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All Studies   Meta Analysis    Recent:   

Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial

Naggie et al., JAMA, doi:10.1001/jama.2022.18590
Oct 2022  
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Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020
 
*, now with p < 0.00000000001 from 104 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19ivm.org
The ACTIV-6 trial can be found under the original release date1.
Naggie et al., 21 Oct 2022, preprint, 28 authors.
This PaperIvermectinAll
{ 'indexed': {'date-parts': [[2024, 4, 8]], 'date-time': '2024-04-08T20:34:38Z', 'timestamp': 1712608478563}, 'reference-count': 15, 'publisher': 'American Medical Association (AMA)', 'issue': '16', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 10, 25]]}, 'abstract': '<jats:sec><jats:title>Importance</jats:title><jats:p>The effectiveness of ivermectin to ' 'shorten symptom duration or prevent hospitalization among outpatients in the US with mild to ' 'moderate symptomatic COVID-19 is ' 'unknown.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate ' 'the efficacy of ivermectin, 400 μg/kg, daily for 3 days compared with placebo for the ' 'treatment of early mild to moderate ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Design, Setting, and ' 'Participants</jats:title><jats:p>ACTIV-6, an ongoing, decentralized, double-blind, ' 'randomized, placebo-controlled platform trial, was designed to evaluate repurposed therapies ' 'in outpatients with mild to moderate COVID-19. A total of 1591 participants aged 30 years and ' 'older with confirmed COVID-19, experiencing 2 or more symptoms of acute infection for 7 days ' 'or less, were enrolled from June 23, 2021, through February 4, 2022, with follow-up data ' 'through May 31, 2022, at 91 sites in the ' 'US.</jats:p></jats:sec><jats:sec><jats:title>Interventions</jats:title><jats:p>Participants ' 'were randomized to receive ivermectin, 400 μg/kg (n\u2009=\u2009817), daily for 3 days or ' 'placebo (n\u2009=\u2009774).</jats:p></jats:sec><jats:sec><jats:title>Main Outcomes and ' 'Measures</jats:title><jats:p>Time to sustained recovery, defined as at least 3 consecutive ' 'days without symptoms. There were 7 secondary outcomes, including a composite of ' 'hospitalization or death by day ' '28.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 1800 ' 'participants who were randomized (mean [SD] age, 48 [12] years; 932 women [58.6%]; 753 ' '[47.3%] reported receiving at least 2 doses of a SARS-CoV-2 vaccine), 1591 completed the ' 'trial. The hazard ratio (HR) for improvement in time to recovery was 1.07 (95% credible ' 'interval [CrI], 0.96-1.17; posterior <jats:italic>P</jats:italic> value [HR ' '&amp;amp;gt;1]\u2009=\u2009.91). The median time to recovery was 12 days (IQR, 11-13) in the ' 'ivermectin group and 13 days (IQR, 12-14) in the placebo group. There were 10 ' 'hospitalizations or deaths in the ivermectin group and 9 in the placebo group (1.2% vs 1.2%; ' 'HR, 1.1 [95% CrI, 0.4-2.6]). The most common serious adverse events were COVID-19 pneumonia ' '(ivermectin [n\u2009=\u20095]; placebo [n\u2009=\u20097]) and venous thromboembolism ' '(ivermectin [n\u2009=\u20091]; placebo [n\u2009=\u2009' '5]).</jats:p></jats:sec><jats:sec><jats:title>Conclusions and ' 'Relevance</jats:title><jats:p>Among outpatients with mild to moderate COVID-19, treatment ' 'with ivermectin, compared with placebo, did not significantly improve time to recovery. These ' 'findings do not support the use of ivermectin in patients with mild to moderate ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Trial ' 'Registration</jats:title><jats:p>ClinicalTrials.gov Identifier: <jats:ext-link ' 'xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" ' 'xlink:href="https://clinicaltrials.gov/ct2/show/NCT04885530">NCT04885530</jats:ext-link></jats:p></jats:sec>', 'DOI': '10.1001/jama.2022.18590', 'type': 'journal-article', 'created': { 'date-parts': [[2022, 10, 21]], 'date-time': '2022-10-21T18:30:36Z', 'timestamp': 1666377036000}, 'page': '1595', 'source': 'Crossref', 'is-referenced-by-count': 51, 'title': 'Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to ' 'Moderate COVID-19', 'prefix': '10.1001', 'volume': '328', 'author': [ { 'given': 'Susanna', 'family': 'Naggie', 'sequence': 'first', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}, { 'name': 'Department of Medicine, Duke University School of Medicine, ' 'Durham, North Carolina'}]}, { 'given': 'David R.', 'family': 'Boulware', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Infectious Diseases and International Medicine, ' 'University of Minnesota, Minneapolis'}]}, { 'given': 'Christopher J.', 'family': 'Lindsell', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biostatistics, Vanderbilt University Medical ' 'Center, Nashville, Tennessee'}]}, { 'given': 'Thomas G.', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biostatistics, Vanderbilt University Medical ' 