Risk of hospitalization for Covid-19 outpatients treated with various drug regimens in Brazil: Comparative analysis
Silvia Nunes Szente Fonseca, Anastasio De Queiroz Sousa, Alexandre Giandoni Wolkoff, Marcelo Sampaio Moreira, Bruno Castro Pinto, Christianne Fernandes Valente Takeda, Eduardo Rebouças, Ana Paula Vasconcellos Abdon, Anderson L A Nascimento, Harvey A Risch
Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101906
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References
Baden, Rubin, Covid-19 -The search for effective therapy, N Engl J Med
Barbosa Esper, Da Silva, Costa Oikawa, Castro, Razuk-Filho et al., Empirical treatment with hydroxychloroquine and azithromycin for suspected cases of COVID-19 followed-up by telemedicine
Barnett-Howell, Mobarak, The Benefits and Costs of Social Distancing in Rich and Poor Countries
Bialek, Boundy, Bowen, Chow, Cohn et al., Severe outcomes among patients with coronavirus disease 2019 (COVID-19) -United States, February 12, MMWR Morb Mortal Wkly Rep
Brasil, Ministério da Saúde
Brasil, Nota Informativa N o 5/2020-DAF/SCTIE/MS. NOTA INFORMATIVA
Brasil, Perfil Epidemiologico Dos Pacientes Hospitalizados por Sindrome Respiratória Aguda Grave (SRAG)
Cdc, Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease
Durcan, Petri, Immunomodulators in SLE: Clinical evidence and immunologic actions, J Autoimmun
Gautret, Lagier, Parola, Hoang, Meddeb et al., Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, Int J Antimicrob Agents,
doi:10.1016/j.ijantimicag.2020.105949Ge, Wang, Yuan, Xiao, Wang et al., The epidemiology and clinical information about COVID-19, Eur J Clin Microbiol Infect Dis
Grein, Ohmagari, Shin, Diaz, Asperges et al., Compassionate Use of Remdesivir for Patients with Severe Covid-19, N Engl J Med
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Engl J Med
Ip, Ahn, Zhou, Goy, Hansen et al., Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study, Preprints,
doi:10.1101/2020.08.20.20178772J O U R N A L P R E, -p r o o f
Kolilekas, Loverdos, Giannakaki, Vlassi, Levounets et al., Can steroids reverse the severe COVID-19 induced 'cytokine storm'?, J Med Virol,
doi:10.1002/jmv.26165Kucirka, Lauer, Laeyendecker, Boon, Lessler, Variation in False Negative Rate of RT-PCR Based SARS-CoV-2 Tests by Time Since Exposure, Ann Int Med,
doi:10.7326/M20-1495Lagier, Million, Gautret, Colson, Cortaredona et al., Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis, Travel Med Infect Dis
Ly, Zanini, Laforge, Arlotto, Gentile et al., Pattern of SARS-CoV-2 infection among dependant elderly residents living in retirement homes in Marseille, France, Preprints
Nicola, Alsafi, Sohrabi, Kerwan, Al-Jabir et al., The socioeconomic implications of the coronavirus pandemic (COVID-19): A review, Int J Surg
Park, Decloedt, Rayner, Cotton, Mills, Clinical trials of disease stages in COVID 19: complicated and often misinterpreted, Lancet Glob Health,
doi:10.1016/S2214-109X(20)30365-XRentsch, Devito, Mackenna, Morton, Bhaskaran et al., Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study, Preprints,
doi:10.1101/2020.09.04.20187781Risch, Early Outpatient Treatment of Symptomatic, High-Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis, Am J Epidemiol,
doi:10.1093/aje/kwaa093JournalPre-proofSanders, Monogue, Jodlowski, Cutrell, Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review, JAMA
Siddiqi, Mehra, COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal, J Heart Lung Transplant
Wang, Cao, Zhang, Yang, Liu et al., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res
Who, Who, /Europe | Coronavirus disease (COVID-19) outbreak -WHO announces COVID-19 outbreak a pandemic
Wu, Chen, Cai, Xia, Zhou et al., Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China, JAMA Intern Med,
doi:10.1001/jamainternmed.2020.0994Wu, Mcgoogan, Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention, JAMA
Yao, Ye, Zhang, Cui, Huang et al., In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Clin Infect Dis,
doi:10.1093/cid/ciaa237DOI record:
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