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Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abaleke et al., The Lancet, doi:10.1016/S0140-6736(21)00149-5, RECOVERY, NCT04381936
Feb 2021  
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Mortality, day 28 3% primary Improvement Relative Risk Mortality 3% Ventilation 8% Time to discharge 9% no CI Azithromycin  RECOVERY  LATE TREATMENT  RCT Is late treatment with azithromycin beneficial for COVID-19? RCT 7,763 patients in the United Kingdom (April - November 2020) No significant difference in outcomes seen c19early.org Abaleke et al., The Lancet, February 2021 Favorsazithromycin Favorscontrol 0 0.5 1 1.5 2+
RCT 7,763 hospitalized COVID-19 patients showing no significant differences with very late (75% on oxygen at baseline) azithromycin treatment. Only 91% of treatment patients received azithromycin and 17% of control patients received azithromycin or other macrolides.
risk of death, 3.0% lower, RR 0.97, p = 0.50, treatment 561 of 2,430 (23.1%), control 1,162 of 4,881 (23.8%), NNT 139, day 28, primary outcome.
risk of death, 3.0% lower, RR 0.97, p = 0.52, treatment 496 of 2,430 (20.4%), control 1,028 of 4,881 (21.1%), NNT 154.
risk of mechanical ventilation, 8.0% lower, RR 0.92, p = 0.29, treatment 211 of 2,430 (8.7%), control 461 of 4,881 (9.4%), NNT 131.
time to discharge, 9.1% lower, relative time 0.91, treatment 2,582, control 5,181.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abaleke et al., 28 Feb 2021, Randomized Controlled Trial, United Kingdom, peer-reviewed, mean age 65.0, 5370 authors, study period 7 April, 2020 - 27 November, 2020, average treatment delay 8.0 days, trial NCT04381936 (history) (RECOVERY). Contact: recoverytrial@ndph.ox.ac.uk.
This PaperMiscellaneousAll
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Eugenia Abaleke, Mustafa Abbas, Sadia Abbasi, Alfie Abbott, Ashraf Abdelaziz, Sherif Abdelbadiee, Mohamed Abdelfattah, Basir Abdul, Althaf Abdul Rasheed, Rezan Abdul-Kadir, Abdulfatahi Abdulmumeen, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ua Abeer Ul Amna, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Devikumar Acharya, Janet Acheson, Andres Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Kate Adams, Richard Adams, Tim Adams, Malgorzata Adamus, Kirsty Adcock, Aderonke Adebiyi, Ken Adegoke, Vicki Adell, Aldrin Adeni, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Elizabeth Adeyeye, Gabrielle Adkins, Adnan Adnan, John Aeron-Thomas, Lynn Afari, Debbie Affleck, Carmel Afnan, Deborah Afolabi, Muhammad Afridi, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, Judith Agwada-Akeru, Kwame A Agyapong, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Jonathan Ah-Chuen, Mahin Ahmad, Ashar Ahmed, Bilal Ahmed, Forizuddin Ahmed, Iram Ahmed, Irshad Ahmed, Liban Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Syed H Ahmed, Roa Ahmed Ali, Sana Ahmer, Dhiraj Ail, Adam Ainsley, Mark Ainsworth, Myriam Aissa, Lucy Aitchson, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Muhammad N Akhtar, Nasim Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Umeh Akudo, Asma Al Balushi, Majd Al Dakhola, Narendra Aladangady, Sajid Alam, Abbas Al-Asadi, Kyriaki Alatzoglou, Lorraine Albon, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John Alexander, Peter Dg Alexander, Julyan Al-Fori, Bahij Al-Hakim, Shams Al-Hity, Ali Ali, Anyat Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Oudai Ali, Sakina Ali, Syed Ali, Abid Alina, Katrin Alizaedeh, Maithem Al-Jibury, Moutaz Alkhusheh, Alison Allanson, Robert Allcock, Eireann Allen, Jonathan Allen, Kerry Allen, Louise Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Christine Almadenboyle, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Warkaq Al-Shamkhani, Bashar Al-Sheklly, Mary Alvarez, Maysaa Alzetani, Susan Amamou, Sakarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Maria R Amezaga, Allison Amin, Amina Amin, Kanish Amin, Amjad Amjad, Victoria Amosun, Khaled Amsha, Atul Anand, Samantha Anandappa, Julie Anderson, Laura Anderson, Michelle Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Prematie Andreou, Angela Andrews, Jill Andrews, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Varghese Anu, Muhammad Anwar, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Bianca Araba, Angela Aramburo, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Dhawal Arora, Pardeep Arora, Rishi Arora, Arslam Arter, Ganesh Arunachalam, Rita Arya, Salma Asam, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Helen Ashby, Jan Ashcroft, John Ashcroft, Ayesha Ashfaq, Abdul Ashish, Sally Ashman-Flavell, Sundar Ashok, Muhammad Z Ashraf, Saima Ashraf, Mohammad B Ashraq, Deborah Ashton, Susan Ashton, Andrew Ashworth, Rebecca Ashworth, Harshini Asogan
The Lancet, doi:10.1016/s0140-6736(21)00149-5
Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19. Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospital with COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once per day by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatment groups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment and were twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants and local study staff were not masked to the allocated treatment, but all others involved in the trial were masked to the outcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) were eligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was 65•3 years (SD 15•7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomly allocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall, 561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days (rate ratio 0•97, 95% CI 0•87-1•07; p=0•50). No significant difference was seen in duration of hospital stay (median 10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 1•04, 95% CI 0•98-1•10; p=0•19). Among those not on invasive mechanical ventilation at baseline, no significant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilation or death (risk ratio 0•95, 95% CI 0•87-1•03; p=0•24). Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restricted to patients in whom there is a clear antimicrobial indication.
