell model systems, Arch Biochem Biophys, doi:10.1016/j.abb.2014.03.003
Shen, Wang, Zhao, Yang, Li et al., Treatment of 5 critically Ill patients with COVID-19 with convalescent plasma, JAMA, doi:10.1001/jama.2020.4783
Shinozuka, Kikuchi, Nishino, Mori, Tawata, Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases, Experientia, doi:10.1007/BF01941188
Shoskes, Zeitlin, Shahed, Rajfer, Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial, Urology, doi:10.1016/S0090-4295(99)00358-1
Siegel, Enhanced interferon response to murine leukemia virus by ascorbic acid, Infect Immun, doi:10.1128/IAI.10.2.409-410.1974
Siegel, Enhancement of interferon production by poly(rI)-poly(rC) in mouse cell cultures by ascorbic acid, Nature, doi:10.1038/254531a0
Snijder, Bredenbeek, Dobbe, Thiel, Ziebuhr et al., Unique and conserved features of genome and proteome of SARScoronavirus, an early split-off from the coronavirus group 2 lineage, J Mol Biol, doi:10.1016/S0022-2836(03)00865-9
Spedding, Ratty, Middleton, Inhibition of reverse transcriptases by flavonoids, Antiviral Res, doi:10.1016/0166-3542(89)90073-9
Stantic-Pavlinic, Banic, Marin, Klemenc, Vitamin C-a challenge in management of rabies, Swiss Med Weekly
Terao, Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (-)-epicatechin and quercetin participate in antioxidative defense in blood plasma, J Med Invest
Terao, Murota, Kawai, Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo, Food Funct, doi:10.1039/C0FO00106F
Uchide, Toyoda, Antioxidant therapy as a potential approach to severe influenza-associated complications, Molecules, doi:10.3390/molecules16032032
Valero, Mosquera, Alcocer, Bonilla, Salazar et al., Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis, Brain Res, doi:10.1016/j.brainres.2015.06.034
Veckenstedt, Béládi, Mucsi, Effect of treatment with certain flavonoids on Mengo virus-induced encephalitis in mice, Arch Virol, doi:10.1007/BF01315089
Vrijsen, Everaert, Boeyé, Antiviral activity of flavones and potentiation by ascorbate, J Gen Virol, doi:10.1099/0022-1317-69-7-1749
Vrijsen, Everaert, Hoof, Vlietinck, Vanden Berghe et al., The poliovirus-induced shut-off of cellular protein synthesis persists in the presence of 3-methylquercetin, a flavonoid which blocks viral protein and RNA synthesis, Antiviral Res, doi:10.1016/0166-3542(87)90037-4
Wang, Nie, Wang, Zhao, Xiong et al., Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia, J Infect Dis, doi:10.1093/infdis/jiaa150
Winkel-Shirley, Biosynthesis, A colorful model for genetics, biochemistry, cell biology, and biotechnology, Plant Physiol, doi:10.1104/pp.126.2.485
Wu, Li, Li, He, Jiang et al., Quercetin as an antiviral agent inhibits Influenza A Virus (IAV) entry, Viruses, doi:10.3390/v8010006
Xia, Liu, Wang, Sun, Su et al., Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein, Virus Res, doi:10.1016/j.virusres.2014.10.007
Xu, Wan, Dong, But, Foo, Inhibitory activity of flavonoids and tannins against HIV-1 protease, Biol Pharm Bull, doi:10.1248/bpb.23.1072
Yang, Li, Shen, Liu, Influenza A virus entry inhibitors targeting the hemagglutinin, Viruses, doi:10.3390/v5010352
Ye, Fu, Ren, Wang, Wang et al., Treatment with convalescent plasma for COVID-19 patients in Wuhan, China, J Med Virol, doi:10.1002/jmv.25882
Yi, Li, Yuan, Qu, Chen et al., Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells, J Virol, doi:10.1128/JVI.78.20.11334-11339.2004
Zandi, Teoh, Sam, Wong, Mustafa et al., Antiviral activity of four types of bioflavonoid against dengue virus type-2, Virol J, doi:10.1186/1743-422X-8-560
Zhang, Lin, Sun, Curth, Drosten et al., Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors, Science, doi:10.3410/f.737592020.793572879
Zhou, Yang, Wang, Hu, Zhang et al., A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, doi:10.1038/s41586-020-2012-7
Zuo, Yalavarthi, Shi, Gockman, Zuo et al., Neutrophil extracellular traps in COVID-19, JCI Insight, doi:10.1172/jci.insight.138999
Áy, Hunyadi, Mezei, Minárovits, Hohmann, Flavonol 7-O-glucoside herbacitrin inhibits HIV-1 replication through simultaneous integrase and reverse transcriptase inhibition, Evid Based Complement Alternat Med, doi:10.1155/2019/1064793
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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