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Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis

Szente Fonseca et al., Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101906
Oct 2020  
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Hospitalization -14% primary Improvement Relative Risk Ivermectin  Szente Fonseca et al.  EARLY TREATMENT Is early treatment with ivermectin beneficial for COVID-19? Retrospective 717 patients in Brazil No significant difference in hospitalization c19ivm.org Szente Fonseca et al., Travel Medicine.., Oct 2020 Favorsivermectin Favorscontrol 0 0.5 1 1.5 2+
Ivermectin for COVID-19
4th treatment shown to reduce risk in August 2020, now with p < 0.00000000001 from 105 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19ivm.org
Retrospective 717 patients in Brazil showing OR 1.17 [0.72-1.90] for ivermectin. This paper focuses on HCQ, event counts for ivermectin are not provided. With significant correlation between the variables used, including overlap in the prescription of multiple treatments that show efficacy alone, and limited data for the model size, the model used here may be inaccurate due to multicollinearity1.
This is the 15th of 105 COVID-19 controlled studies for ivermectin, which collectively show efficacy with p<0.0000000001 (1 in 774 quintillion).
52 studies are RCTs, which show efficacy with p=0.00000021.
This study is excluded in the after exclusion results of meta analysis: result is likely affected by collinearity across treatments in the model.
Study covers ivermectin and HCQ.
risk of hospitalization, 13.9% higher, RR 1.14, p = 0.53, treatment 340, control 377, adjusted per study, odds ratio converted to relative risk, control prevalence approximated with overall prevalence, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Szente Fonseca et al., 31 Oct 2020, retrospective, Brazil, peer-reviewed, mean age 50.6, 10 authors, average treatment delay 4.6 days, dosage 12mg days 1-2.
This PaperIvermectinAll
Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis
Silvia Nunes Szente Fonseca, Anastasio De Queiroz Sousa, Alexandre Giandoni Wolkoff, Marcelo Sampaio Moreira, Bruno Castro Pinto, Christianne Fernandes Valente Takeda, Eduardo Rebouças, Ana Paula Vasconcellos Abdon, Anderson L A Nascimento, Harvey A Risch
Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101906
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflict of Interest Policy Declarations Travel Medicine and Infectious Disease requires that all authors sign a declaration of conflicting interests. If you have nothing to declare in any of these categories then this should be stated. Conflict of Interest A conflicting interest exists when professional judgement concerning a primary interest (such as patient's welfare or the validity of research) may be influenced by a secondary interest (such as financial gain or personal rivalry). It may arise for the authors when they have financial interest that may influence their interpretation of their results or those of others. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. Please state any competing interests Funding Source All sources of funding should also be acknowledged and you should declare any involvement of study sponsors in the study design; collection, analysis and interpretation of data; the writing of the manuscript; the decision to submit the manuscript for publication. If the study sponsors had no such involvement, this should be stated. Please state any sources of funding for your research Conflict of Interest A conflicting interest exists when professional judgement concerning a primary interest (such as patient's welfare or the validity of research) may be influenced by a secondary interest (such as financial..
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