analysis of ivermectin from 11 different sources showing highly variable antiparasitic efficacy. Multiple sources and brands were more effective than the US mass produced Edenbridge brand.
Ivermectin is an inhibitor of importin-α/β-dependent nuclear
import of viral proteins
Götz, Kosyna, Wagstaff, Wagstaff (B),
a SARS-CoV-2 3CL
pro inhibitor
Mody,
binds to glycan sites on the SARS-CoV-2 spike protein preventing interaction
with blood and epithelial cells and inhibiting hemagglutination
Boschi,
exhibits dose-dependent inhibition of lung injury
Abd-Elmawla, Ma,
may inhibit SARS-CoV-2 induced formation of fibrin clots resistant to
degradation
Vottero,
shows protection against inflammation, cytokine storm, and mortality in an LPS
mouse model of severe infection/inflammation that shares key pathological
features of severe COVID-19
DiNicolantonio, Zhang,
may be beneficial in severe COVID-19 by binding IGF1 to inhibit the promotion
of inflammation, fibrosis, and cell proliferation that leads to lung damage
Zhao,
may minimize SARS-CoV-2 induced cardiac damage
Liu, Liu (B),
increases Bifidobacterium which plays a key role in the immune system
Hazan,
has immunomodulatory
Munson and anti-inflammatory
DiNicolantonio (B), Yan properties, and has an extensive and very
positive safety profile
Descotes.
