ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019*
MD, MSc Sara C Auld, MD Mark Caridi-Scheible, MD James M Blum, MPH Chad Robichaux, MD, MSc Colleen Kraft, MD, MSc Jesse T Jacob, MD Craig S Jabaley, PA David Carpenter, PhD, RN Roberta Kaplow, MD, MPH Alfonso C Hernandez-Romieu, MD Max W Adelman, MD, MSc Greg S Martin, MD Craig M Coopersmith, MD, PhD David J Murphy
Critical Care Medicine, doi:10.1097/ccm.0000000000004457
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period. Interventions: None. Measurements and Main Results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associ-ated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower Pao 2 / Fio 2 ratio, higher d-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy. Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness. (Crit Care Med 2020; 48:e799-e804)
For information regarding this article, E-mail: david.j.murphy@emory.edu The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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"abstract": "<jats:sec>\n <jats:title>Objectives:</jats:title>\n <jats:p>To determine mortality rates among adults with critical illness from coronavirus disease 2019.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Design:</jats:title>\n <jats:p>Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Setting:</jats:title>\n <jats:p>Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Patients:</jats:title>\n <jats:p>Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Interventions:</jats:title>\n <jats:p>None.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Measurements and Main Results:</jats:title>\n <jats:p>Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower Pa<jats:sc>o</jats:sc>\n <jats:sub>2</jats:sub>/F<jats:sc>io</jats:sc>\n <jats:sub>2</jats:sub> ratio, higher <jats:sc>d</jats:sc>-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Conclusions:</jats:title>\n <jats:p>Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.</jats:p>\n </jats:sec>",
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