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{'given': 'Helen', 'family': 'Cheshire', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Chessell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chee Kay', 'family': 'Cheung', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elaine', 'family': 'Cheung', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'Cheyne', 'sequence': 'additional', 'affiliation': []}, {'given': 'Swati', 'family': 'Chhabra', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eric', 'family': 'Chiang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Angela', 'family': 'Chiapparino', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rosavic', 'family': 'Chicano', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sam', 'family': 'Chilcott', 'sequence': 'additional', 'affiliation': []}, {'given': 'Phillipa', 'family': 'Chimbo', 'sequence': 'additional', 'affiliation': []}, {'given': 'KokWai', 'family': 'Chin', 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{'given': 'Jennifer', 'family': 'Crooks', 'sequence': 'additional', 'affiliation': []}, {'given': 'Harriet', 'family': 'Crosby', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tim', 'family': 'Cross', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephen', 'family': 'Crotty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susan', 'family': 'Crouch', 'sequence': 'additional', 'affiliation': []}, {'given': 'Madeleine', 'family': 'Crow', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rory', 'family': 'Crowder', 'sequence': 'additional', 'affiliation': []}, {'given': 'Becky', 'family': 'Crowe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rebecca', 'family': 'Croysdill', 'sequence': 'additional', 'affiliation': []}, {'given': 'Irena', 'family': 'Cruickshank', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Cruise', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carina', 'family': 'Cruz', 'sequence': 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{'given': 'Melanie', 'family': 'Harrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rowan', 'family': 'Harrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susie', 'family': 'Harrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tom', 'family': 'Harrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wendy', 'family': 'Harrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elizabeth', 'family': 'Harrod', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ciaran', 'family': 'Hart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dominic', 'family': 'Hart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rosemary', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tom', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'William', 'family': 'Hartrey', 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{'given': 'Jose', 'family': 'Morales', 'sequence': 'additional', 'affiliation': []}, {'given': 'Edward', 'family': 'Moran', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louise', 'family': 'Moran', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard', 'family': 'Mordi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jeronimo', 'family': 'Moreno-Cuesta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christine', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Colin', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lauren', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Leila', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Patrick', 'family': 'Morgan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katie', 'family': 'Morgan-Jones', 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{'given': 'Niall', 'family': 'Morris', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Morris', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sheila', 'family': 'Morris', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susan', 'family': 'Morris', 'sequence': 'additional', 'affiliation': []}, {'given': 'Douglas', 'family': 'Morrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Morrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Moira', 'family': 'Morrison', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mary', 'family': 'Morrissey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna', 'family': 'Morrow', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gordon', 'family': 'Mortem', 'sequence': 'additional', 'affiliation': []}, {'given': 'Valerie', 'family': 'Mortland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chelsea', 'family': 'Morton', 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{'given': 'Borja', 'family': 'Moya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eunice', 'family': 'Mshengu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sheila', 'family': 'Mtuwa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ali', 'family': 'Muazzam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Iqtedar A', 'family': 'Muazzam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dalia', 'family': 'Mudawi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Girish', 'family': 'Muddegowda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ahsan', 'family': 'Mughal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Javaid', 'family': 'Muglu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Javed', 'family': 'Muhammad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carol', 'family': 'Muir', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sabih', 'family': 'Mukhtar', 'sequence': 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{'given': 'Andrew', 'family': 'Mumford', 'sequence': 'additional', 'affiliation': []}, {'given': 'Henry', 'family': 'Munby', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hannah', 'family': 'Munday', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne-Marie', 'family': 'Munro', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sheila', 'family': 'Munt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Arshid', 'family': 'Murad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Koteshwara', 'family': 'Muralidhara', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mhairi', 'family': 'Murdoch', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Murira', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Murphy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carl', 'family': 'Murphy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gail', 'family': 'Murphy', 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'family': 'Pessoa-Amorim', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Petch', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lionel', 'family': 'Peter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cecilia', 'family': 'Peters', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'Peters', 'sequence': 'additional', 'affiliation': []}, {'given': 'Steve', 'family': 'Peters', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tim', 'family': 'Peters', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandra', 'family': 'Peterson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Leon', 'family': 'Peto', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ilianna', 'family': 'Petrou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Boyanka', 'family': 'Petrova', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mirela', 'family': 'Petrova', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Pfeffer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mysore', 'family': 'Phanish', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Phelan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christopher', 'family': 'Philbey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Philbin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alex', 'family': 'Phillips', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dylan', 'family': 'Phillips', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rachael', 'family': 'Phillips', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marie', 'family': 'Phipps', 'sequence': 'additional', 'affiliation': []}, {'given': 'Virach', 