'Center, Nashville, Tennessee'}]}, { 'given': 'Nina', 'family': 'Gentile', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency Medicine, Lewis Katz School of Medicine ' 'at Temple University, Philadelphia, Pennsylvania'}]}, { 'given': 'Sean', 'family': 'Collins', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biostatistics, Vanderbilt University Medical ' 'Center, Nashville, Tennessee'}]}, { 'given': 'Matthew William', 'family': 'McCarthy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Weill Cornell Medicine, New York, New ' 'York'}]}, { 'given': 'Dushyantha', 'family': 'Jayaweera', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Miller School of Medicine, University of ' 'Miami, Miami, Florida'}]}, { 'given': 'Mario', 'family': 'Castro', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Pulmonary, Critical Care and Sleep Medicine, ' 'University of Missouri-Kansas City School of Medicine, Kansas ' 'City, Kansas'}]}, { 'given': 'Mark', 'family': 'Sulkowski', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Infectious Diseases, Johns Hopkins University, ' 'Baltimore, Maryland'}]}, { 'given': 'Kathleen', 'family': 'McTigue', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, University of Pittsburgh Medical Center, ' 'Pittsburgh, Pennsylvania'}]}, { 'given': 'Florence', 'family': 'Thicklin', 'sequence': 'additional', 'affiliation': [{'name': 'Stakeholder Advisory Committee, Pittsburgh, Pennsylvania'}]}, { 'given': 'G. Michael', 'family': 'Felker', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}, { 'name': 'Department of Medicine, Duke University School of Medicine, ' 'Durham, North Carolina'}]}, { 'given': 'Adit A.', 'family': 'Ginde', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Emergency Medicine, University of Colorado ' 'Denver-Anschutz, Denver'}]}, { 'given': 'Carolyn T.', 'family': 'Bramante', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Infectious Diseases and International Medicine, ' 'University of Minnesota, Minneapolis'}]}, { 'given': 'Alex J.', 'family': 'Slandzicki', 'sequence': 'additional', 'affiliation': [{'name': 'Clinical Trials Center of Middle Tennessee, Franklin'}]}, { 'given': 'Ahab', 'family': 'Gabriel', 'sequence': 'additional', 'affiliation': [{'name': 'Focus Clinical Research Solutions, Charlotte, North Carolina'}]}, { 'given': 'Nirav S.', 'family': 'Shah', 'sequence': 'additional', 'affiliation': [{'name': 'NorthShore University HealthSystem, Evanston, Illinois'}]}, { 'given': 'Leslie A.', 'family': 'Lenert', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Medical University of South Carolina, ' 'Charleston'}]}, { 'given': 'Sarah E.', 'family': 'Dunsmore', 'sequence': 'additional', 'affiliation': [ { 'name': 'National Center for Advancing Translational Sciences, Bethesda, ' 'Maryland'}]}, { 'given': 'Stacey J.', 'family': 'Adam', 'sequence': 'additional', 'affiliation': [ { 'name': 'Foundation for the National Institutes of Health, Bethesda, ' 'Maryland'}]}, { 'given': 'Allison', 'family': 'DeLong', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}]}, { 'given': 'George', 'family': 'Hanna', 'sequence': 'additional', 'affiliation': [ { 'name': 'Biomedical Advanced Research and Development Authority, ' 'Washington, DC'}]}, { 'given': 'April', 'family': 'Remaly', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}]}, { 'given': 'Rhonda', 'family': 'Wilder', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}]}, { 'given': 'Sybil', 'family': 'Wilson', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}]}, { 'given': 'Elizabeth', 'family': 'Shenkman', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Outcomes & Biomedical Informatics, College ' 'of Medicine, University of Florida, Gainesville'}]}, { 'given': 'Adrian F.', 'family': 'Hernandez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Duke Clinical Research Institute, Duke University School of ' 'Medicine, Durham, North Carolina'}, { 'name': 'Department of Medicine, Duke University School of Medicine, ' 'Durham, North Carolina'}]}, { 'given': 'William (Kelly)', 'family': 'Vincent', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Raina', 'family': 'Vincent', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Ray', 'family': 'Bianchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Jen', 'family': 'Premas', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Diana', 'family': 'Cordero-Loperena', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Evelyn', 'family': 'Rivera', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Madhu', 'family': 'Gupta', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Greg', 'family': 'Karawan', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Carey', 'family': 'Ziomek', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Joseph', 'family': 'Arena', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Sonaly', 'family': 'DeAlmeida', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Soroush', 'family': 'Ramin', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Jaya', 