Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients
Meenu Bajpai, Ashish Maheshwari, Suresh Kumar, Karan Chhabra, Pratibha Kale, Ashad Narayanan, Amita Gupta, Ekta Gupta, Nirupama Trehanpati, Reshu Agarwal, Kamini Gupta, MOJAHIDUL ISLAM Ankit Bhardwaj, Mojahidul Islam, Ravinder Singh, Pushpa Yadav, Guresh Kumar, Shiv K Sarin
Anais da Academia Brasileira de Ciências, doi:10.1590/0001-3765202220210202
background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared effi cacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not signifi cant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.
Author contributions 1.Study concept and design: Shiv K Sarin, Meenu Bajpai, Ashish Maheshwari, Suresh Kumar and Ekta Gupta. 2.Acquisition of data: Karan Chhabra, Ashad Narayan, Pratibha Kale, Amita Gupta, Reshu Agarwal, Kamini Gupta, Mojahidul Islam, Ravinder Singh and Pushpa Yadav. 3. Statistical analysis: Guresh Kumar, Ankit Bhardwaj. 4.Initial Drafting of the Manuscript: Suresh Kumar, Ashish Maheshwari, Pratibha Kale, Ekta Gupta, Nirupama Trehanpati, Karan Chhabra, Ankit Bhardwaj, Ashad Narayan, Amita Gupta, Reshu Agarwal, Kamini Gupta, Mojahidul Islam, Ravinder Singh and Pushpa Yadav. 5.Critical revision of manuscript done for important intellectual content: Meenu Bajpai, Guresh Kumar and Shiv K Sarin, 6.Administrative and technical support: Shiv K Sarin.
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