'family': 'Phongsathorn', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nang T', 'family': 'Phoo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mandeep', 'family': 'Phull', 'sequence': 'additional', 'affiliation': []}, {'given': 'Masroor M', 'family': 'Phulpoto', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara', 'family': 'Pick', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Pickard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charlotte', 'family': 'Pickering', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gillian', 'family': 'Pickering', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Pickett', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanna', 'family': 'Pickles', 'sequence': 'additional', 'affiliation': []}, {'given': 'Benjamin', 'family': 'Pickwell-Smith', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natalia', 'family': 'Pieniazek', 'sequence': 'additional', 'affiliation': []}, {'given': 'Angelo', 'family': 'Pieris', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samia', 'family': 'Pilgrim', 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{'given': 'Aiden J', 'family': 'Plant', 'sequence': 'additional', 'affiliation': []}, {'given': 'Naomi', 'family': 'Platt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Robert', 'family': 'Pleass', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Plummer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charles', 'family': 'Plumptre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tatiana', 'family': 'Pogreban', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joshua', 'family': 'Pointon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephen', 'family': 'Poku', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rachel', 'family': 'Pollard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louisa', 'family': 'Pollock', 'sequence': 'additional', 'affiliation': []}, {'given': 'Oluwamayowa', 'family': 'Poluyi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gary J', 'family': 'Polwarth', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fiona', 'family': 'Pomery', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ponmurugan', 'family': 'Ponnusamy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aravind', 'family': 'Ponnuswamy', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Inês', 'family': 'Ponte Bettencourt dos Reis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lynda', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michele', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Poon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tajinder', 'family': 'Poonian', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Porter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Linda', 'family': 'Porter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kelly', 'family': 'Postlethwaite', 'sequence': 'additional', 'affiliation': []}, {'given': 'Narayana', 'family': 'Pothina', 'sequence': 'additional', 'affiliation': []}, {'given': 'Priyadarshan', 'family': 'Potla', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dorota', 'family': 'Potoczna', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jason', 'family': 'Pott', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Potter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean', 'family': 'Potter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Potter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elspeth', 'family': 'Potton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julie', 'family': 'Potts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kathryn', 'family': 'Potts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria', 'family': 'Poulaka', 'sequence': 'additional', 'affiliation': []}, {'given': 'Una', 'family': 'Poultney', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katherine', 'family': 'Poulton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vanessa', 'family': 'Poustie', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Powell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jordan', 'family': 'Powell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deborah', 'family': 'Power', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nick', 'family': 'Power', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joseph', 'family': 'Poxon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Robin', 'family': 'Poyner', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helena', 'family': 'Prady', 'sequence': 'additional', 'affiliation': []}, {'given': 'Krishna', 'family': 'Prasad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fredy', 'family': 'Prasanth Raj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sangeetha', 'family': 'Prasath', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anezka', 'family': 'Pratley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Euan', 'family': 'Pratt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Steven', 'family': 'Pratt', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Preiss', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'Prendergast', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lynn', 'family': 'Prentice', 'sequence': 'additional', 'affiliation': []}, {'given': 'Verity', 'family': 'Prescott', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Presland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Catharine', 'family': 'Prest', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephen', 'family': 'Preston', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natalie', 'family': 'Prevatt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sandra', 'family': 'Prew', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ashley', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carly', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elizabeth', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nathan', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vivien', 'family': 'Price', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne', 'family': 'Priest', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kate', 'family': 'Priestley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorraine', 'family': 'Primrose', 'sequence': 'additional', 'affiliation': []}, {'given': 'Judith', 'family': 'Prince', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Prince', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shirley', 'family': 'Pringle', 'sequence': 'additional', 'affiliation': []}, {'given': 'Veronika', 'family': 'Pristopan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kelly', 'family': 'Pritchard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lucy', 'family': 'Pritchard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simon', 'family': 'Pritchard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Verma', 'family': 'Priyash', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'Procter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clare', 'family': 'Proctor', 'sequence': 'additional', 'affiliation': []}, {'given': 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'affiliation': []}, { 'given': 'Saleel', 'family': 'Punnilath Abdulsamad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Purandare', 'sequence': 'additional', 'affiliation': []}, {'given': 'Martha', 'family': 'Purcell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Corrina', 'family': 'Purdue', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bally', 'family': 'Purewal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Molly', 'family': 'Pursell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gregory', 'family': 'Purssord', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Purvis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kathryn', 'family': 'Puxty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michael', 'family': 'Pynn', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tariq', 'family': 'Qadeer', 'sequence': 'additional', 'affiliation': []}, {'given': 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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