'family': 'Nataraj', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Michael', 'family': 'Paasche-Orlow', 'sequence': 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COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Sebastian', 'family': 'Munoz', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'David', 'family': 'Kavtaradze', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Cassandra', 'family': 'Watson', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'David', 'family': 'Singleton', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Maria', 'family': 'Rivon', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Amanda', 'family': 'Sevier', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Arnold', 'family': 'Del Pilar', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Amber', 'family': 'Spangler', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Sohail', 'family': 'Rao', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Luis', 'family': 'Cantu', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Arvind', 'family': 'Krishna', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Kathy', 'family': 'Evans', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Tylene', 'family': 'Falkner', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Brandi', 'family': 'Kerr', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Robert', 'family': 'Spees', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Mailyn', 'family': 'Marta', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'G. Michael', 'family': 'Felker', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Amanda', 'family': 'Harrington', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Rowena', 'family': 'Dolor', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Madison', 'family': 'Frazier', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Lorraine', 'family': 'Vergara', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Jessica', 'family': 'Wilson', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Valencia', 'family': 'Burruss', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Terri', 'family': 'Hurst', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Igho', 'family': 'Ofotokun', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Laurel', 'family': 'Bristow', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Rajesh', 'family': 'Prabhu', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Krystal', 'family': 'Klicka', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Amber', 'family': 'Lightfeather', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Vicki', 'family': 'James', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Marcella', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Pradeep', 'family': 'Parihar', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': "De'Ambra", 'family': 'Torress', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Chukwuemeka', 'family': 'Oragwu', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Ngozi', 'family': 'Oguego', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Rajesh', 'family': 'Pillai', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Mustafa', 'family': 'Juma', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Ahab', 'family': 'Gabriel', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Emad', 'family': 'Ghaly', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Dafer', 'family': 'Al-Haddadin', 'sequence': 'additional', 'affiliation': [ { 'name': 'for 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'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Amber', 'family': 'Vongsamphanh', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Maria', 'family': 'Weir', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'given': 'Nicole', 'family': 'Zaleski', 'sequence': 'additional', 'affiliation': [ { 'name': 'for the Accelerating COVID-19 Therapeutic Interventions and ' 'Vaccines (ACTIV-6) Study Group and Investigators'}]}, { 'name': 'Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-6) Study Group ' 'and Investigators', 'sequence': 'additional', 'affiliation': []}], 'member': '10', 'reference': [ { 'issue': '6', 'key': 'joi220112r1', 'doi-asserted-by': 'publisher', 'first-page': '509', 'DOI': '10.1056/NEJMoa2116044', 'article-title': 'Molnupiravir for oral treatment of COVID-19 in nonhospitalized ' 'patients.', 'volume': '386', 'author': 'Jayk Bernal', 'year': '2022', 'journal-title': 'N Engl J Med'}, { 'issue': '22', 'key': 'joi220112r2', 'doi-asserted-by': 'publisher', 'first-page': '2292', 'DOI': '10.1001/jama.2020.22760', 'article-title': 'Fluvoxamine vs placebo and clinical deterioration in outpatients with ' 'symptomatic COVID-19: a randomized clinical trial.', 'volume': '324', 'author': 'Lenze', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '1', 'key': 'joi220112r3', 'doi-asserted-by': 'publisher', 'first-page': 'e42', 'DOI': '10.1016/S2214-109X(21)00448-4', 'article-title': 'Effect of early treatment with fluvoxamine on risk of emergency care ' 'and hospitalisation among patients with COVID-19: the TOGETHER ' 'randomised, platform clinical trial.', 'volume': '10', 'author': 'Reis', 'year': '2022', 'journal-title': 'Lancet Glob Health'}, { 'issue': '10303', 'key': 'joi220112r4', 'doi-asserted-by': 'publisher', 'first-page': '843', 'DOI': '10.1016/S0140-6736(21)01744-X', 'article-title': 'Inhaled budesonide for COVID-19 in people at high risk of complications ' 'in the community in the UK (PRINCIPLE): a randomised, controlled, ' 'open-label, adaptive platform trial.', 'volume': '398', 'author': 'Yu', 'year': '2021', 'journal-title': 'Lancet'}, { 'issue': '14', 'key': 'joi220112r5', 'doi-asserted-by': 'publisher', 'first-page': '1426', 'DOI': '10.1001/jama.2021.3071', 'article-title': 'Effect of ivermectin on time to resolution of symptoms among adults ' 'with mild COVID-19: a randomized clinical trial.', 'volume': '325', 'author': 'López-Medina', 'year': '2021', 'journal-title': 'JAMA'}, { 'issue': '8', 'key': 'joi220112r6', 'doi-asserted-by': 'publisher', 'first-page': '693', 'DOI': '10.1056/NEJMoa2021436', 'article-title': 'Dexamethasone in hospitalized patients with COVID-19.', 'volume': '384', 'author': 'Horby', 'year': '2021', 'journal-title': 'N Engl J Med'}, { 'issue': '4', 'key': 'joi220112r7', 'doi-asserted-by': 'publisher', 'first-page': '426', 'DOI': '10.1001/jamainternmed.2022.0189', 'article-title': 'Efficacy of ivermectin treatment on disease progression among adults ' 'with mild to moderate COVID-19 and comorbidities: the I-TECH randomized ' 'clinical trial.', 'volume': '182', 'author': 'Lim', 'year': '2022', 'journal-title': 'JAMA Intern Med'}, { 'issue': '10285', 'key': 'joi220112r8', 'doi-asserted-by': 'publisher', 'first-page': '1637', 'DOI': '10.1016/S0140-6736(21)00676-0', 'article-title': 'Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): ' 'a randomised, controlled, open-label, platform trial.', 'volume': '397', 'author': 'RECOVERY Collaborative Group', 'year': '2021', 'journal-title': 'Lancet'}, { 'key': 'joi220112r9', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2020.104787', 'article-title': 'The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 ' 'in vitro.', 'volume': '178', 'author': 'Caly', 'year': '2020', 'journal-title': 'Antiviral Res'}, { 'issue': '6', 'key': 'joi220112r10', 'doi-asserted-by': 'publisher', 'first-page': 'e286', 'DOI': '10.1016/S2589-7500(20)30086-8', 'article-title': 'A real-time dashboard of clinical trials for COVID-19.', 'volume': '2', 'author': 'Thorlund', 'year': '2020', 'journal-title': 'Lancet Digit Health'}, { 'issue': '2', 'key': 'joi220112r11', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/ofid/ofab645', 'article-title': 'Ivermectin for COVID-19: addressing potential bias and medical fraud.', 'volume': '9', 'author': 'Hill', 'year': '2022', 'journal-title': 'Open Forum Infect Dis'}, { 'issue': '2', 'key': 'joi220112r13', 'doi-asserted-by': 'publisher', 'first-page': '135', 'DOI': '10.1177/0885066620973585', 'article-title': 'Retracted article: Clinical and scientific rationale for the “MATH+” ' 'hospital treatment protocol for COVID-19.', 'volume': '36', 'author': 'Kory', 'year': '2021', 'journal-title': 'J Intensive Care Med'}, { 'issue': '18', 'key': 'joi220112r14', 'doi-asserted-by': 'publisher', 'first-page': '1721', 'DOI': '10.1056/NEJMoa2115869', 'article-title': 'Effect of early treatment with ivermectin among patients with COVID-19.', 'volume': '386', 'author': 'Reis', 'year': '2022', 'journal-title': 'N Engl J Med'}, { 'key': 'joi220112r12', 'unstructured': 'Research Square. Retraction notice: Elgazzar A. Efficacy and safety of ' 'ivermectin for treatment and prophylaxis of COVID-19 pandemic. Preprint ' 'posted July 14, 2021, withdrawn November 16, 2021. Accessed June 8, ' '2022. https://www.researchsquare.com/article/rs-100956/v4'}, { 'key': 'joi220112r15', 'unstructured': 'R Core Team. R: A language and environment for statistical computing. R ' 'Foundation for Statistical Computing. Accessed September 19, 2022. ' 'https://www.R-project.org/'}], 'container-title': 'JAMA', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://jamanetwork.com/journals/jama/articlepdf/2797483/jama_naggie_2022_oi_220112_1692105760.87877.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 8, 15]], 'date-time': '2023-08-15T15:45:11Z', 'timestamp': 1692114311000}, 'score': 1, 'resource': {'primary': {'URL': 'https://jamanetwork.com/journals/jama/fullarticle/2797483'}}, 'subtitle': ['A Randomized Clinical Trial'], 'short-title': [], 'issued': {'date-parts': [[2022, 10, 25]]}, 'references-count': 15, 'journal-issue': {'issue': '16', 'published-print': {'date-parts': [[2022, 10, 25]]}}, 'URL': 'http://dx.doi.org/10.1001/jama.2022.18590', 'relation': {}, 'ISSN': ['0098-7484'], 'subject': ['General Medicine'], 'container-title-short': 'JAMA', 'published': {'date-parts': [[2022, 10, 25]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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